Peroral endoscopic myotomy for the treatment of achalasia: an international prospective multicenter study
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Peroral endoscopic myotomy for the treatment of achalasia: an international prospective multicenter study. / Von Renteln, Daniel; Fuchs, Karl-Hermann; Fockens, Paul; Bauerfeind, Peter; Vassiliou, Melina C; Werner, Yuki-Birgit; Fried, Gerald; Breithaupt, Wolfram; Heinrich, Henriette; Bredenoord, Albert J; Kersten, Jan F; Verlaan, Tessa; Trevisonno, Michael; Rösch, Thomas.
in: GASTROENTEROLOGY, Jahrgang 145, Nr. 2, 01.08.2013, S. 309-11.e1-3.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Peroral endoscopic myotomy for the treatment of achalasia: an international prospective multicenter study
AU - Von Renteln, Daniel
AU - Fuchs, Karl-Hermann
AU - Fockens, Paul
AU - Bauerfeind, Peter
AU - Vassiliou, Melina C
AU - Werner, Yuki-Birgit
AU - Fried, Gerald
AU - Breithaupt, Wolfram
AU - Heinrich, Henriette
AU - Bredenoord, Albert J
AU - Kersten, Jan F
AU - Verlaan, Tessa
AU - Trevisonno, Michael
AU - Rösch, Thomas
N1 - Copyright © 2013 AGA Institute. Published by Elsevier Inc. All rights reserved.
PY - 2013/8/1
Y1 - 2013/8/1
N2 - Pilot studies have indicated that peroral endoscopic myotomy (POEM) might be a safe and effective treatment for achalasia. We performed a prospective, international, multicenter study to determine the outcomes of 70 patients who underwent POEM at 5 centers in Europe and North America. Three months after POEM, 97% of patients were in symptom remission (95% confidence interval, 89%-99%); symptom scores were reduced from 7 to 1 (P < .001) and lower esophageal sphincter pressures were reduced from 28 to 9 mm Hg (P < .001). The percentage of patients in symptom remission at 6 and 12 months was 89% and 82%, respectively. POEM was found to be an effective treatment for achalasia after a mean follow-up period of 10 months.
AB - Pilot studies have indicated that peroral endoscopic myotomy (POEM) might be a safe and effective treatment for achalasia. We performed a prospective, international, multicenter study to determine the outcomes of 70 patients who underwent POEM at 5 centers in Europe and North America. Three months after POEM, 97% of patients were in symptom remission (95% confidence interval, 89%-99%); symptom scores were reduced from 7 to 1 (P < .001) and lower esophageal sphincter pressures were reduced from 28 to 9 mm Hg (P < .001). The percentage of patients in symptom remission at 6 and 12 months was 89% and 82%, respectively. POEM was found to be an effective treatment for achalasia after a mean follow-up period of 10 months.
KW - Adult
KW - Cohort Studies
KW - Esophageal Achalasia
KW - Esophagoscopy
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Natural Orifice Endoscopic Surgery
KW - Prospective Studies
KW - Treatment Outcome
U2 - 10.1053/j.gastro.2013.04.057
DO - 10.1053/j.gastro.2013.04.057
M3 - SCORING: Journal article
C2 - 23665071
VL - 145
SP - 309-11.e1-3
JO - GASTROENTEROLOGY
JF - GASTROENTEROLOGY
SN - 0016-5085
IS - 2
ER -