Obesity and diabetes mellitus are associated with SARS-CoV-2 outcomes without influencing signature genes of extrapulmonary immune compartments at the RNA level
Standard
Obesity and diabetes mellitus are associated with SARS-CoV-2 outcomes without influencing signature genes of extrapulmonary immune compartments at the RNA level. / Lücke, Jöran; Böttcher, Marius; Nawrocki, Mikolaj; Meins, Nicholas; Schnell, Josa; Heinrich, Fabian; Bertram, Franziska; Sabihi, Morsal; Seeger, Philipp; Pfaff, Marie; Notz, Sara; Blankenburg, Tom; Zhang, Tao; Kempski, Jan; Reeh, Matthias; Wolter, Stefan; Mann, Oliver; Lütgehetmann, Marc; Hackert, Thilo; Izbicki, Jakob R; Duprée, Anna; Huber, Samuel; Ondruschka, Benjamin; Giannou, Anastasios D.
in: HELIYON, Jahrgang 10, Nr. 2, 30.01.2024, S. e24508.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Obesity and diabetes mellitus are associated with SARS-CoV-2 outcomes without influencing signature genes of extrapulmonary immune compartments at the RNA level
AU - Lücke, Jöran
AU - Böttcher, Marius
AU - Nawrocki, Mikolaj
AU - Meins, Nicholas
AU - Schnell, Josa
AU - Heinrich, Fabian
AU - Bertram, Franziska
AU - Sabihi, Morsal
AU - Seeger, Philipp
AU - Pfaff, Marie
AU - Notz, Sara
AU - Blankenburg, Tom
AU - Zhang, Tao
AU - Kempski, Jan
AU - Reeh, Matthias
AU - Wolter, Stefan
AU - Mann, Oliver
AU - Lütgehetmann, Marc
AU - Hackert, Thilo
AU - Izbicki, Jakob R
AU - Duprée, Anna
AU - Huber, Samuel
AU - Ondruschka, Benjamin
AU - Giannou, Anastasios D
N1 - © 2024 The Authors.
PY - 2024/1/30
Y1 - 2024/1/30
N2 - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which is responsible for eliciting Coronavirus disease 2019 (COVID-19) still challenges healthcare services worldwide. While many patients only suffer from mild symptoms, patients with some pre-existing medical conditions are at a higher risk for a detrimental course of disease. However, the underlying mechanisms determining disease course are only partially understood. One key factor influencing disease severity is described to be immune-mediated. In this report, we describe a post-mortem analysis of 45 individuals who died from SARS-CoV-2 infection. We could show that although sociodemographic factors and premedical conditions such as obesity and diabetes mellitus reduced survival time in our cohort, they were not associated with changes in the expression of immune-related signature genes at the RNA level in the blood, the gut, or the liver between these different groups. Our data indicate that obesity and diabetes mellitus influence SARS-CoV-2-related mortality, without influencing the extrapulmonary gene expression of immunity-related signature genes at the RNA level.
AB - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which is responsible for eliciting Coronavirus disease 2019 (COVID-19) still challenges healthcare services worldwide. While many patients only suffer from mild symptoms, patients with some pre-existing medical conditions are at a higher risk for a detrimental course of disease. However, the underlying mechanisms determining disease course are only partially understood. One key factor influencing disease severity is described to be immune-mediated. In this report, we describe a post-mortem analysis of 45 individuals who died from SARS-CoV-2 infection. We could show that although sociodemographic factors and premedical conditions such as obesity and diabetes mellitus reduced survival time in our cohort, they were not associated with changes in the expression of immune-related signature genes at the RNA level in the blood, the gut, or the liver between these different groups. Our data indicate that obesity and diabetes mellitus influence SARS-CoV-2-related mortality, without influencing the extrapulmonary gene expression of immunity-related signature genes at the RNA level.
U2 - 10.1016/j.heliyon.2024.e24508
DO - 10.1016/j.heliyon.2024.e24508
M3 - SCORING: Journal article
C2 - 38298642
VL - 10
SP - e24508
JO - HELIYON
JF - HELIYON
SN - 2405-8440
IS - 2
ER -