Myocardial tissue Engineering: in vitro models
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Myocardial tissue Engineering: in vitro models. / Vunjak Novakovic, Gordana; Eschenhagen, Thomas; Mummery, Christine.
in: CSH PERSPECT MED, Jahrgang 4, Nr. 3, 01.03.2014.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Myocardial tissue Engineering: in vitro models
AU - Vunjak Novakovic, Gordana
AU - Eschenhagen, Thomas
AU - Mummery, Christine
PY - 2014/3/1
Y1 - 2014/3/1
N2 - Modeling integrated human physiology in vitro is a formidable task not yet achieved with any of the existing cell/tissue systems. However, tissue engineering is becoming increasingly successful at authentic representation of the actual environmental milieu of tissue development, regeneration and disease progression, and in providing real-time insights into morphogenic events. Functional human tissue units engineered to combine biological fidelity with the high-throughput screening and real-time measurement of physiological responses are poised to transform drug screening and predictive modeling of disease. In this review, we focus on the in vitro engineering of functional human myocardium that mimics heart tissue for analysis of myocardial function, in the context of physiological studies, drug screening for therapeutics, and safety pharmacology.
AB - Modeling integrated human physiology in vitro is a formidable task not yet achieved with any of the existing cell/tissue systems. However, tissue engineering is becoming increasingly successful at authentic representation of the actual environmental milieu of tissue development, regeneration and disease progression, and in providing real-time insights into morphogenic events. Functional human tissue units engineered to combine biological fidelity with the high-throughput screening and real-time measurement of physiological responses are poised to transform drug screening and predictive modeling of disease. In this review, we focus on the in vitro engineering of functional human myocardium that mimics heart tissue for analysis of myocardial function, in the context of physiological studies, drug screening for therapeutics, and safety pharmacology.
U2 - 10.1101/cshperspect.a014076
DO - 10.1101/cshperspect.a014076
M3 - SCORING: Journal article
C2 - 24591534
VL - 4
JO - CSH PERSPECT MED
JF - CSH PERSPECT MED
SN - 2157-1422
IS - 3
ER -