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Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications in C57BL/6 mice

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Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications in C57BL/6 mice. / Mulay, Shrikant R; Eberhard, Jonathan N; Pfann, Victoria; Marschner, Julian A; Darisipudi, Murthy N; Daniel, Christoph; Romoli, Simone; Desai, Jyaysi; Grigorescu, Melissa; Kumar, Santhosh V; Rathkolb, Birgit; Wolf, Eckhard; Hrabě de Angelis, Martin; Bäuerle, Tobias; Dietel, Barbara; Wagner, Carsten A; Amann, Kerstin; Eckardt, Kai-Uwe; Aronson, Peter S; Anders, Hans Joachim; Knauf, Felix.

in: AM J PHYSIOL-RENAL, Jahrgang 310, Nr. 8, 15.04.2016, S. F785-F795.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Mulay, SR, Eberhard, JN, Pfann, V, Marschner, JA, Darisipudi, MN, Daniel, C, Romoli, S, Desai, J, Grigorescu, M, Kumar, SV, Rathkolb, B, Wolf, E, Hrabě de Angelis, M, Bäuerle, T, Dietel, B, Wagner, CA, Amann, K, Eckardt, K-U, Aronson, PS, Anders, HJ & Knauf, F 2016, 'Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications in C57BL/6 mice', AM J PHYSIOL-RENAL, Jg. 310, Nr. 8, S. F785-F795. https://doi.org/10.1152/ajprenal.00488.2015

APA

Mulay, S. R., Eberhard, J. N., Pfann, V., Marschner, J. A., Darisipudi, M. N., Daniel, C., Romoli, S., Desai, J., Grigorescu, M., Kumar, S. V., Rathkolb, B., Wolf, E., Hrabě de Angelis, M., Bäuerle, T., Dietel, B., Wagner, C. A., Amann, K., Eckardt, K-U., Aronson, P. S., ... Knauf, F. (2016). Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications in C57BL/6 mice. AM J PHYSIOL-RENAL, 310(8), F785-F795. https://doi.org/10.1152/ajprenal.00488.2015

Vancouver

Mulay SR, Eberhard JN, Pfann V, Marschner JA, Darisipudi MN, Daniel C et al. Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications in C57BL/6 mice. AM J PHYSIOL-RENAL. 2016 Apr 15;310(8):F785-F795. https://doi.org/10.1152/ajprenal.00488.2015

Bibtex

@article{d771db14d07e4e1cbd39d8c3b75dcf5e,
title = "Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications in C57BL/6 mice",
abstract = "Chronic kidney disease (CKD) research is limited by the lack of convenient inducible models mimicking human CKD and its complications in experimental animals. We demonstrate that a soluble oxalate-rich diet induces stable stages of CKD in male and female C57BL/6 mice. Renal histology is characterized by tubular damage, remnant atubular glomeruli, interstitial inflammation, and fibrosis, with the extent of tissue involvement depending on the duration of oxalate feeding. Expression profiling of markers and magnetic resonance imaging findings established to reflect inflammation and fibrosis parallel the histological changes. Within 3 wk, the mice reproducibly develop normochromic anemia, metabolic acidosis, hyperkalemia, FGF23 activation, hyperphosphatemia, and hyperparathyroidism. In addition, the model is characterized by profound arterial hypertension as well as cardiac fibrosis that persist following the switch to a control diet. Together, this new model of inducible CKD overcomes a number of previous experimental limitations and should serve useful in research related to CKD and its complications.",
keywords = "Animals, Disease Models, Animal, Fibrosis, Hypertension, Mice, Mice, Inbred C57BL, Myocardium, Oxalic Acid, Renal Insufficiency, Chronic, Uremia, Journal Article",
author = "Mulay, {Shrikant R} and Eberhard, {Jonathan N} and Victoria Pfann and Marschner, {Julian A} and Darisipudi, {Murthy N} and Christoph Daniel and Simone Romoli and Jyaysi Desai and Melissa Grigorescu and Kumar, {Santhosh V} and Birgit Rathkolb and Eckhard Wolf and {Hrab{\v e} de Angelis}, Martin and Tobias B{\"a}uerle and Barbara Dietel and Wagner, {Carsten A} and Kerstin Amann and Kai-Uwe Eckardt and Aronson, {Peter S} and Anders, {Hans Joachim} and Felix Knauf",
note = "Copyright {\textcopyright} 2016 the American Physiological Society.",
year = "2016",
month = apr,
day = "15",
doi = "10.1152/ajprenal.00488.2015",
language = "English",
volume = "310",
pages = "F785--F795",
journal = "AM J PHYSIOL-RENAL",
issn = "1931-857X",
publisher = "AMER PHYSIOLOGICAL SOC",
number = "8",

}

RIS

TY - JOUR

T1 - Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications in C57BL/6 mice

AU - Mulay, Shrikant R

AU - Eberhard, Jonathan N

AU - Pfann, Victoria

AU - Marschner, Julian A

AU - Darisipudi, Murthy N

AU - Daniel, Christoph

AU - Romoli, Simone

AU - Desai, Jyaysi

AU - Grigorescu, Melissa

AU - Kumar, Santhosh V

AU - Rathkolb, Birgit

AU - Wolf, Eckhard

AU - Hrabě de Angelis, Martin

AU - Bäuerle, Tobias

AU - Dietel, Barbara

AU - Wagner, Carsten A

AU - Amann, Kerstin

AU - Eckardt, Kai-Uwe

AU - Aronson, Peter S

AU - Anders, Hans Joachim

AU - Knauf, Felix

N1 - Copyright © 2016 the American Physiological Society.

PY - 2016/4/15

Y1 - 2016/4/15

N2 - Chronic kidney disease (CKD) research is limited by the lack of convenient inducible models mimicking human CKD and its complications in experimental animals. We demonstrate that a soluble oxalate-rich diet induces stable stages of CKD in male and female C57BL/6 mice. Renal histology is characterized by tubular damage, remnant atubular glomeruli, interstitial inflammation, and fibrosis, with the extent of tissue involvement depending on the duration of oxalate feeding. Expression profiling of markers and magnetic resonance imaging findings established to reflect inflammation and fibrosis parallel the histological changes. Within 3 wk, the mice reproducibly develop normochromic anemia, metabolic acidosis, hyperkalemia, FGF23 activation, hyperphosphatemia, and hyperparathyroidism. In addition, the model is characterized by profound arterial hypertension as well as cardiac fibrosis that persist following the switch to a control diet. Together, this new model of inducible CKD overcomes a number of previous experimental limitations and should serve useful in research related to CKD and its complications.

AB - Chronic kidney disease (CKD) research is limited by the lack of convenient inducible models mimicking human CKD and its complications in experimental animals. We demonstrate that a soluble oxalate-rich diet induces stable stages of CKD in male and female C57BL/6 mice. Renal histology is characterized by tubular damage, remnant atubular glomeruli, interstitial inflammation, and fibrosis, with the extent of tissue involvement depending on the duration of oxalate feeding. Expression profiling of markers and magnetic resonance imaging findings established to reflect inflammation and fibrosis parallel the histological changes. Within 3 wk, the mice reproducibly develop normochromic anemia, metabolic acidosis, hyperkalemia, FGF23 activation, hyperphosphatemia, and hyperparathyroidism. In addition, the model is characterized by profound arterial hypertension as well as cardiac fibrosis that persist following the switch to a control diet. Together, this new model of inducible CKD overcomes a number of previous experimental limitations and should serve useful in research related to CKD and its complications.

KW - Animals

KW - Disease Models, Animal

KW - Fibrosis

KW - Hypertension

KW - Mice

KW - Mice, Inbred C57BL

KW - Myocardium

KW - Oxalic Acid

KW - Renal Insufficiency, Chronic

KW - Uremia

KW - Journal Article

U2 - 10.1152/ajprenal.00488.2015

DO - 10.1152/ajprenal.00488.2015

M3 - SCORING: Journal article

C2 - 26764204

VL - 310

SP - F785-F795

JO - AM J PHYSIOL-RENAL

JF - AM J PHYSIOL-RENAL

SN - 1931-857X

IS - 8

ER -