New Scheimpflug Dynamic In Vivo Curve Analyses to Characterize Biomechanical Changes of the Cornea After Cross-linking for Progressive Keratoconus
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New Scheimpflug Dynamic In Vivo Curve Analyses to Characterize Biomechanical Changes of the Cornea After Cross-linking for Progressive Keratoconus. / Steinberg, Johannes; Frings, Andreas; Mousli, Aiham; Casagrande, Maria K; Druchkiv, Vasyl; Katz, Toam; Linke, Stephan J.
in: J REFRACT SURG, Jahrgang 32, Nr. 1, 01.2016, S. 34-9.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - New Scheimpflug Dynamic In Vivo Curve Analyses to Characterize Biomechanical Changes of the Cornea After Cross-linking for Progressive Keratoconus
AU - Steinberg, Johannes
AU - Frings, Andreas
AU - Mousli, Aiham
AU - Casagrande, Maria K
AU - Druchkiv, Vasyl
AU - Katz, Toam
AU - Linke, Stephan J
N1 - Copyright 2016, SLACK Incorporated.
PY - 2016/1
Y1 - 2016/1
N2 - PURPOSE: To evaluate the effect of corneal cross-linking (CXL) in progressive keratoconus by applying in vivo static and dynamic Scheimpflug analyses.METHODS: In this longitudinal retrospective study, corneal topography and tomography (Pentacam HD) and dynamic Scheimpflug-based biomechanical analyses (CorvisST [CST]) of 24 eyes of 24 patients with progressive keratoconus before and 6 months after CXL were reviewed. New dynamic curve analyses, provided by Oculus Optikgeräte, were performed to analyze corneal dynamics throughout the entire response to the CST air puff impulse.RESULTS: Besides subtle changes of topography and tomography, only the CorvisST predefined parameters peak distance (-0.5 mm) and radius of the intended cornea (+0.5 mm; P < .05) demonstrated statistically significant differences 6 months after CXL. Using new dynamic curve analyses, additional distinct changes of the corneal biomechanical characteristics after CXL were noted.CONCLUSIONS: Published results of corneal biomechanical changes after CXL for progressive keratoconus based on single, predefined CST parameters are inconsistent. The new dynamic curve analyses demonstrate distinct changes of the biomechanical properties of the cornea and might therefore be the next step in understanding in vivo analyses of corneal biomechanics.
AB - PURPOSE: To evaluate the effect of corneal cross-linking (CXL) in progressive keratoconus by applying in vivo static and dynamic Scheimpflug analyses.METHODS: In this longitudinal retrospective study, corneal topography and tomography (Pentacam HD) and dynamic Scheimpflug-based biomechanical analyses (CorvisST [CST]) of 24 eyes of 24 patients with progressive keratoconus before and 6 months after CXL were reviewed. New dynamic curve analyses, provided by Oculus Optikgeräte, were performed to analyze corneal dynamics throughout the entire response to the CST air puff impulse.RESULTS: Besides subtle changes of topography and tomography, only the CorvisST predefined parameters peak distance (-0.5 mm) and radius of the intended cornea (+0.5 mm; P < .05) demonstrated statistically significant differences 6 months after CXL. Using new dynamic curve analyses, additional distinct changes of the corneal biomechanical characteristics after CXL were noted.CONCLUSIONS: Published results of corneal biomechanical changes after CXL for progressive keratoconus based on single, predefined CST parameters are inconsistent. The new dynamic curve analyses demonstrate distinct changes of the biomechanical properties of the cornea and might therefore be the next step in understanding in vivo analyses of corneal biomechanics.
KW - Adolescent
KW - Adult
KW - Biomechanical Phenomena
KW - Collagen
KW - Cornea
KW - Corneal Stroma
KW - Corneal Topography
KW - Cross-Linking Reagents
KW - Elasticity
KW - Female
KW - Humans
KW - Keratoconus
KW - Longitudinal Studies
KW - Male
KW - Middle Aged
KW - Photochemotherapy
KW - Photosensitizing Agents
KW - Refraction, Ocular
KW - Retrospective Studies
KW - Riboflavin
KW - Tomography
KW - Ultraviolet Rays
KW - Visual Acuity
KW - Young Adult
KW - Journal Article
U2 - 10.3928/1081597X-20151207-09
DO - 10.3928/1081597X-20151207-09
M3 - SCORING: Journal article
C2 - 26812712
VL - 32
SP - 34
EP - 39
JO - J REFRACT SURG
JF - J REFRACT SURG
SN - 1081-597X
IS - 1
ER -