Necrobiosis and T-lymphocyte infiltration in retrieved aseptically loosened metal-on-polyethylene arthroplasties.

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Necrobiosis and T-lymphocyte infiltration in retrieved aseptically loosened metal-on-polyethylene arthroplasties. / von Domarus, Christoph; Rosenberg, Jens P; Rüther, Wolfgang; Zustin, Jozef.

in: ACTA ORTHOP, Jahrgang 82, Nr. 5, 5, 2011, S. 596-601.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsatzForschungBegutachtung

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@article{60aa48c16b0c461ba0d388818a1060f1,
title = "Necrobiosis and T-lymphocyte infiltration in retrieved aseptically loosened metal-on-polyethylene arthroplasties.",
abstract = "Soft tissue necrobiosis and T-lymphocyte infiltration within the periprosthetic soft tissue have been linked to a suggested hypersensitivity reaction of the delayed-type following the metal-on-metal arthroplasty. While we observed both synovial necrobiosis and lymphocyte infiltrates in synovial tissues with failed metal-on-polyethylene prostheses, we hypothesized that both findings are unspecific for metal-on-metal bearing coupes. Thus, we wished to quantify the extent of necrobiosis and the amount of T-lymphocyte infiltration in aseptically loosened metal-on-polyethylene prostheses.",
keywords = "Humans, Aged, Middle Aged, Reoperation, Prosthesis Design, Prosthesis Failure, *Arthroplasty, Replacement, Hip/adverse effects/methods, *Arthroplasty, Replacement, Knee/adverse effects/methods, Biocompatible Materials/adverse effects, Hip Prosthesis/adverse effects, Hypersensitivity/etiology, Knee Prosthesis/adverse effects, Lymphocyte Count, Metals/adverse effects, *Necrobiotic Disorders/chemically induced/immunology/pathology, Polyethylenes/adverse effects, Synovial Membrane/pathology, *T-Lymphocytes/immunology/pathology, Humans, Aged, Middle Aged, Reoperation, Prosthesis Design, Prosthesis Failure, *Arthroplasty, Replacement, Hip/adverse effects/methods, *Arthroplasty, Replacement, Knee/adverse effects/methods, Biocompatible Materials/adverse effects, Hip Prosthesis/adverse effects, Hypersensitivity/etiology, Knee Prosthesis/adverse effects, Lymphocyte Count, Metals/adverse effects, *Necrobiotic Disorders/chemically induced/immunology/pathology, Polyethylenes/adverse effects, Synovial Membrane/pathology, *T-Lymphocytes/immunology/pathology",
author = "{von Domarus}, Christoph and Rosenberg, {Jens P} and Wolfgang R{\"u}ther and Jozef Zustin",
year = "2011",
doi = "10.3109/17453674.2011.625534",
language = "English",
volume = "82",
pages = "596--601",
journal = "ACTA ORTHOP",
issn = "1745-3674",
publisher = "informa healthcare",
number = "5",

}

RIS

TY - JOUR

T1 - Necrobiosis and T-lymphocyte infiltration in retrieved aseptically loosened metal-on-polyethylene arthroplasties.

AU - von Domarus, Christoph

AU - Rosenberg, Jens P

AU - Rüther, Wolfgang

AU - Zustin, Jozef

PY - 2011

Y1 - 2011

N2 - Soft tissue necrobiosis and T-lymphocyte infiltration within the periprosthetic soft tissue have been linked to a suggested hypersensitivity reaction of the delayed-type following the metal-on-metal arthroplasty. While we observed both synovial necrobiosis and lymphocyte infiltrates in synovial tissues with failed metal-on-polyethylene prostheses, we hypothesized that both findings are unspecific for metal-on-metal bearing coupes. Thus, we wished to quantify the extent of necrobiosis and the amount of T-lymphocyte infiltration in aseptically loosened metal-on-polyethylene prostheses.

AB - Soft tissue necrobiosis and T-lymphocyte infiltration within the periprosthetic soft tissue have been linked to a suggested hypersensitivity reaction of the delayed-type following the metal-on-metal arthroplasty. While we observed both synovial necrobiosis and lymphocyte infiltrates in synovial tissues with failed metal-on-polyethylene prostheses, we hypothesized that both findings are unspecific for metal-on-metal bearing coupes. Thus, we wished to quantify the extent of necrobiosis and the amount of T-lymphocyte infiltration in aseptically loosened metal-on-polyethylene prostheses.

KW - Humans

KW - Aged

KW - Middle Aged

KW - Reoperation

KW - Prosthesis Design

KW - Prosthesis Failure

KW - Arthroplasty, Replacement, Hip/adverse effects/methods

KW - Arthroplasty, Replacement, Knee/adverse effects/methods

KW - Biocompatible Materials/adverse effects

KW - Hip Prosthesis/adverse effects

KW - Hypersensitivity/etiology

KW - Knee Prosthesis/adverse effects

KW - Lymphocyte Count

KW - Metals/adverse effects

KW - Necrobiotic Disorders/chemically induced/immunology/pathology

KW - Polyethylenes/adverse effects

KW - Synovial Membrane/pathology

KW - T-Lymphocytes/immunology/pathology

KW - Humans

KW - Aged

KW - Middle Aged

KW - Reoperation

KW - Prosthesis Design

KW - Prosthesis Failure

KW - Arthroplasty, Replacement, Hip/adverse effects/methods

KW - Arthroplasty, Replacement, Knee/adverse effects/methods

KW - Biocompatible Materials/adverse effects

KW - Hip Prosthesis/adverse effects

KW - Hypersensitivity/etiology

KW - Knee Prosthesis/adverse effects

KW - Lymphocyte Count

KW - Metals/adverse effects

KW - Necrobiotic Disorders/chemically induced/immunology/pathology

KW - Polyethylenes/adverse effects

KW - Synovial Membrane/pathology

KW - T-Lymphocytes/immunology/pathology

U2 - 10.3109/17453674.2011.625534

DO - 10.3109/17453674.2011.625534

M3 - SCORING: Journal article

VL - 82

SP - 596

EP - 601

JO - ACTA ORTHOP

JF - ACTA ORTHOP

SN - 1745-3674

IS - 5

M1 - 5

ER -