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Neurofilaments levels as biomarkers in asymptomatic and symptomatic familial ALS

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Neurofilaments levels as biomarkers in asymptomatic and symptomatic familial ALS. / Weydt, Patrick; Oeckl, Patrick; Huss, André; Müller, Kathrin; Volk, Alexander E; Kuhle, Jens; Knehr, Antje; Andersen, Peter M; Prudlo, Johannes; Steinacker, Petra; Weishaupt, Jochen H; Ludolph, Albert C; Otto, Markus.

in: ANN NEUROL, Jahrgang 79, Nr. 1, 01.2016, S. 152-8.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Weydt, P, Oeckl, P, Huss, A, Müller, K, Volk, AE, Kuhle, J, Knehr, A, Andersen, PM, Prudlo, J, Steinacker, P, Weishaupt, JH, Ludolph, AC & Otto, M 2016, 'Neurofilaments levels as biomarkers in asymptomatic and symptomatic familial ALS', ANN NEUROL, Jg. 79, Nr. 1, S. 152-8. https://doi.org/10.1002/ana.24552

APA

Weydt, P., Oeckl, P., Huss, A., Müller, K., Volk, A. E., Kuhle, J., Knehr, A., Andersen, P. M., Prudlo, J., Steinacker, P., Weishaupt, J. H., Ludolph, A. C., & Otto, M. (2016). Neurofilaments levels as biomarkers in asymptomatic and symptomatic familial ALS. ANN NEUROL, 79(1), 152-8. https://doi.org/10.1002/ana.24552

Vancouver

Weydt P, Oeckl P, Huss A, Müller K, Volk AE, Kuhle J et al. Neurofilaments levels as biomarkers in asymptomatic and symptomatic familial ALS. ANN NEUROL. 2016 Jan;79(1):152-8. https://doi.org/10.1002/ana.24552

Bibtex

@article{504f3ffd0cbe47b89a24fb0cd639959c,
title = "Neurofilaments levels as biomarkers in asymptomatic and symptomatic familial ALS",
abstract = "Neurofilaments are elevated in the cerebrospinal fluid (CSF) and serum of ALS patients. However timing of this increase is unknown. To characterize the premanifest disease phase, we performed a cross-sectional study on asymptomatic (n=12) and symptomatic (n=64) ALS-mutation carriers and family controls (n=19). Neurofilaments NF-L and pNF-H are normal before symptom onset and increased by at least an order of magnitude at early symptom onset in CSF (pNF-H) or serum and CSF (NF-L). Thus blood and CSF neurofilament levels are linked to the symptomatic phase of ALS and might serve as objective markers of structural damage to the nervous system. This article is protected by copyright. All rights reserved.",
author = "Patrick Weydt and Patrick Oeckl and Andr{\'e} Huss and Kathrin M{\"u}ller and Volk, {Alexander E} and Jens Kuhle and Antje Knehr and Andersen, {Peter M} and Johannes Prudlo and Petra Steinacker and Weishaupt, {Jochen H} and Ludolph, {Albert C} and Markus Otto",
note = "{\textcopyright} 2015 American Neurological Association.",
year = "2016",
month = jan,
doi = "10.1002/ana.24552",
language = "English",
volume = "79",
pages = "152--8",
journal = "ANN NEUROL",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Neurofilaments levels as biomarkers in asymptomatic and symptomatic familial ALS

AU - Weydt, Patrick

AU - Oeckl, Patrick

AU - Huss, André

AU - Müller, Kathrin

AU - Volk, Alexander E

AU - Kuhle, Jens

AU - Knehr, Antje

AU - Andersen, Peter M

AU - Prudlo, Johannes

AU - Steinacker, Petra

AU - Weishaupt, Jochen H

AU - Ludolph, Albert C

AU - Otto, Markus

N1 - © 2015 American Neurological Association.

PY - 2016/1

Y1 - 2016/1

N2 - Neurofilaments are elevated in the cerebrospinal fluid (CSF) and serum of ALS patients. However timing of this increase is unknown. To characterize the premanifest disease phase, we performed a cross-sectional study on asymptomatic (n=12) and symptomatic (n=64) ALS-mutation carriers and family controls (n=19). Neurofilaments NF-L and pNF-H are normal before symptom onset and increased by at least an order of magnitude at early symptom onset in CSF (pNF-H) or serum and CSF (NF-L). Thus blood and CSF neurofilament levels are linked to the symptomatic phase of ALS and might serve as objective markers of structural damage to the nervous system. This article is protected by copyright. All rights reserved.

AB - Neurofilaments are elevated in the cerebrospinal fluid (CSF) and serum of ALS patients. However timing of this increase is unknown. To characterize the premanifest disease phase, we performed a cross-sectional study on asymptomatic (n=12) and symptomatic (n=64) ALS-mutation carriers and family controls (n=19). Neurofilaments NF-L and pNF-H are normal before symptom onset and increased by at least an order of magnitude at early symptom onset in CSF (pNF-H) or serum and CSF (NF-L). Thus blood and CSF neurofilament levels are linked to the symptomatic phase of ALS and might serve as objective markers of structural damage to the nervous system. This article is protected by copyright. All rights reserved.

U2 - 10.1002/ana.24552

DO - 10.1002/ana.24552

M3 - SCORING: Journal article

C2 - 26528863

VL - 79

SP - 152

EP - 158

JO - ANN NEUROL

JF - ANN NEUROL

SN - 0364-5134

IS - 1

ER -