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NK Cells, Monocytes and Macrophages in HIV-1 Control: Impact of Innate Immune Responses

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NK Cells, Monocytes and Macrophages in HIV-1 Control: Impact of Innate Immune Responses. / Mensching, Leonore; Hölzemer, Angelique.

in: FRONT IMMUNOL, Jahrgang 13, 883728, 2022.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Mensching, L & Hölzemer, A 2022, 'NK Cells, Monocytes and Macrophages in HIV-1 Control: Impact of Innate Immune Responses', FRONT IMMUNOL, Jg. 13, 883728. https://doi.org/10.3389/fimmu.2022.883728

APA

Mensching, L., & Hölzemer, A. (2022). NK Cells, Monocytes and Macrophages in HIV-1 Control: Impact of Innate Immune Responses. FRONT IMMUNOL, 13, [883728]. https://doi.org/10.3389/fimmu.2022.883728

Vancouver

Mensching L, Hölzemer A. NK Cells, Monocytes and Macrophages in HIV-1 Control: Impact of Innate Immune Responses. FRONT IMMUNOL. 2022;13. 883728. https://doi.org/10.3389/fimmu.2022.883728

Bibtex

@article{9b598dcb6e3945ed90ae948060ca1a32,
title = "NK Cells, Monocytes and Macrophages in HIV-1 Control: Impact of Innate Immune Responses",
abstract = "Rapid and synchronized responses of innate immune cells are an integral part of managing viral spread in acute virus infections. In human immunodeficiency virus type 1 (HIV-1) infection, increased immune control has been associated with the expression of certain natural killer (NK) cell receptors. Further, immune activation of monocytes/macrophages and the presence of specific cytokines was linked to low levels of HIV-1 replication. In addition to the intrinsic antiviral capabilities of NK cells and monocytes/macrophages, interaction between these cell types has been shown to substantially enhance NK cell function in the context of viral infections. This review discusses the involvement of NK cells and monocytes/macrophages in the effective control of HIV-1 and highlights aspects of innate immune crosstalk in viral infections that may be of relevance to HIV-1 infection.",
keywords = "HIV Infections, HIV-1, Humans, Immunity, Innate, Killer Cells, Natural, Macrophages, Monocytes, Virus Diseases/metabolism",
author = "Leonore Mensching and Angelique H{\"o}lzemer",
note = "Copyright {\textcopyright} 2022 Mensching and Hoelzemer.",
year = "2022",
doi = "10.3389/fimmu.2022.883728",
language = "English",
volume = "13",
journal = "FRONT IMMUNOL",
issn = "1664-3224",
publisher = "Lausanne : Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - NK Cells, Monocytes and Macrophages in HIV-1 Control: Impact of Innate Immune Responses

AU - Mensching, Leonore

AU - Hölzemer, Angelique

N1 - Copyright © 2022 Mensching and Hoelzemer.

PY - 2022

Y1 - 2022

N2 - Rapid and synchronized responses of innate immune cells are an integral part of managing viral spread in acute virus infections. In human immunodeficiency virus type 1 (HIV-1) infection, increased immune control has been associated with the expression of certain natural killer (NK) cell receptors. Further, immune activation of monocytes/macrophages and the presence of specific cytokines was linked to low levels of HIV-1 replication. In addition to the intrinsic antiviral capabilities of NK cells and monocytes/macrophages, interaction between these cell types has been shown to substantially enhance NK cell function in the context of viral infections. This review discusses the involvement of NK cells and monocytes/macrophages in the effective control of HIV-1 and highlights aspects of innate immune crosstalk in viral infections that may be of relevance to HIV-1 infection.

AB - Rapid and synchronized responses of innate immune cells are an integral part of managing viral spread in acute virus infections. In human immunodeficiency virus type 1 (HIV-1) infection, increased immune control has been associated with the expression of certain natural killer (NK) cell receptors. Further, immune activation of monocytes/macrophages and the presence of specific cytokines was linked to low levels of HIV-1 replication. In addition to the intrinsic antiviral capabilities of NK cells and monocytes/macrophages, interaction between these cell types has been shown to substantially enhance NK cell function in the context of viral infections. This review discusses the involvement of NK cells and monocytes/macrophages in the effective control of HIV-1 and highlights aspects of innate immune crosstalk in viral infections that may be of relevance to HIV-1 infection.

KW - HIV Infections

KW - HIV-1

KW - Humans

KW - Immunity, Innate

KW - Killer Cells, Natural

KW - Macrophages

KW - Monocytes

KW - Virus Diseases/metabolism

U2 - 10.3389/fimmu.2022.883728

DO - 10.3389/fimmu.2022.883728

M3 - SCORING: Review article

C2 - 35711433

VL - 13

JO - FRONT IMMUNOL

JF - FRONT IMMUNOL

SN - 1664-3224

M1 - 883728

ER -