Molecular topography of the MED12-deleted region in smooth muscle tumors: a possible link between non-B DNA structures and hypermutability.
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Molecular topography of the MED12-deleted region in smooth muscle tumors: a possible link between non-B DNA structures and hypermutability. / Markowski, Dominique Nadine; Nimzyk, Rolf; Belge, Gazanfer; Löning, Thomas; Helmke, Burkhard Maria; Bullerdiek, Jörn.
in: MOL CYTOGENET, Jahrgang 6, Nr. 1, 1, 2013, S. 23.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Molecular topography of the MED12-deleted region in smooth muscle tumors: a possible link between non-B DNA structures and hypermutability.
AU - Markowski, Dominique Nadine
AU - Nimzyk, Rolf
AU - Belge, Gazanfer
AU - Löning, Thomas
AU - Helmke, Burkhard Maria
AU - Bullerdiek, Jörn
PY - 2013
Y1 - 2013
N2 - Deletions of the gene encoding mediator subcomplex 12 (MED12) in human smooth muscle tumors rank among the most frequent genomic alterations in human tumors at all. In a minority of these cases, small deletions are found. In an attempt to delineate key features of the deletions aimed at a better understanding of the molecular pathogenesis of uterine smooth muscle tumors we have analyzed 70 MED12 deletions including 46 cases from the literature and 24 own unpublished cases.
AB - Deletions of the gene encoding mediator subcomplex 12 (MED12) in human smooth muscle tumors rank among the most frequent genomic alterations in human tumors at all. In a minority of these cases, small deletions are found. In an attempt to delineate key features of the deletions aimed at a better understanding of the molecular pathogenesis of uterine smooth muscle tumors we have analyzed 70 MED12 deletions including 46 cases from the literature and 24 own unpublished cases.
U2 - 10.1186/1755-8166-6-23
DO - 10.1186/1755-8166-6-23
M3 - SCORING: Journal article
VL - 6
SP - 23
JO - MOL CYTOGENET
JF - MOL CYTOGENET
SN - 1755-8166
IS - 1
M1 - 1
ER -