Methylene Blue (Tetramethylthionine Chloride) Influences the Mobility of Adult Neural Stem Cells

  • Amelie T van der Ven
  • Julius C Pape
  • Dirk Hermann
  • Robert Schloesser
  • Just Genius
  • Nadine Fischer
  • Rainald Mößner
  • Norbert Scherbaum
  • Jens Wiltfang
  • Dan Rujescu
  • Jens Benninghoff

Abstract

An interest in neurogenesis in the adult human brain as a relevant and targetable process has emerged as a potential treatment option for Alzheimer's disease and other neurodegenerative conditions. The aim of this study was to investigate the effects of tetramethylthionine chloride (methylene blue, MB) on properties of adult murine neural stem cells. Based on recent clinical studies, MB has increasingly been discussed as a potential treatment for Alzheimer's disease. While no differences in the proliferative capacity were identified, a general potential of MB in modulating the migratory capacity of adult neural stem cells was indicated in a cell mobility assay. To our knowledge, this is the first time that MB could be associated with neural mobility. The results of this study add insight to the spectrum of features of MB within the central nervous system and may be helpful for understanding the molecular mechanisms underlying a potential therapeutic effect of MB.

Bibliografische Daten

OriginalspracheEnglisch
ISSN1387-2877
DOIs
StatusVeröffentlicht - 2017
Extern publiziertJa
PubMed 28269766