Non-response of cortisol during stressful exposure therapy in patients with obsessive-compulsive disorder--preliminary results.
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Non-response of cortisol during stressful exposure therapy in patients with obsessive-compulsive disorder--preliminary results. / Kellner, Michael; Wiedemann, Klaus; Yassouridis, Alexander; Muhtz, Christoph.
in: PSYCHIAT RES, Jahrgang 199, Nr. 2, 2, 2012, S. 111-114.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Non-response of cortisol during stressful exposure therapy in patients with obsessive-compulsive disorder--preliminary results.
AU - Kellner, Michael
AU - Wiedemann, Klaus
AU - Yassouridis, Alexander
AU - Muhtz, Christoph
PY - 2012
Y1 - 2012
N2 - Exposure with response prevention (ERP) is an established treatment for patients with obsessive-compulsive disorder (OCD) and also an interesting model to characterize neuroendocrine response to psychological stress. However, so far few studies have assessed hypothalamic-pituitary-adrenocortical (HPA) function during ERP and results are inconsistent. In 15 patients with OCD we repeatedly measured salivary cortisol and subjective units of distress (SUD) on two consecutive afternoons. The first day served as a comparison condition; on the second day the very first session of ERP took place. While SUD were significantly increased during ERP versus the comparison day, salivary cortisol was statistically indistinguishable between ERP and comparison conditions before, during and after ERP. Thus, despite considerable psychological stress no increase of cortisol was observed. This response pattern to ERP in OCD patients needs further research.
AB - Exposure with response prevention (ERP) is an established treatment for patients with obsessive-compulsive disorder (OCD) and also an interesting model to characterize neuroendocrine response to psychological stress. However, so far few studies have assessed hypothalamic-pituitary-adrenocortical (HPA) function during ERP and results are inconsistent. In 15 patients with OCD we repeatedly measured salivary cortisol and subjective units of distress (SUD) on two consecutive afternoons. The first day served as a comparison condition; on the second day the very first session of ERP took place. While SUD were significantly increased during ERP versus the comparison day, salivary cortisol was statistically indistinguishable between ERP and comparison conditions before, during and after ERP. Thus, despite considerable psychological stress no increase of cortisol was observed. This response pattern to ERP in OCD patients needs further research.
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Adolescent
KW - Young Adult
KW - Saliva/chemistry
KW - Hydrocortisone/analysis/physiology
KW - Implosive Therapy
KW - Obsessive-Compulsive Disorder/physiopathology/psychology/therapy
KW - Stress, Psychological/physiopathology/psychology
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Adolescent
KW - Young Adult
KW - Saliva/chemistry
KW - Hydrocortisone/analysis/physiology
KW - Implosive Therapy
KW - Obsessive-Compulsive Disorder/physiopathology/psychology/therapy
KW - Stress, Psychological/physiopathology/psychology
M3 - SCORING: Journal article
VL - 199
SP - 111
EP - 114
JO - PSYCHIAT RES
JF - PSYCHIAT RES
SN - 0165-1781
IS - 2
M1 - 2
ER -
