Nachweis und biologische Bedeutung von Viren und Onkogenen bei Uteruskarzinomen
Standard
Nachweis und biologische Bedeutung von Viren und Onkogenen bei Uteruskarzinomen. / Milde-Langosch, K; Wilckens, C; Brack, T; Löning, T.
in: Verh Dtsch Ges Pathol, Jahrgang 75, 1991, S. 363-365.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Nachweis und biologische Bedeutung von Viren und Onkogenen bei Uteruskarzinomen
AU - Milde-Langosch, K
AU - Wilckens, C
AU - Brack, T
AU - Löning, T
PY - 1991
Y1 - 1991
N2 - Premalignant and malignant lesions of the cervix uteri and endometrium were analyzed for the presence of human papillomavirus (HPV) DNA and c-myc or c-erbB2/neu oncogene expression. HPV DNA was detected by PCR in 100% of the cervical carcinomas and CIN lesions, but also in endometrial lesions (3/8 adenocarcinomas, two hyperplasias and one adenomyosis uteri). Myc-overexpression was found in 25-30% of the cervical carcinomas and severe dysplasias, but not in endometrial lesions. C-erbB2 was overexpressed in 4/11 endometrial carcinomas and 3/19 CIN3 lesions. The implications of these results are discussed.
AB - Premalignant and malignant lesions of the cervix uteri and endometrium were analyzed for the presence of human papillomavirus (HPV) DNA and c-myc or c-erbB2/neu oncogene expression. HPV DNA was detected by PCR in 100% of the cervical carcinomas and CIN lesions, but also in endometrial lesions (3/8 adenocarcinomas, two hyperplasias and one adenomyosis uteri). Myc-overexpression was found in 25-30% of the cervical carcinomas and severe dysplasias, but not in endometrial lesions. C-erbB2 was overexpressed in 4/11 endometrial carcinomas and 3/19 CIN3 lesions. The implications of these results are discussed.
KW - DNA, Viral
KW - Endometrial Neoplasms
KW - Female
KW - Genes, myc
KW - Humans
KW - Oncogenes
KW - Papillomaviridae
KW - Precancerous Conditions
KW - Proto-Oncogene Proteins
KW - Proto-Oncogenes
KW - Receptor, ErbB-2
KW - Tumor Markers, Biological
KW - Uterine Cervical Neoplasms
KW - Uterine Neoplasms
M3 - SCORING: Zeitschriftenaufsatz
C2 - 1724842
VL - 75
SP - 363
EP - 365
ER -