Membrane-anchored peptide inhibits human immunodeficiency virus entry
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Membrane-anchored peptide inhibits human immunodeficiency virus entry. / Hildinger, M; Dittmar, M T; Schult-Dietrich, P; Fehse, B; Schnierle, B S; Thaler, S; Stiegler, G; Welker, R; von Laer, D.
in: J VIROL, Jahrgang 75, Nr. 6, 03.2001, S. 3038-42.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Membrane-anchored peptide inhibits human immunodeficiency virus entry
AU - Hildinger, M
AU - Dittmar, M T
AU - Schult-Dietrich, P
AU - Fehse, B
AU - Schnierle, B S
AU - Thaler, S
AU - Stiegler, G
AU - Welker, R
AU - von Laer, D
PY - 2001/3
Y1 - 2001/3
N2 - Peptides derived from the heptad repeats of human immunodeficiency virus (HIV) gp41 envelope glycoprotein, such as T20, can efficiently inhibit HIV type 1 (HIV-1) entry. In this study, replication of HIV-1 was inhibited more than 100-fold in a T-helper cell line transduced with a retrovirus vector expressing membrane-anchored T20 on the cell surface. Inhibition was independent of coreceptor usage.
AB - Peptides derived from the heptad repeats of human immunodeficiency virus (HIV) gp41 envelope glycoprotein, such as T20, can efficiently inhibit HIV type 1 (HIV-1) entry. In this study, replication of HIV-1 was inhibited more than 100-fold in a T-helper cell line transduced with a retrovirus vector expressing membrane-anchored T20 on the cell surface. Inhibition was independent of coreceptor usage.
KW - Amino Acid Sequence
KW - Cell Line
KW - Cell Membrane/metabolism
KW - Enfuvirtide
KW - Genetic Vectors
KW - HIV Envelope Protein gp41/chemistry
KW - HIV-1/physiology
KW - Humans
KW - Molecular Sequence Data
KW - Peptide Fragments/chemistry
KW - Retroviridae/genetics
KW - T-Lymphocytes, Helper-Inducer/virology
KW - Transduction, Genetic
KW - Virus Replication
U2 - 10.1128/JVI.75.6.3038-3042.2001
DO - 10.1128/JVI.75.6.3038-3042.2001
M3 - SCORING: Journal article
C2 - 11222732
VL - 75
SP - 3038
EP - 3042
JO - J VIROL
JF - J VIROL
SN - 0022-538X
IS - 6
ER -