PortalPublikationenMicroRNA-9 controls dendritic development by targeting REST

MicroRNA-9 controls dendritic development by targeting REST

Standard

MicroRNA-9 controls dendritic development by targeting REST. / Giusti, Sebastian A; Vogl, Annette M; Brockmann, Marisa M; Vercelli, Claudia A; Rein, Martin L; Trümbach, Dietrich; Wurst, Wolfgang; Cazalla, Demian; Stein, Valentin; Deussing, Jan M; Refojo, Damian.

in: ELIFE, Jahrgang 3, 18.11.2014.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Giusti, SA, Vogl, AM, Brockmann, MM, Vercelli, CA, Rein, ML, Trümbach, D, Wurst, W, Cazalla, D, Stein, V, Deussing, JM & Refojo, D 2014, 'MicroRNA-9 controls dendritic development by targeting REST', ELIFE, Jg. 3. https://doi.org/10.7554/eLife.02755

APA

Giusti, S. A., Vogl, A. M., Brockmann, M. M., Vercelli, C. A., Rein, M. L., Trümbach, D., Wurst, W., Cazalla, D., Stein, V., Deussing, J. M., & Refojo, D. (2014). MicroRNA-9 controls dendritic development by targeting REST. ELIFE, 3. https://doi.org/10.7554/eLife.02755

Vancouver

Giusti SA, Vogl AM, Brockmann MM, Vercelli CA, Rein ML, Trümbach D et al. MicroRNA-9 controls dendritic development by targeting REST. ELIFE. 2014 Nov 18;3. https://doi.org/10.7554/eLife.02755

Bibtex

@article{6ccf005d7fea455a908ce5e8addf068f,
title = "MicroRNA-9 controls dendritic development by targeting REST",
abstract = "MicroRNAs (miRNAs) are conserved noncoding RNAs that function as posttranscriptional regulators of gene expression. miR-9 is one of the most abundant miRNAs in the brain. Although the function of miR-9 has been well characterized in neural progenitors, its role in dendritic and synaptic development remains largely unknown. In order to target miR-9 in vivo, we developed a transgenic miRNA sponge mouse line allowing conditional inactivation of the miR-9 family in a spatio-temporal-controlled manner. Using this novel approach, we found that miR-9 controls dendritic growth and synaptic transmission in vivo. Furthermore, we demonstrate that miR-9-mediated downregulation of the transcriptional repressor REST is essential for proper dendritic growth. ",
keywords = "Aging/metabolism, Animals, Brain/metabolism, Cells, Cultured, Dendrites/metabolism, Genes, Reporter, HEK293 Cells, Humans, Integrases/metabolism, Mice, Transgenic, MicroRNAs/genetics, Nestin/metabolism, Neurons/metabolism, Repressor Proteins/metabolism, Synaptic Transmission",
author = "Giusti, {Sebastian A} and Vogl, {Annette M} and Brockmann, {Marisa M} and Vercelli, {Claudia A} and Rein, {Martin L} and Dietrich Tr{\"u}mbach and Wolfgang Wurst and Demian Cazalla and Valentin Stein and Deussing, {Jan M} and Damian Refojo",
year = "2014",
month = nov,
day = "18",
doi = "10.7554/eLife.02755",
language = "English",
volume = "3",
journal = "ELIFE",
issn = "2050-084X",
publisher = "eLife Sciences Publications",

}

RIS

TY - JOUR

T1 - MicroRNA-9 controls dendritic development by targeting REST

AU - Giusti, Sebastian A

AU - Vogl, Annette M

AU - Brockmann, Marisa M

AU - Vercelli, Claudia A

AU - Rein, Martin L

AU - Trümbach, Dietrich

AU - Wurst, Wolfgang

AU - Cazalla, Demian

AU - Stein, Valentin

AU - Deussing, Jan M

AU - Refojo, Damian

PY - 2014/11/18

Y1 - 2014/11/18

N2 - MicroRNAs (miRNAs) are conserved noncoding RNAs that function as posttranscriptional regulators of gene expression. miR-9 is one of the most abundant miRNAs in the brain. Although the function of miR-9 has been well characterized in neural progenitors, its role in dendritic and synaptic development remains largely unknown. In order to target miR-9 in vivo, we developed a transgenic miRNA sponge mouse line allowing conditional inactivation of the miR-9 family in a spatio-temporal-controlled manner. Using this novel approach, we found that miR-9 controls dendritic growth and synaptic transmission in vivo. Furthermore, we demonstrate that miR-9-mediated downregulation of the transcriptional repressor REST is essential for proper dendritic growth.

AB - MicroRNAs (miRNAs) are conserved noncoding RNAs that function as posttranscriptional regulators of gene expression. miR-9 is one of the most abundant miRNAs in the brain. Although the function of miR-9 has been well characterized in neural progenitors, its role in dendritic and synaptic development remains largely unknown. In order to target miR-9 in vivo, we developed a transgenic miRNA sponge mouse line allowing conditional inactivation of the miR-9 family in a spatio-temporal-controlled manner. Using this novel approach, we found that miR-9 controls dendritic growth and synaptic transmission in vivo. Furthermore, we demonstrate that miR-9-mediated downregulation of the transcriptional repressor REST is essential for proper dendritic growth.

KW - Aging/metabolism

KW - Animals

KW - Brain/metabolism

KW - Cells, Cultured

KW - Dendrites/metabolism

KW - Genes, Reporter

KW - HEK293 Cells

KW - Humans

KW - Integrases/metabolism

KW - Mice, Transgenic

KW - MicroRNAs/genetics

KW - Nestin/metabolism

KW - Neurons/metabolism

KW - Repressor Proteins/metabolism

KW - Synaptic Transmission

U2 - 10.7554/eLife.02755

DO - 10.7554/eLife.02755

M3 - SCORING: Journal article

C2 - 25406064

VL - 3

JO - ELIFE

JF - ELIFE

SN - 2050-084X

ER -