Overexpression of the Raf-1 proto-oncogene in human myeloid leukemia.
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Overexpression of the Raf-1 proto-oncogene in human myeloid leukemia. / Schmidt, C A; Oettle, H; Ludwig, W D; Serke, S; Pawlaczyk-Peter, B; Wilborn, F; Binder, Thomas; Huhn, D; Siegert, W.
in: LEUKEMIA RES, Jahrgang 18, Nr. 6, 6, 1994, S. 409-413.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Overexpression of the Raf-1 proto-oncogene in human myeloid leukemia.
AU - Schmidt, C A
AU - Oettle, H
AU - Ludwig, W D
AU - Serke, S
AU - Pawlaczyk-Peter, B
AU - Wilborn, F
AU - Binder, Thomas
AU - Huhn, D
AU - Siegert, W
PY - 1994
Y1 - 1994
N2 - The Raf-1 protein, a cytoplasmic serine/threonine kinase, plays an important role in signal transduction pathways. In order to examine the role of Raf-1 in human myeloid leukemia, we determined raf-1 mRNA expression by Northern blot analysis in blast cell samples from 27 acute myeloid leukemia (AML) cases and peripheral blood mononuclear cells from six healthy donors. A normal raf-1 transcript size was detected in all cases investigated. However, overexpression of raf-1 mRNA was found in 2 of 27 AML cases, both of which were erythroleukemias (AML, FAB M6).
AB - The Raf-1 protein, a cytoplasmic serine/threonine kinase, plays an important role in signal transduction pathways. In order to examine the role of Raf-1 in human myeloid leukemia, we determined raf-1 mRNA expression by Northern blot analysis in blast cell samples from 27 acute myeloid leukemia (AML) cases and peripheral blood mononuclear cells from six healthy donors. A normal raf-1 transcript size was detected in all cases investigated. However, overexpression of raf-1 mRNA was found in 2 of 27 AML cases, both of which were erythroleukemias (AML, FAB M6).
M3 - SCORING: Zeitschriftenaufsatz
VL - 18
SP - 409
EP - 413
JO - LEUKEMIA RES
JF - LEUKEMIA RES
SN - 0145-2126
IS - 6
M1 - 6
ER -