Myocardial tissue engineering for cardiac repair
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Myocardial tissue engineering for cardiac repair. / Pecha, Simon; Eschenhagen, Thomas; Reichenspurner, Hermann.
in: J HEART LUNG TRANSPL, Jahrgang 35, Nr. 3, 03.2016, S. 294-298.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Myocardial tissue engineering for cardiac repair
AU - Pecha, Simon
AU - Eschenhagen, Thomas
AU - Reichenspurner, Hermann
N1 - Copyright © 2016 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.
PY - 2016/3
Y1 - 2016/3
N2 - The number of patients with heart failure is increasing in the aging population. Heart transplantation remains the only curative treatment option for patients with end-stage heart failure. Because of an organ donor shortage, new organ-independent treatment options are necessary. Different approaches to cardiac repair therapies have been developed and optimized in recent years. One of these promising approaches is myocardial tissue engineering, which refers to the creation of 3-dimensional engineered heart tissue in vitro. This perspective provides an overview of different approaches to tissue engineering, including essentials to improve tissue quality and choice of ideal cell source, as well as an overview of in vitro and in vivo studies. Several hurdles that have to be overcome before clinical application of engineered heart tissue might become a realistic scenario are also addressed.
AB - The number of patients with heart failure is increasing in the aging population. Heart transplantation remains the only curative treatment option for patients with end-stage heart failure. Because of an organ donor shortage, new organ-independent treatment options are necessary. Different approaches to cardiac repair therapies have been developed and optimized in recent years. One of these promising approaches is myocardial tissue engineering, which refers to the creation of 3-dimensional engineered heart tissue in vitro. This perspective provides an overview of different approaches to tissue engineering, including essentials to improve tissue quality and choice of ideal cell source, as well as an overview of in vitro and in vivo studies. Several hurdles that have to be overcome before clinical application of engineered heart tissue might become a realistic scenario are also addressed.
KW - Editorial
U2 - 10.1016/j.healun.2015.12.007
DO - 10.1016/j.healun.2015.12.007
M3 - SCORING: Journal article
C2 - 26856673
VL - 35
SP - 294
EP - 298
JO - J HEART LUNG TRANSPL
JF - J HEART LUNG TRANSPL
SN - 1053-2498
IS - 3
ER -