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Obesity and diabetes mellitus are associated with SARS-CoV-2 outcomes without influencing signature genes of extrapulmonary immune compartments at the RNA level

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Obesity and diabetes mellitus are associated with SARS-CoV-2 outcomes without influencing signature genes of extrapulmonary immune compartments at the RNA level. / Lücke, Jöran; Böttcher, Marius; Nawrocki, Mikolaj; Meins, Nicholas; Schnell, Josa; Heinrich, Fabian; Bertram, Franziska; Sabihi, Morsal; Seeger, Philipp; Pfaff, Marie; Notz, Sara; Blankenburg, Tom; Zhang, Tao; Kempski, Jan; Reeh, Matthias; Wolter, Stefan; Mann, Oliver; Lütgehetmann, Marc; Hackert, Thilo; Izbicki, Jakob R; Duprée, Anna; Huber, Samuel; Ondruschka, Benjamin; Giannou, Anastasios D.

in: HELIYON, Jahrgang 10, Nr. 2, 30.01.2024, S. e24508.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Lücke, J, Böttcher, M, Nawrocki, M, Meins, N, Schnell, J, Heinrich, F, Bertram, F, Sabihi, M, Seeger, P, Pfaff, M, Notz, S, Blankenburg, T, Zhang, T, Kempski, J, Reeh, M, Wolter, S, Mann, O, Lütgehetmann, M, Hackert, T, Izbicki, JR, Duprée, A, Huber, S, Ondruschka, B & Giannou, AD 2024, 'Obesity and diabetes mellitus are associated with SARS-CoV-2 outcomes without influencing signature genes of extrapulmonary immune compartments at the RNA level', HELIYON, Jg. 10, Nr. 2, S. e24508. https://doi.org/10.1016/j.heliyon.2024.e24508

APA

Lücke, J., Böttcher, M., Nawrocki, M., Meins, N., Schnell, J., Heinrich, F., Bertram, F., Sabihi, M., Seeger, P., Pfaff, M., Notz, S., Blankenburg, T., Zhang, T., Kempski, J., Reeh, M., Wolter, S., Mann, O., Lütgehetmann, M., Hackert, T., ... Giannou, A. D. (2024). Obesity and diabetes mellitus are associated with SARS-CoV-2 outcomes without influencing signature genes of extrapulmonary immune compartments at the RNA level. HELIYON, 10(2), e24508. https://doi.org/10.1016/j.heliyon.2024.e24508

Vancouver

Lücke J, Böttcher M, Nawrocki M, Meins N, Schnell J, Heinrich F et al. Obesity and diabetes mellitus are associated with SARS-CoV-2 outcomes without influencing signature genes of extrapulmonary immune compartments at the RNA level. HELIYON. 2024 Jan 30;10(2):e24508. https://doi.org/10.1016/j.heliyon.2024.e24508

Bibtex

@article{afe9b6c9ac2340eba917793032acbe3a,
title = "Obesity and diabetes mellitus are associated with SARS-CoV-2 outcomes without influencing signature genes of extrapulmonary immune compartments at the RNA level",
abstract = "The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which is responsible for eliciting Coronavirus disease 2019 (COVID-19) still challenges healthcare services worldwide. While many patients only suffer from mild symptoms, patients with some pre-existing medical conditions are at a higher risk for a detrimental course of disease. However, the underlying mechanisms determining disease course are only partially understood. One key factor influencing disease severity is described to be immune-mediated. In this report, we describe a post-mortem analysis of 45 individuals who died from SARS-CoV-2 infection. We could show that although sociodemographic factors and premedical conditions such as obesity and diabetes mellitus reduced survival time in our cohort, they were not associated with changes in the expression of immune-related signature genes at the RNA level in the blood, the gut, or the liver between these different groups. Our data indicate that obesity and diabetes mellitus influence SARS-CoV-2-related mortality, without influencing the extrapulmonary gene expression of immunity-related signature genes at the RNA level.",
author = "J{\"o}ran L{\"u}cke and Marius B{\"o}ttcher and Mikolaj Nawrocki and Nicholas Meins and Josa Schnell and Fabian Heinrich and Franziska Bertram and Morsal Sabihi and Philipp Seeger and Marie Pfaff and Sara Notz and Tom Blankenburg and Tao Zhang and Jan Kempski and Matthias Reeh and Stefan Wolter and Oliver Mann and Marc L{\"u}tgehetmann and Thilo Hackert and Izbicki, {Jakob R} and Anna Dupr{\'e}e and Samuel Huber and Benjamin Ondruschka and Giannou, {Anastasios D}",
note = "{\textcopyright} 2024 The Authors.",
year = "2024",
month = jan,
day = "30",
doi = "10.1016/j.heliyon.2024.e24508",
language = "English",
volume = "10",
pages = "e24508",
journal = "HELIYON",
issn = "2405-8440",
publisher = "Elsevier BV",
number = "2",

}

RIS

TY - JOUR

T1 - Obesity and diabetes mellitus are associated with SARS-CoV-2 outcomes without influencing signature genes of extrapulmonary immune compartments at the RNA level

AU - Lücke, Jöran

AU - Böttcher, Marius

AU - Nawrocki, Mikolaj

AU - Meins, Nicholas

AU - Schnell, Josa

AU - Heinrich, Fabian

AU - Bertram, Franziska

AU - Sabihi, Morsal

AU - Seeger, Philipp

AU - Pfaff, Marie

AU - Notz, Sara

AU - Blankenburg, Tom

AU - Zhang, Tao

AU - Kempski, Jan

AU - Reeh, Matthias

AU - Wolter, Stefan

AU - Mann, Oliver

AU - Lütgehetmann, Marc

AU - Hackert, Thilo

AU - Izbicki, Jakob R

AU - Duprée, Anna

AU - Huber, Samuel

AU - Ondruschka, Benjamin

AU - Giannou, Anastasios D

N1 - © 2024 The Authors.

PY - 2024/1/30

Y1 - 2024/1/30

N2 - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which is responsible for eliciting Coronavirus disease 2019 (COVID-19) still challenges healthcare services worldwide. While many patients only suffer from mild symptoms, patients with some pre-existing medical conditions are at a higher risk for a detrimental course of disease. However, the underlying mechanisms determining disease course are only partially understood. One key factor influencing disease severity is described to be immune-mediated. In this report, we describe a post-mortem analysis of 45 individuals who died from SARS-CoV-2 infection. We could show that although sociodemographic factors and premedical conditions such as obesity and diabetes mellitus reduced survival time in our cohort, they were not associated with changes in the expression of immune-related signature genes at the RNA level in the blood, the gut, or the liver between these different groups. Our data indicate that obesity and diabetes mellitus influence SARS-CoV-2-related mortality, without influencing the extrapulmonary gene expression of immunity-related signature genes at the RNA level.

AB - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which is responsible for eliciting Coronavirus disease 2019 (COVID-19) still challenges healthcare services worldwide. While many patients only suffer from mild symptoms, patients with some pre-existing medical conditions are at a higher risk for a detrimental course of disease. However, the underlying mechanisms determining disease course are only partially understood. One key factor influencing disease severity is described to be immune-mediated. In this report, we describe a post-mortem analysis of 45 individuals who died from SARS-CoV-2 infection. We could show that although sociodemographic factors and premedical conditions such as obesity and diabetes mellitus reduced survival time in our cohort, they were not associated with changes in the expression of immune-related signature genes at the RNA level in the blood, the gut, or the liver between these different groups. Our data indicate that obesity and diabetes mellitus influence SARS-CoV-2-related mortality, without influencing the extrapulmonary gene expression of immunity-related signature genes at the RNA level.

U2 - 10.1016/j.heliyon.2024.e24508

DO - 10.1016/j.heliyon.2024.e24508

M3 - SCORING: Journal article

C2 - 38298642

VL - 10

SP - e24508

JO - HELIYON

JF - HELIYON

SN - 2405-8440

IS - 2

ER -