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Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells

Standard

Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. / Yang, Zeng-Jie; Ellis, Tammy; Markant, Shirley L; Read, Tracy-Ann; Kessler, Jessica D; Bourboulas, Melissa; Schüller, Ulrich; Machold, Robert; Fishell, Gord; Rowitch, David H; Wainwright, Brandon J; Wechsler-Reya, Robert J.

in: CANCER CELL, Jahrgang 14, Nr. 2, 12.08.2008, S. 135-45.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Yang, Z-J, Ellis, T, Markant, SL, Read, T-A, Kessler, JD, Bourboulas, M, Schüller, U, Machold, R, Fishell, G, Rowitch, DH, Wainwright, BJ & Wechsler-Reya, RJ 2008, 'Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells', CANCER CELL, Jg. 14, Nr. 2, S. 135-45. https://doi.org/10.1016/j.ccr.2008.07.003

APA

Yang, Z-J., Ellis, T., Markant, S. L., Read, T-A., Kessler, J. D., Bourboulas, M., Schüller, U., Machold, R., Fishell, G., Rowitch, D. H., Wainwright, B. J., & Wechsler-Reya, R. J. (2008). Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. CANCER CELL, 14(2), 135-45. https://doi.org/10.1016/j.ccr.2008.07.003

Vancouver

Yang Z-J, Ellis T, Markant SL, Read T-A, Kessler JD, Bourboulas M et al. Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells. CANCER CELL. 2008 Aug 12;14(2):135-45. https://doi.org/10.1016/j.ccr.2008.07.003

Bibtex

@article{013b4fb0843f4629a13433148498d8b4,
title = "Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells",
abstract = "Medulloblastoma is the most common malignant brain tumor in children, but the cells from which it arises remain unclear. Here we examine the origin of medulloblastoma resulting from mutations in the Sonic hedgehog (Shh) pathway. We show that activation of Shh signaling in neuronal progenitors causes medulloblastoma by 3 months of age. Shh pathway activation in stem cells promotes stem cell proliferation but only causes tumors after commitment to-and expansion of-the neuronal lineage. Notably, tumors initiated in stem cells develop more rapidly than those initiated in progenitors, with all animals succumbing by 3-4 weeks. These studies suggest that medulloblastoma can be initiated in progenitors or stem cells but that Shh-induced tumorigenesis is associated with neuronal lineage commitment.",
keywords = "Animals, Basic Helix-Loop-Helix Transcription Factors, Cell Differentiation, Cell Lineage, Cell Proliferation, Gene Deletion, Glial Fibrillary Acidic Protein, Hedgehog Proteins, Humans, Hyperplasia, Integrases, Medulloblastoma, Mice, Mice, Knockout, Neurons, Patched Receptors, Phenotype, Precancerous Conditions, Receptors, Cell Surface, Stem Cells, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't",
author = "Zeng-Jie Yang and Tammy Ellis and Markant, {Shirley L} and Tracy-Ann Read and Kessler, {Jessica D} and Melissa Bourboulas and Ulrich Sch{\"u}ller and Robert Machold and Gord Fishell and Rowitch, {David H} and Wainwright, {Brandon J} and Wechsler-Reya, {Robert J}",
year = "2008",
month = aug,
day = "12",
doi = "10.1016/j.ccr.2008.07.003",
language = "English",
volume = "14",
pages = "135--45",
journal = "CANCER CELL",
issn = "1535-6108",
publisher = "Cell Press",
number = "2",

}

RIS

TY - JOUR

T1 - Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells

AU - Yang, Zeng-Jie

AU - Ellis, Tammy

AU - Markant, Shirley L

AU - Read, Tracy-Ann

AU - Kessler, Jessica D

AU - Bourboulas, Melissa

AU - Schüller, Ulrich

AU - Machold, Robert

AU - Fishell, Gord

AU - Rowitch, David H

AU - Wainwright, Brandon J

AU - Wechsler-Reya, Robert J

PY - 2008/8/12

Y1 - 2008/8/12

N2 - Medulloblastoma is the most common malignant brain tumor in children, but the cells from which it arises remain unclear. Here we examine the origin of medulloblastoma resulting from mutations in the Sonic hedgehog (Shh) pathway. We show that activation of Shh signaling in neuronal progenitors causes medulloblastoma by 3 months of age. Shh pathway activation in stem cells promotes stem cell proliferation but only causes tumors after commitment to-and expansion of-the neuronal lineage. Notably, tumors initiated in stem cells develop more rapidly than those initiated in progenitors, with all animals succumbing by 3-4 weeks. These studies suggest that medulloblastoma can be initiated in progenitors or stem cells but that Shh-induced tumorigenesis is associated with neuronal lineage commitment.

AB - Medulloblastoma is the most common malignant brain tumor in children, but the cells from which it arises remain unclear. Here we examine the origin of medulloblastoma resulting from mutations in the Sonic hedgehog (Shh) pathway. We show that activation of Shh signaling in neuronal progenitors causes medulloblastoma by 3 months of age. Shh pathway activation in stem cells promotes stem cell proliferation but only causes tumors after commitment to-and expansion of-the neuronal lineage. Notably, tumors initiated in stem cells develop more rapidly than those initiated in progenitors, with all animals succumbing by 3-4 weeks. These studies suggest that medulloblastoma can be initiated in progenitors or stem cells but that Shh-induced tumorigenesis is associated with neuronal lineage commitment.

KW - Animals

KW - Basic Helix-Loop-Helix Transcription Factors

KW - Cell Differentiation

KW - Cell Lineage

KW - Cell Proliferation

KW - Gene Deletion

KW - Glial Fibrillary Acidic Protein

KW - Hedgehog Proteins

KW - Humans

KW - Hyperplasia

KW - Integrases

KW - Medulloblastoma

KW - Mice

KW - Mice, Knockout

KW - Neurons

KW - Patched Receptors

KW - Phenotype

KW - Precancerous Conditions

KW - Receptors, Cell Surface

KW - Stem Cells

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.ccr.2008.07.003

DO - 10.1016/j.ccr.2008.07.003

M3 - SCORING: Journal article

C2 - 18691548

VL - 14

SP - 135

EP - 145

JO - CANCER CELL

JF - CANCER CELL

SN - 1535-6108

IS - 2

ER -