One fatal and one nonfatal intoxication with tranylcypromine. Absence of amphetamines as metabolites.
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One fatal and one nonfatal intoxication with tranylcypromine. Absence of amphetamines as metabolites. / Iwersen-Bergmann, Stefanie; Schmoldt, A.
in: J ANAL TOXICOL, Jahrgang 20, Nr. 5, 5, 1996, S. 301-304.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - One fatal and one nonfatal intoxication with tranylcypromine. Absence of amphetamines as metabolites.
AU - Iwersen-Bergmann, Stefanie
AU - Schmoldt, A
PY - 1996
Y1 - 1996
N2 - Two very different cases of overdose with tranylcypromine are presented. One clinical case involving the ingestion of 400 mg tranylcypromine with suicidal intention and one fatality with a suspicion of possible tranylcypromine overdose were examined. Both cases showed similar blood concentrations (0.5 and 0.7 mg/L, respectively), but the clinical case exhibited only mild symptoms of intoxication. The fatality showed no other drugs that could provide an explanation for the death of a 40-year-old male except tranylcypromine. Consideration of the drug concentrations in the fatality in relation to the case findings and other reported data indicates the tranylcypromine overdose as the probable cause of death, despite the low blood concentration. In addition, we looked for evidence of amphetamine as a putative metabolite in both cases. No amphetamines were detected in the overdose cases reported here.
AB - Two very different cases of overdose with tranylcypromine are presented. One clinical case involving the ingestion of 400 mg tranylcypromine with suicidal intention and one fatality with a suspicion of possible tranylcypromine overdose were examined. Both cases showed similar blood concentrations (0.5 and 0.7 mg/L, respectively), but the clinical case exhibited only mild symptoms of intoxication. The fatality showed no other drugs that could provide an explanation for the death of a 40-year-old male except tranylcypromine. Consideration of the drug concentrations in the fatality in relation to the case findings and other reported data indicates the tranylcypromine overdose as the probable cause of death, despite the low blood concentration. In addition, we looked for evidence of amphetamine as a putative metabolite in both cases. No amphetamines were detected in the overdose cases reported here.
KW - Adult
KW - Humans
KW - Male
KW - Fatal Outcome
KW - Suicide
KW - Amphetamines/analysis/chemistry/metabolism
KW - Gas Chromatography-Mass Spectrometry/methods
KW - Monoamine Oxidase Inhibitors/chemistry/metabolism/poisoning
KW - Tranylcypromine/chemistry/metabolism/poisoning
KW - Adult
KW - Humans
KW - Male
KW - Fatal Outcome
KW - Suicide
KW - Amphetamines/analysis/chemistry/metabolism
KW - Gas Chromatography-Mass Spectrometry/methods
KW - Monoamine Oxidase Inhibitors/chemistry/metabolism/poisoning
KW - Tranylcypromine/chemistry/metabolism/poisoning
M3 - SCORING: Journal article
VL - 20
SP - 301
EP - 304
JO - J ANAL TOXICOL
JF - J ANAL TOXICOL
SN - 0146-4760
IS - 5
M1 - 5
ER -