Neural correlates of impaired volitional action control in schizophrenia patients
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Neural correlates of impaired volitional action control in schizophrenia patients. / Bender, Julia; Reuter, Benedikt; Möllers, David; Kaufmann, Christian; Gallinat, Jürgen; Kathmann, Norbert.
in: PSYCHOPHYSIOLOGY, Jahrgang 50, Nr. 9, 01.09.2013, S. 872-84.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Neural correlates of impaired volitional action control in schizophrenia patients
AU - Bender, Julia
AU - Reuter, Benedikt
AU - Möllers, David
AU - Kaufmann, Christian
AU - Gallinat, Jürgen
AU - Kathmann, Norbert
N1 - Copyright © 2013 Society for Psychophysiological Research.
PY - 2013/9/1
Y1 - 2013/9/1
N2 - Slowed initiation of volitional but not visually guided saccades indicates impaired volitional action control in schizophrenia patients (SZ). The present study aimed at identifying neural correlates of this specific deficit. Fourteen SZ and 13 healthy control participants (HC) underwent functional magnetic resonance imaging while performing volitional and visually guided saccades. SZ showed increased latencies in volitional but not in visually guided saccades. Brain activation during volitional saccades compared to visually guided saccades was increased in SZ compared to HC in several areas: the supplementary eye fields, suggesting inefficient production of volitional saccades; the prefrontal cortex, pointing to altered top down control on complex eye movements; and the left middle temporal area, suggesting changes in early sensory and attention processing during the volitional control of saccades in SZ.
AB - Slowed initiation of volitional but not visually guided saccades indicates impaired volitional action control in schizophrenia patients (SZ). The present study aimed at identifying neural correlates of this specific deficit. Fourteen SZ and 13 healthy control participants (HC) underwent functional magnetic resonance imaging while performing volitional and visually guided saccades. SZ showed increased latencies in volitional but not in visually guided saccades. Brain activation during volitional saccades compared to visually guided saccades was increased in SZ compared to HC in several areas: the supplementary eye fields, suggesting inefficient production of volitional saccades; the prefrontal cortex, pointing to altered top down control on complex eye movements; and the left middle temporal area, suggesting changes in early sensory and attention processing during the volitional control of saccades in SZ.
KW - Adult
KW - Cerebrum
KW - Cues
KW - Executive Function
KW - Female
KW - Functional Neuroimaging
KW - Humans
KW - Magnetic Resonance Imaging
KW - Male
KW - Middle Aged
KW - Saccades
KW - Schizophrenia
KW - Time Factors
KW - Volition
U2 - 10.1111/psyp.12060
DO - 10.1111/psyp.12060
M3 - SCORING: Journal article
C2 - 23790023
VL - 50
SP - 872
EP - 884
JO - PSYCHOPHYSIOLOGY
JF - PSYCHOPHYSIOLOGY
SN - 0048-5772
IS - 9
ER -