Paraneoplastic cerebellar degeneration in pediatric Hodgkin disease
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Paraneoplastic cerebellar degeneration in pediatric Hodgkin disease. / Hahn, A; Claviez, A; Brinkmann, G; Altermatt, H J; Schneppenheim, R; Stephani, U.
in: NEUROPEDIATRICS, Jahrgang 31, Nr. 1, 01.02.2000, S. 42-4.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Paraneoplastic cerebellar degeneration in pediatric Hodgkin disease
AU - Hahn, A
AU - Claviez, A
AU - Brinkmann, G
AU - Altermatt, H J
AU - Schneppenheim, R
AU - Stephani, U
PY - 2000/2/1
Y1 - 2000/2/1
N2 - Paraneoplastic cerebellar degeneration (PCD) is a rare neurological complication in adults with extracerebral neoplasms. It is characterized by a diffuse cerebellar dysfunction, usually leading to severe neurological sequelae. In childhood, this complication is extremely rare. We report on PCD as primary manifestation of Hodgkin disease (HD) in a thirteen-year old boy. On magnetic resonance imaging, irreversible atrophy of the cerebellum developed within three months. Antibodies against Purkinje cells were detectable at diagnosis and normalised after successful treatment of the lymphoma. Cerebellar symptoms, however, only partially resolved. The necessity of a search for a malignant tumour is emphasised in the presence of an otherwise unexplained, subacutely developing, diffuse cerebellar dysfunction.
AB - Paraneoplastic cerebellar degeneration (PCD) is a rare neurological complication in adults with extracerebral neoplasms. It is characterized by a diffuse cerebellar dysfunction, usually leading to severe neurological sequelae. In childhood, this complication is extremely rare. We report on PCD as primary manifestation of Hodgkin disease (HD) in a thirteen-year old boy. On magnetic resonance imaging, irreversible atrophy of the cerebellum developed within three months. Antibodies against Purkinje cells were detectable at diagnosis and normalised after successful treatment of the lymphoma. Cerebellar symptoms, however, only partially resolved. The necessity of a search for a malignant tumour is emphasised in the presence of an otherwise unexplained, subacutely developing, diffuse cerebellar dysfunction.
KW - Adolescent
KW - Adult
KW - Cerebellum
KW - Diagnosis, Differential
KW - Follow-Up Studies
KW - Hodgkin Disease
KW - Humans
KW - Magnetic Resonance Imaging
KW - Male
KW - Paraneoplastic Cerebellar Degeneration
U2 - 10.1055/s-2000-15297
DO - 10.1055/s-2000-15297
M3 - SCORING: Journal article
C2 - 10774996
VL - 31
SP - 42
EP - 44
JO - NEUROPEDIATRICS
JF - NEUROPEDIATRICS
SN - 0174-304X
IS - 1
ER -