Prediction of 5-year survival in advanced-stage ovarian cancer patients based on computed tomography peritoneal carcinomatosis index
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Prediction of 5-year survival in advanced-stage ovarian cancer patients based on computed tomography peritoneal carcinomatosis index. / Diaz-Gil, Daniel; Fintelmann, Florian J; Molaei, Sanaz; Elmi, Azadeh; Hedgire, Sandeep S; Harisinghani, Mukesh G.
In: ABDOM RADIOL, Vol. 41, No. 11, 11.2016, p. 2196-2202.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Prediction of 5-year survival in advanced-stage ovarian cancer patients based on computed tomography peritoneal carcinomatosis index
AU - Diaz-Gil, Daniel
AU - Fintelmann, Florian J
AU - Molaei, Sanaz
AU - Elmi, Azadeh
AU - Hedgire, Sandeep S
AU - Harisinghani, Mukesh G
PY - 2016/11
Y1 - 2016/11
N2 - OBJECTIVE: To evaluate whether the quantification of peritoneal metastases in advanced-stage ovarian cancer patients using the peritoneal carcinomatosis index, detected by CT (CT-PCI), correlates with the serum levels of tumor marker CA-125 and 5-year survival.METHODS: The CT-PCI was determined in 82 patients with stage III or stage IV ovarian cancer using the Sugarbaker classification prior to cytoreductive surgery. Linear regression analysis was used to correlate CT-PCI and CA-125 levels. Correlation of presurgical CT-PCI, optimal surgical cytoreduction, and 5-year survival was established using binary logistic regression analysis. A score for prediction of 5-year survival probability was established using multivariate backwards binary logistic regression.RESULTS: Presurgical CT-PCI correlates significantly with presurgical CA-125 serum levels (r = 0.487, P < 0.001). Multivariate binary logistic regression suggested significantly improved 5-year survival with lower CT-PCI and lower ECOG performance scores.CONCLUSION: CT-PCI allows quantification of peritoneal disease in advanced-stage ovarian cancer patients, similar to CA-125. CT-PCI in combination with ECOG performance has the potential to help evaluate the 5-year survival probability.
AB - OBJECTIVE: To evaluate whether the quantification of peritoneal metastases in advanced-stage ovarian cancer patients using the peritoneal carcinomatosis index, detected by CT (CT-PCI), correlates with the serum levels of tumor marker CA-125 and 5-year survival.METHODS: The CT-PCI was determined in 82 patients with stage III or stage IV ovarian cancer using the Sugarbaker classification prior to cytoreductive surgery. Linear regression analysis was used to correlate CT-PCI and CA-125 levels. Correlation of presurgical CT-PCI, optimal surgical cytoreduction, and 5-year survival was established using binary logistic regression analysis. A score for prediction of 5-year survival probability was established using multivariate backwards binary logistic regression.RESULTS: Presurgical CT-PCI correlates significantly with presurgical CA-125 serum levels (r = 0.487, P < 0.001). Multivariate binary logistic regression suggested significantly improved 5-year survival with lower CT-PCI and lower ECOG performance scores.CONCLUSION: CT-PCI allows quantification of peritoneal disease in advanced-stage ovarian cancer patients, similar to CA-125. CT-PCI in combination with ECOG performance has the potential to help evaluate the 5-year survival probability.
KW - Aged
KW - Biomarkers, Tumor/blood
KW - CA-125 Antigen/blood
KW - Contrast Media
KW - Cytoreduction Surgical Procedures
KW - Female
KW - Humans
KW - Iopamidol/analogs & derivatives
KW - Middle Aged
KW - Neoplasm Staging
KW - Ovarian Neoplasms/diagnostic imaging
KW - Peritoneal Neoplasms/diagnostic imaging
KW - Prognosis
KW - Survival Rate
KW - Tomography, X-Ray Computed/methods
U2 - 10.1007/s00261-016-0817-5
DO - 10.1007/s00261-016-0817-5
M3 - SCORING: Journal article
C2 - 27338731
VL - 41
SP - 2196
EP - 2202
JO - ABDOM RADIOL
JF - ABDOM RADIOL
SN - 2366-004X
IS - 11
ER -