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Neuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin 1 type III signalling

Standard

Neuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin 1 type III signalling. / Schulz, Alexander; Kyselyova, Anna; Baader, Stephan L; Jung, Marie Juliane; Zoch, Ansgar; Mautner, Victor-Felix; Hagel, Christian; Morrison, Helen.

in: BRAIN, Jahrgang 137, Nr. 2, 01.02.2014, S. 420-32.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schulz, A, Kyselyova, A, Baader, SL, Jung, MJ, Zoch, A, Mautner, V-F, Hagel, C & Morrison, H 2014, 'Neuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin 1 type III signalling', BRAIN, Jg. 137, Nr. 2, S. 420-32. https://doi.org/10.1093/brain/awt327

APA

Schulz, A., Kyselyova, A., Baader, S. L., Jung, M. J., Zoch, A., Mautner, V-F., Hagel, C., & Morrison, H. (2014). Neuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin 1 type III signalling. BRAIN, 137(2), 420-32. https://doi.org/10.1093/brain/awt327

Vancouver

Schulz A, Kyselyova A, Baader SL, Jung MJ, Zoch A, Mautner V-F et al. Neuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin 1 type III signalling. BRAIN. 2014 Feb 1;137(2):420-32. https://doi.org/10.1093/brain/awt327

Bibtex

@article{facbefc6f1c147a585754171b704f00f,
title = "Neuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin 1 type III signalling",
abstract = "Axonal surface proteins encompass a group of heterogeneous molecules, which exert a variety of different functions in the highly interdependent relationship between axons and Schwann cells. We recently revealed that the tumour suppressor protein merlin, mutated in the hereditary tumour syndrome neurofibromatosis type 2, impacts significantly on axon structure maintenance in the peripheral nervous system. We now report on a role of neuronal merlin in the regulation of the axonal surface protein neuregulin 1 important for modulating Schwann cell differentiation and myelination. Specifically, neuregulin 1 type III expression is reduced in sciatic nerve tissue of neuron-specific knockout animals as well as in biopsies from seven patients with neurofibromatosis type 2. In vitro experiments performed on both the P19 neuronal cell line and primary dorsal root ganglion cells demonstrate the influence of merlin on neuregulin 1 type III expression. Moreover, expression of ERBB2, a Schwann cell receptor for neuregulin 1 ligands is increased in nerve tissue of both neuron-specific merlin knockout animals and patients with neurofibromatosis type 2, demonstrating for the first time that axonal merlin indirectly regulates Schwann cell behaviour. Collectively, we have identified that neuronally expressed merlin can influence Schwann cell activity in a cell-extrinsic manner.",
keywords = "Adult, Aged, Animals, Cell Line, Cells, Cultured, Female, Humans, Male, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Middle Aged, Neuregulin-1, Neurofibromatosis 2, Neurofibromin 2, Neurons, Receptor, erbB-2, Schwann Cells, Signal Transduction",
author = "Alexander Schulz and Anna Kyselyova and Baader, {Stephan L} and Jung, {Marie Juliane} and Ansgar Zoch and Victor-Felix Mautner and Christian Hagel and Helen Morrison",
year = "2014",
month = feb,
day = "1",
doi = "10.1093/brain/awt327",
language = "English",
volume = "137",
pages = "420--32",
journal = "BRAIN",
issn = "0006-8950",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Neuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin 1 type III signalling

AU - Schulz, Alexander

AU - Kyselyova, Anna

AU - Baader, Stephan L

AU - Jung, Marie Juliane

AU - Zoch, Ansgar

AU - Mautner, Victor-Felix

AU - Hagel, Christian

AU - Morrison, Helen

PY - 2014/2/1

Y1 - 2014/2/1

N2 - Axonal surface proteins encompass a group of heterogeneous molecules, which exert a variety of different functions in the highly interdependent relationship between axons and Schwann cells. We recently revealed that the tumour suppressor protein merlin, mutated in the hereditary tumour syndrome neurofibromatosis type 2, impacts significantly on axon structure maintenance in the peripheral nervous system. We now report on a role of neuronal merlin in the regulation of the axonal surface protein neuregulin 1 important for modulating Schwann cell differentiation and myelination. Specifically, neuregulin 1 type III expression is reduced in sciatic nerve tissue of neuron-specific knockout animals as well as in biopsies from seven patients with neurofibromatosis type 2. In vitro experiments performed on both the P19 neuronal cell line and primary dorsal root ganglion cells demonstrate the influence of merlin on neuregulin 1 type III expression. Moreover, expression of ERBB2, a Schwann cell receptor for neuregulin 1 ligands is increased in nerve tissue of both neuron-specific merlin knockout animals and patients with neurofibromatosis type 2, demonstrating for the first time that axonal merlin indirectly regulates Schwann cell behaviour. Collectively, we have identified that neuronally expressed merlin can influence Schwann cell activity in a cell-extrinsic manner.

AB - Axonal surface proteins encompass a group of heterogeneous molecules, which exert a variety of different functions in the highly interdependent relationship between axons and Schwann cells. We recently revealed that the tumour suppressor protein merlin, mutated in the hereditary tumour syndrome neurofibromatosis type 2, impacts significantly on axon structure maintenance in the peripheral nervous system. We now report on a role of neuronal merlin in the regulation of the axonal surface protein neuregulin 1 important for modulating Schwann cell differentiation and myelination. Specifically, neuregulin 1 type III expression is reduced in sciatic nerve tissue of neuron-specific knockout animals as well as in biopsies from seven patients with neurofibromatosis type 2. In vitro experiments performed on both the P19 neuronal cell line and primary dorsal root ganglion cells demonstrate the influence of merlin on neuregulin 1 type III expression. Moreover, expression of ERBB2, a Schwann cell receptor for neuregulin 1 ligands is increased in nerve tissue of both neuron-specific merlin knockout animals and patients with neurofibromatosis type 2, demonstrating for the first time that axonal merlin indirectly regulates Schwann cell behaviour. Collectively, we have identified that neuronally expressed merlin can influence Schwann cell activity in a cell-extrinsic manner.

KW - Adult

KW - Aged

KW - Animals

KW - Cell Line

KW - Cells, Cultured

KW - Female

KW - Humans

KW - Male

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Mice, Transgenic

KW - Middle Aged

KW - Neuregulin-1

KW - Neurofibromatosis 2

KW - Neurofibromin 2

KW - Neurons

KW - Receptor, erbB-2

KW - Schwann Cells

KW - Signal Transduction

U2 - 10.1093/brain/awt327

DO - 10.1093/brain/awt327

M3 - SCORING: Journal article

C2 - 24309211

VL - 137

SP - 420

EP - 432

JO - BRAIN

JF - BRAIN

SN - 0006-8950

IS - 2

ER -