Moderne Diagnostik sexuell übertragbarer Infektionen

TY - JOUR

T1 - Moderne Diagnostik sexuell übertragbarer Infektionen

AU - Brockmeyer, N H

AU - Meyer, Thomas

PY - 2016/1

Y1 - 2016/1

N2 - Diagnosis of sexually transmitted diseases (STD) has significantly improved in recent years by the application of nucleic acid amplification tests (NAAT). In addition to detection of infectious agents, molecular methods were also used for characterization of pathogens (typing, genotypic resistance testing). In contrast to conventional Sanger sequencing of amplicons, new sequencing technologies (next generation sequencing) are able to identify resistant variants that represent only small minorities in a heterogeneous population. NAATs are also available as fully automated closed systems that can be run independently of centralized laboratories and will become increasingly important for point-of-care testing.

AB - Diagnosis of sexually transmitted diseases (STD) has significantly improved in recent years by the application of nucleic acid amplification tests (NAAT). In addition to detection of infectious agents, molecular methods were also used for characterization of pathogens (typing, genotypic resistance testing). In contrast to conventional Sanger sequencing of amplicons, new sequencing technologies (next generation sequencing) are able to identify resistant variants that represent only small minorities in a heterogeneous population. NAATs are also available as fully automated closed systems that can be run independently of centralized laboratories and will become increasingly important for point-of-care testing.

KW - Bacteria

KW - High-Throughput Nucleotide Sequencing

KW - Humans

KW - Point-of-Care Systems

KW - Sexually Transmitted Diseases, Bacterial

KW - Journal Article

KW - Review

U2 - 10.1007/s00105-015-3726-6

DO - 10.1007/s00105-015-3726-6

M3 - SCORING: Zeitschriftenaufsatz

C2 - 26646440

VL - 67

SP - 16

EP - 22

JO - HAUTARZT

JF - HAUTARZT

SN - 0017-8470

IS - 1

ER -