Metformin after bariatric surgery--an acid problem.
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Metformin after bariatric surgery--an acid problem. / Aberle, Jens; Reining, Franziska; Dannheim, Viola; Flitsch, Joerg; Klinge, A; Mann, Oliver.
in: EXP CLIN ENDOCR DIAB, Jahrgang 120, Nr. 3, 3, 2012, S. 152-153.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Metformin after bariatric surgery--an acid problem.
AU - Aberle, Jens
AU - Reining, Franziska
AU - Dannheim, Viola
AU - Flitsch, Joerg
AU - Klinge, A
AU - Mann, Oliver
PY - 2012
Y1 - 2012
N2 - Metformin is the oral drug of first choice in type 2 diabetes. Therefore a large number of patients undergoing bariatric surgery will be on Metformin treatment. However, use of Metformin has been associated with lactate acidosis. Weight loss following bariatric surgery is most pronounced during the first weeks after the operation and this creates a phase of negative energy balance with ketone body formation. To shed more light on this situation we measured ketone bodies in 90 patients 5 days-18 months after bariatric surgery. Ketone bodies were markedly elevated during the first 3-4 months. Metformin use should therefore be critically reconsidered after bariatric operations.
AB - Metformin is the oral drug of first choice in type 2 diabetes. Therefore a large number of patients undergoing bariatric surgery will be on Metformin treatment. However, use of Metformin has been associated with lactate acidosis. Weight loss following bariatric surgery is most pronounced during the first weeks after the operation and this creates a phase of negative energy balance with ketone body formation. To shed more light on this situation we measured ketone bodies in 90 patients 5 days-18 months after bariatric surgery. Ketone bodies were markedly elevated during the first 3-4 months. Metformin use should therefore be critically reconsidered after bariatric operations.
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Practice Guidelines as Topic
KW - Follow-Up Studies
KW - Time Factors
KW - Combined Modality Therapy
KW - Drug Administration Schedule
KW - Acids/blood
KW - Bariatric Surgery/methods/rehabilitation
KW - Diabetes Mellitus, Type 2/blood/complications/drug therapy
KW - Hypoglycemic Agents/administration & dosage
KW - Ketone Bodies/blood
KW - Metformin/administration & dosage
KW - Obesity/blood/complications/drug therapy/surgery
KW - Postoperative Care/methods
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Practice Guidelines as Topic
KW - Follow-Up Studies
KW - Time Factors
KW - Combined Modality Therapy
KW - Drug Administration Schedule
KW - Acids/blood
KW - Bariatric Surgery/methods/rehabilitation
KW - Diabetes Mellitus, Type 2/blood/complications/drug therapy
KW - Hypoglycemic Agents/administration & dosage
KW - Ketone Bodies/blood
KW - Metformin/administration & dosage
KW - Obesity/blood/complications/drug therapy/surgery
KW - Postoperative Care/methods
M3 - SCORING: Journal article
VL - 120
SP - 152
EP - 153
JO - EXP CLIN ENDOCR DIAB
JF - EXP CLIN ENDOCR DIAB
SN - 0947-7349
IS - 3
M1 - 3
ER -