Placeboeffekte in der Akutschmerztherapie
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Placeboeffekte in der Akutschmerztherapie. / Haaga, Roland; Schnabel, Alexander.
in: ANASTH INTENSIV NOTF, Jahrgang 53, Nr. 9, 09.2018, S. 579-590.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Placeboeffekte in der Akutschmerztherapie
AU - Haaga, Roland
AU - Schnabel, Alexander
N1 - CME-Fortbildung
PY - 2018/9
Y1 - 2018/9
N2 - Placebo and nocebo effects are currently within the focus of clinical and experimental pain research. Neurophysiological and psychophysiological mechanisms might play an important role. Placebo and nocebo effects might be mediated through the descendent inhibitory pain pathway via endogenous opioids. Apart from that three different psychological mechanisms might be relevant for placebo and nocebo effects: classical conditioning, social learning and pain expectation. An open analgesic drug application, detailed patient information about efficacy and possible adverse events (without an extensive focus on it) of perioperative analgesic drugs and interventions and an active involvement of the patient in pain therapy (e.g. by using patient-controlled analgesia) might improve acute pain therapy via an additive placebo effect (by around 30%).
AB - Placebo and nocebo effects are currently within the focus of clinical and experimental pain research. Neurophysiological and psychophysiological mechanisms might play an important role. Placebo and nocebo effects might be mediated through the descendent inhibitory pain pathway via endogenous opioids. Apart from that three different psychological mechanisms might be relevant for placebo and nocebo effects: classical conditioning, social learning and pain expectation. An open analgesic drug application, detailed patient information about efficacy and possible adverse events (without an extensive focus on it) of perioperative analgesic drugs and interventions and an active involvement of the patient in pain therapy (e.g. by using patient-controlled analgesia) might improve acute pain therapy via an additive placebo effect (by around 30%).
KW - Acute Pain/therapy
KW - Chronic Pain/therapy
KW - Humans
KW - Hyperalgesia
KW - Nocebo Effect
KW - Pain Management/methods
KW - Placebo Effect
U2 - 10.1055/s-0043-121684
DO - 10.1055/s-0043-121684
M3 - SCORING: Review
C2 - 30176686
VL - 53
SP - 579
EP - 590
JO - ANASTH INTENSIV NOTF
JF - ANASTH INTENSIV NOTF
SN - 0939-2661
IS - 9
ER -