O-GlcNAcylation in the osteoblast lineage-boosting the complexity of Wnt-stimulated bone formation

TY - JOUR

T1 - O-GlcNAcylation in the osteoblast lineage-boosting the complexity of Wnt-stimulated bone formation

AU - Pohl, Sandra

AU - Schinke, Thorsten

PY - 2024/10

Y1 - 2024/10

N2 - Although differentiation and activity of bone-forming osteoblasts are regulated at various levels, there is ample evidence that components of the Wnt signaling pathway play a dominant role in bone mass acquisition. Moreover, a neutralizing antibody blocking the Wnt signaling inhibitor sclerostin has recently been established as a novel osteoanabolic treatment option for osteoporotic patients. Importantly, however, the molecular mechanisms explaining the osteogenic influence of Wnt molecules are still not fully clarified. In this issue of EMBO Reports, You and co-workers show that O-GlcNAcylation is required for the osteoanabolic effect of Wnt stimulation, in vitro and in vivo (You et al, 2024).

AB - Although differentiation and activity of bone-forming osteoblasts are regulated at various levels, there is ample evidence that components of the Wnt signaling pathway play a dominant role in bone mass acquisition. Moreover, a neutralizing antibody blocking the Wnt signaling inhibitor sclerostin has recently been established as a novel osteoanabolic treatment option for osteoporotic patients. Importantly, however, the molecular mechanisms explaining the osteogenic influence of Wnt molecules are still not fully clarified. In this issue of EMBO Reports, You and co-workers show that O-GlcNAcylation is required for the osteoanabolic effect of Wnt stimulation, in vitro and in vivo (You et al, 2024).

U2 - 10.1038/s44319-024-00242-2

DO - 10.1038/s44319-024-00242-2

M3 - SCORING: Journal article

C2 - 39256594

VL - 25

SP - 4110

EP - 4112

JO - EMBO REP

JF - EMBO REP

SN - 1469-221X

IS - 10

ER -