Molecular epidemiology of Mansonella species in Gabon
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Molecular epidemiology of Mansonella species in Gabon. / Sandri, Thaisa Lucas; Kreidenweiss, Andrea; Cavallo, Simon; Weber, David; Juhas, Sascha; Rodi, Miriam; Woldearegai, Tamirat Gebru; Gmeiner, Markus; Veletzky, Luzia; Ramharter, Michael; Tazemda-Kuitsouc, Gildas B; Matsiegui, Pierre Blaise; Mordmüller, Benjamin; Held, Jana.
in: J INFECT DIS, Jahrgang 223, Nr. 2, 03.02.2021, S. 287-296.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Molecular epidemiology of Mansonella species in Gabon
AU - Sandri, Thaisa Lucas
AU - Kreidenweiss, Andrea
AU - Cavallo, Simon
AU - Weber, David
AU - Juhas, Sascha
AU - Rodi, Miriam
AU - Woldearegai, Tamirat Gebru
AU - Gmeiner, Markus
AU - Veletzky, Luzia
AU - Ramharter, Michael
AU - Tazemda-Kuitsouc, Gildas B
AU - Matsiegui, Pierre Blaise
AU - Mordmüller, Benjamin
AU - Held, Jana
N1 - © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
PY - 2021/2/3
Y1 - 2021/2/3
N2 - Mansonella perstans, a filarial nematode, infects large populations in Africa and Latin America. Recently, a potential new species, Mansonella sp "DEUX," was reported. Carriage of endosymbiotic Wolbachia opens treatment options for Mansonella infections. Within a cross-sectional study, we assessed the prevalence of filarial infections in 834 Gabonese individuals and the presence of the endosymbiont Wolbachia. Almost half of the participants (400/834 [48%]) were infected with filarial nematodes, with Mansonella sp "DEUX" being the most frequent (295/400 [74%]), followed by Loa loa (273/400 [68%]) and Mansonella perstans (82/400 [21%]). Being adult/elderly, male, and living in rural areas was associated with a higher risk of infection. Wolbachia carriage was confirmed in M. perstans and Mansonella sp "DEUX." In silico analysis revealed that Mansonella sp "DEUX" is not detected with currently published M. perstans-specific assays. Mansonella infections are highly prevalent in Gabon and might have been underreported, likely also beyond Gabon.
AB - Mansonella perstans, a filarial nematode, infects large populations in Africa and Latin America. Recently, a potential new species, Mansonella sp "DEUX," was reported. Carriage of endosymbiotic Wolbachia opens treatment options for Mansonella infections. Within a cross-sectional study, we assessed the prevalence of filarial infections in 834 Gabonese individuals and the presence of the endosymbiont Wolbachia. Almost half of the participants (400/834 [48%]) were infected with filarial nematodes, with Mansonella sp "DEUX" being the most frequent (295/400 [74%]), followed by Loa loa (273/400 [68%]) and Mansonella perstans (82/400 [21%]). Being adult/elderly, male, and living in rural areas was associated with a higher risk of infection. Wolbachia carriage was confirmed in M. perstans and Mansonella sp "DEUX." In silico analysis revealed that Mansonella sp "DEUX" is not detected with currently published M. perstans-specific assays. Mansonella infections are highly prevalent in Gabon and might have been underreported, likely also beyond Gabon.
U2 - 10.1093/infdis/jiaa670
DO - 10.1093/infdis/jiaa670
M3 - SCORING: Journal article
C2 - 33099649
VL - 223
SP - 287
EP - 296
JO - J INFECT DIS
JF - J INFECT DIS
SN - 0022-1899
IS - 2
ER -