PortalPublikationenMembrane-anchored peptide inhibits human immunodeficiency vi...

Membrane-anchored peptide inhibits human immunodeficiency virus entry

  • M Hildinger
  • M T Dittmar
  • P Schult-Dietrich
  • B Fehse
  • B S Schnierle
  • S Thaler
  • G Stiegler
  • R Welker
  • D von Laer

Beteiligte Einrichtungen

Abstract

Peptides derived from the heptad repeats of human immunodeficiency virus (HIV) gp41 envelope glycoprotein, such as T20, can efficiently inhibit HIV type 1 (HIV-1) entry. In this study, replication of HIV-1 was inhibited more than 100-fold in a T-helper cell line transduced with a retrovirus vector expressing membrane-anchored T20 on the cell surface. Inhibition was independent of coreceptor usage.

Bibliografische Daten

OriginalspracheEnglisch
ISSN0022-538X
DOIs
StatusVeröffentlicht - 03.2001
PubMed 11222732