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Optical diagnosis of oral cavity lesions by label-free Raman spectroscopy

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Optical diagnosis of oral cavity lesions by label-free Raman spectroscopy. / Matthies, Levi; Gebrekidan, Medhanie Tesfay; Tegtmeyer, Jasper F.; Oetter, Nicolai; Rohde, Maximilian; Vollkommer, Tobias; Smeets, Ralf; Wilczak, Waldemar; Stelzle, Florian; Gosau, Martin; Braeuer, Andreas Siegfried; Knipfer, Christian.

in: BIOMED OPT EXPRESS, Jahrgang 12, Nr. 2, 01.02.2021, S. 836-851.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Matthies, L, Gebrekidan, MT, Tegtmeyer, JF, Oetter, N, Rohde, M, Vollkommer, T, Smeets, R, Wilczak, W, Stelzle, F, Gosau, M, Braeuer, AS & Knipfer, C 2021, 'Optical diagnosis of oral cavity lesions by label-free Raman spectroscopy', BIOMED OPT EXPRESS, Jg. 12, Nr. 2, S. 836-851. https://doi.org/10.1364/BOE.409456

APA

Matthies, L., Gebrekidan, M. T., Tegtmeyer, J. F., Oetter, N., Rohde, M., Vollkommer, T., Smeets, R., Wilczak, W., Stelzle, F., Gosau, M., Braeuer, A. S., & Knipfer, C. (2021). Optical diagnosis of oral cavity lesions by label-free Raman spectroscopy. BIOMED OPT EXPRESS, 12(2), 836-851. https://doi.org/10.1364/BOE.409456

Vancouver

Matthies L, Gebrekidan MT, Tegtmeyer JF, Oetter N, Rohde M, Vollkommer T et al. Optical diagnosis of oral cavity lesions by label-free Raman spectroscopy. BIOMED OPT EXPRESS. 2021 Feb 1;12(2):836-851. https://doi.org/10.1364/BOE.409456

Bibtex

@article{ed24a8e44a064cbf9d658e125671c024,
title = "Optical diagnosis of oral cavity lesions by label-free Raman spectroscopy",
abstract = "Oral squamous cell carcinoma (OSCC) is one of the most prevalent cancers and frequently preceded by non-malignant lesions. Using Shifted-Excitation Raman Difference Spectroscopy (SERDS), principal component and linear discriminant analysis in native tissue specimens, 9500 raw Raman spectra of OSCC, 4300 of non-malignant lesions and 4200 of physiological mucosa were evaluated. Non-malignant lesions were distinguished from physiological mucosa with a classification accuracy of 95.3% (95.4% sensitivity, 95.2% specificity, area under the curve (AUC) 0.99). Discriminating OSCC from non-malignant lesions showed an accuracy of 88.4% (93.7% sensitivity, 76.7% specificity, AUC 0.93). OSCC was identified against physiological mucosa with an accuracy of 89.8% (93.7% sensitivity, 81.0% specificity, AUC 0.90). These findings underline the potential of SERDS for the diagnosis of oral cavity lesions.",
author = "Levi Matthies and Gebrekidan, {Medhanie Tesfay} and Tegtmeyer, {Jasper F.} and Nicolai Oetter and Maximilian Rohde and Tobias Vollkommer and Ralf Smeets and Waldemar Wilczak and Florian Stelzle and Martin Gosau and Braeuer, {Andreas Siegfried} and Christian Knipfer",
year = "2021",
month = feb,
day = "1",
doi = "10.1364/BOE.409456",
language = "English",
volume = "12",
pages = "836--851",
journal = "BIOMED OPT EXPRESS",
issn = "2156-7085",
publisher = "The Optical Society",
number = "2",

}

RIS

TY - JOUR

T1 - Optical diagnosis of oral cavity lesions by label-free Raman spectroscopy

AU - Matthies, Levi

AU - Gebrekidan, Medhanie Tesfay

AU - Tegtmeyer, Jasper F.

AU - Oetter, Nicolai

AU - Rohde, Maximilian

AU - Vollkommer, Tobias

AU - Smeets, Ralf

AU - Wilczak, Waldemar

AU - Stelzle, Florian

AU - Gosau, Martin

AU - Braeuer, Andreas Siegfried

AU - Knipfer, Christian

PY - 2021/2/1

Y1 - 2021/2/1

N2 - Oral squamous cell carcinoma (OSCC) is one of the most prevalent cancers and frequently preceded by non-malignant lesions. Using Shifted-Excitation Raman Difference Spectroscopy (SERDS), principal component and linear discriminant analysis in native tissue specimens, 9500 raw Raman spectra of OSCC, 4300 of non-malignant lesions and 4200 of physiological mucosa were evaluated. Non-malignant lesions were distinguished from physiological mucosa with a classification accuracy of 95.3% (95.4% sensitivity, 95.2% specificity, area under the curve (AUC) 0.99). Discriminating OSCC from non-malignant lesions showed an accuracy of 88.4% (93.7% sensitivity, 76.7% specificity, AUC 0.93). OSCC was identified against physiological mucosa with an accuracy of 89.8% (93.7% sensitivity, 81.0% specificity, AUC 0.90). These findings underline the potential of SERDS for the diagnosis of oral cavity lesions.

AB - Oral squamous cell carcinoma (OSCC) is one of the most prevalent cancers and frequently preceded by non-malignant lesions. Using Shifted-Excitation Raman Difference Spectroscopy (SERDS), principal component and linear discriminant analysis in native tissue specimens, 9500 raw Raman spectra of OSCC, 4300 of non-malignant lesions and 4200 of physiological mucosa were evaluated. Non-malignant lesions were distinguished from physiological mucosa with a classification accuracy of 95.3% (95.4% sensitivity, 95.2% specificity, area under the curve (AUC) 0.99). Discriminating OSCC from non-malignant lesions showed an accuracy of 88.4% (93.7% sensitivity, 76.7% specificity, AUC 0.93). OSCC was identified against physiological mucosa with an accuracy of 89.8% (93.7% sensitivity, 81.0% specificity, AUC 0.90). These findings underline the potential of SERDS for the diagnosis of oral cavity lesions.

U2 - 10.1364/BOE.409456

DO - 10.1364/BOE.409456

M3 - SCORING: Journal article

VL - 12

SP - 836

EP - 851

JO - BIOMED OPT EXPRESS

JF - BIOMED OPT EXPRESS

SN - 2156-7085

IS - 2

ER -