Osseous changes in meningioma en plaque.
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Osseous changes in meningioma en plaque. / Matschke, Jakob; Addo, Jasmine; Bernreuther, Christian; Zustin, Jozef.
in: ANTICANCER RES, Jahrgang 31, Nr. 2, 2, 2011, S. 591-596.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Osseous changes in meningioma en plaque.
AU - Matschke, Jakob
AU - Addo, Jasmine
AU - Bernreuther, Christian
AU - Zustin, Jozef
PY - 2011
Y1 - 2011
N2 - Hyperostosis is the most common skull change associated with meningioma. Five hyperostosis cases of meningioma en plaque infiltrating the skull processed without previous decalcification of the bone tissue were investigated histologically and immunohistochemically with antibodies against somatostatin receptor 2A (SSR2A). Undecalcified bone biopsies embedded in methylmethacrylate and paraffin-embedded extraosseous tumor tissues were analyzed. All five cases were well-differentiated meningotheliomatous meningiomas en plaque according to the WHO classification of tumors and revealed areas of hyperosteoidosis. Furthermore, all five meningiomas en plaque presented strong positive reactions to antibodies against SSR2A in both the intraosseous and extraosseous tumor proliferates. In summary, similar morphological changes characterized by hyperosteoidosis were observed in a small cohort of meningioma en plaque associated with expression of SSR2A and reports in the literature of the histogenesis of hyperostosis in meningioma en plaque are discussed.
AB - Hyperostosis is the most common skull change associated with meningioma. Five hyperostosis cases of meningioma en plaque infiltrating the skull processed without previous decalcification of the bone tissue were investigated histologically and immunohistochemically with antibodies against somatostatin receptor 2A (SSR2A). Undecalcified bone biopsies embedded in methylmethacrylate and paraffin-embedded extraosseous tumor tissues were analyzed. All five cases were well-differentiated meningotheliomatous meningiomas en plaque according to the WHO classification of tumors and revealed areas of hyperosteoidosis. Furthermore, all five meningiomas en plaque presented strong positive reactions to antibodies against SSR2A in both the intraosseous and extraosseous tumor proliferates. In summary, similar morphological changes characterized by hyperosteoidosis were observed in a small cohort of meningioma en plaque associated with expression of SSR2A and reports in the literature of the histogenesis of hyperostosis in meningioma en plaque are discussed.
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Cohort Studies
KW - Immunohistochemistry
KW - Cell Growth Processes/physiology
KW - Bone and Bones/pathology
KW - Meningeal Neoplasms/metabolism/pathology
KW - Meningioma/metabolism/pathology
KW - Receptors, Somatostatin/metabolism
KW - Skull Neoplasms/metabolism/secondary
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Cohort Studies
KW - Immunohistochemistry
KW - Cell Growth Processes/physiology
KW - Bone and Bones/pathology
KW - Meningeal Neoplasms/metabolism/pathology
KW - Meningioma/metabolism/pathology
KW - Receptors, Somatostatin/metabolism
KW - Skull Neoplasms/metabolism/secondary
M3 - SCORING: Journal article
VL - 31
SP - 591
EP - 596
JO - ANTICANCER RES
JF - ANTICANCER RES
SN - 0250-7005
IS - 2
M1 - 2
ER -
