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Prediction of 5-year survival in advanced-stage ovarian cancer patients based on computed tomography peritoneal carcinomatosis index

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Prediction of 5-year survival in advanced-stage ovarian cancer patients based on computed tomography peritoneal carcinomatosis index. / Diaz-Gil, Daniel; Fintelmann, Florian J; Molaei, Sanaz; Elmi, Azadeh; Hedgire, Sandeep S; Harisinghani, Mukesh G.

in: ABDOM RADIOL, Jahrgang 41, Nr. 11, 11.2016, S. 2196-2202.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Diaz-Gil, D, Fintelmann, FJ, Molaei, S, Elmi, A, Hedgire, SS & Harisinghani, MG 2016, 'Prediction of 5-year survival in advanced-stage ovarian cancer patients based on computed tomography peritoneal carcinomatosis index', ABDOM RADIOL, Jg. 41, Nr. 11, S. 2196-2202. https://doi.org/10.1007/s00261-016-0817-5

APA

Diaz-Gil, D., Fintelmann, F. J., Molaei, S., Elmi, A., Hedgire, S. S., & Harisinghani, M. G. (2016). Prediction of 5-year survival in advanced-stage ovarian cancer patients based on computed tomography peritoneal carcinomatosis index. ABDOM RADIOL, 41(11), 2196-2202. https://doi.org/10.1007/s00261-016-0817-5

Vancouver

Diaz-Gil D, Fintelmann FJ, Molaei S, Elmi A, Hedgire SS, Harisinghani MG. Prediction of 5-year survival in advanced-stage ovarian cancer patients based on computed tomography peritoneal carcinomatosis index. ABDOM RADIOL. 2016 Nov;41(11):2196-2202. https://doi.org/10.1007/s00261-016-0817-5

Bibtex

@article{94f53a356c9c4966bb45725e6a499535,
title = "Prediction of 5-year survival in advanced-stage ovarian cancer patients based on computed tomography peritoneal carcinomatosis index",
abstract = "OBJECTIVE: To evaluate whether the quantification of peritoneal metastases in advanced-stage ovarian cancer patients using the peritoneal carcinomatosis index, detected by CT (CT-PCI), correlates with the serum levels of tumor marker CA-125 and 5-year survival.METHODS: The CT-PCI was determined in 82 patients with stage III or stage IV ovarian cancer using the Sugarbaker classification prior to cytoreductive surgery. Linear regression analysis was used to correlate CT-PCI and CA-125 levels. Correlation of presurgical CT-PCI, optimal surgical cytoreduction, and 5-year survival was established using binary logistic regression analysis. A score for prediction of 5-year survival probability was established using multivariate backwards binary logistic regression.RESULTS: Presurgical CT-PCI correlates significantly with presurgical CA-125 serum levels (r = 0.487, P < 0.001). Multivariate binary logistic regression suggested significantly improved 5-year survival with lower CT-PCI and lower ECOG performance scores.CONCLUSION: CT-PCI allows quantification of peritoneal disease in advanced-stage ovarian cancer patients, similar to CA-125. CT-PCI in combination with ECOG performance has the potential to help evaluate the 5-year survival probability.",
keywords = "Aged, Biomarkers, Tumor/blood, CA-125 Antigen/blood, Contrast Media, Cytoreduction Surgical Procedures, Female, Humans, Iopamidol/analogs & derivatives, Middle Aged, Neoplasm Staging, Ovarian Neoplasms/diagnostic imaging, Peritoneal Neoplasms/diagnostic imaging, Prognosis, Survival Rate, Tomography, X-Ray Computed/methods",
author = "Daniel Diaz-Gil and Fintelmann, {Florian J} and Sanaz Molaei and Azadeh Elmi and Hedgire, {Sandeep S} and Harisinghani, {Mukesh G}",
year = "2016",
month = nov,
doi = "10.1007/s00261-016-0817-5",
language = "English",
volume = "41",
pages = "2196--2202",
journal = "ABDOM RADIOL",
issn = "2366-004X",
publisher = "Springer New York",
number = "11",

}

RIS

TY - JOUR

T1 - Prediction of 5-year survival in advanced-stage ovarian cancer patients based on computed tomography peritoneal carcinomatosis index

AU - Diaz-Gil, Daniel

AU - Fintelmann, Florian J

AU - Molaei, Sanaz

AU - Elmi, Azadeh

AU - Hedgire, Sandeep S

AU - Harisinghani, Mukesh G

PY - 2016/11

Y1 - 2016/11

N2 - OBJECTIVE: To evaluate whether the quantification of peritoneal metastases in advanced-stage ovarian cancer patients using the peritoneal carcinomatosis index, detected by CT (CT-PCI), correlates with the serum levels of tumor marker CA-125 and 5-year survival.METHODS: The CT-PCI was determined in 82 patients with stage III or stage IV ovarian cancer using the Sugarbaker classification prior to cytoreductive surgery. Linear regression analysis was used to correlate CT-PCI and CA-125 levels. Correlation of presurgical CT-PCI, optimal surgical cytoreduction, and 5-year survival was established using binary logistic regression analysis. A score for prediction of 5-year survival probability was established using multivariate backwards binary logistic regression.RESULTS: Presurgical CT-PCI correlates significantly with presurgical CA-125 serum levels (r = 0.487, P < 0.001). Multivariate binary logistic regression suggested significantly improved 5-year survival with lower CT-PCI and lower ECOG performance scores.CONCLUSION: CT-PCI allows quantification of peritoneal disease in advanced-stage ovarian cancer patients, similar to CA-125. CT-PCI in combination with ECOG performance has the potential to help evaluate the 5-year survival probability.

AB - OBJECTIVE: To evaluate whether the quantification of peritoneal metastases in advanced-stage ovarian cancer patients using the peritoneal carcinomatosis index, detected by CT (CT-PCI), correlates with the serum levels of tumor marker CA-125 and 5-year survival.METHODS: The CT-PCI was determined in 82 patients with stage III or stage IV ovarian cancer using the Sugarbaker classification prior to cytoreductive surgery. Linear regression analysis was used to correlate CT-PCI and CA-125 levels. Correlation of presurgical CT-PCI, optimal surgical cytoreduction, and 5-year survival was established using binary logistic regression analysis. A score for prediction of 5-year survival probability was established using multivariate backwards binary logistic regression.RESULTS: Presurgical CT-PCI correlates significantly with presurgical CA-125 serum levels (r = 0.487, P < 0.001). Multivariate binary logistic regression suggested significantly improved 5-year survival with lower CT-PCI and lower ECOG performance scores.CONCLUSION: CT-PCI allows quantification of peritoneal disease in advanced-stage ovarian cancer patients, similar to CA-125. CT-PCI in combination with ECOG performance has the potential to help evaluate the 5-year survival probability.

KW - Aged

KW - Biomarkers, Tumor/blood

KW - CA-125 Antigen/blood

KW - Contrast Media

KW - Cytoreduction Surgical Procedures

KW - Female

KW - Humans

KW - Iopamidol/analogs & derivatives

KW - Middle Aged

KW - Neoplasm Staging

KW - Ovarian Neoplasms/diagnostic imaging

KW - Peritoneal Neoplasms/diagnostic imaging

KW - Prognosis

KW - Survival Rate

KW - Tomography, X-Ray Computed/methods

U2 - 10.1007/s00261-016-0817-5

DO - 10.1007/s00261-016-0817-5

M3 - SCORING: Journal article

C2 - 27338731

VL - 41

SP - 2196

EP - 2202

JO - ABDOM RADIOL

JF - ABDOM RADIOL

SN - 2366-004X

IS - 11

ER -