Medawar's PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune Adaptation

Ellen Menkhorst; Nandor Gabor Than; Udo Jeschke; Gabriela Barrientos; Laszlo Szereday; Gabriela Dveksler; Sandra M Blois

doi:10.3389/fimmu.2021.784473

Medawar's PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune Adaptation

Standard

Medawar's PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune Adaptation. / Menkhorst, Ellen; Than, Nandor Gabor; Jeschke, Udo; Barrientos, Gabriela; Szereday, Laszlo; Dveksler, Gabriela; Blois, Sandra M.

in: FRONT IMMUNOL, Jahrgang 12, 784473, 2021.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Menkhorst, E, Than, NG, Jeschke, U, Barrientos, G, Szereday, L, Dveksler, G & Blois, SM 2021, 'Medawar's PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune Adaptation', FRONT IMMUNOL, Jg. 12, 784473. https://doi.org/10.3389/fimmu.2021.784473

APA

Menkhorst, E., Than, N. G., Jeschke, U., Barrientos, G., Szereday, L., Dveksler, G., & Blois, S. M. (2021). Medawar's PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune Adaptation. FRONT IMMUNOL, 12, [784473]. https://doi.org/10.3389/fimmu.2021.784473

Vancouver

Menkhorst E, Than NG, Jeschke U, Barrientos G, Szereday L, Dveksler G et al. Medawar's PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune Adaptation. FRONT IMMUNOL. 2021;12. 784473. https://doi.org/10.3389/fimmu.2021.784473

Bibtex

@article{f5fb0dd86b4749309fb36fad3fd965da,

title = "Medawar's PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune Adaptation",

abstract = "Lectin-glycan interactions, in particular those mediated by the galectin family, regulate many processes required for a successful pregnancy. Over the past decades, increasing evidence gathered from in vitro and in vivo experiments indicate that members of the galectin family specifically bind to both intracellular and membrane bound carbohydrate ligands regulating angiogenesis, immune-cell adaptations required to tolerate the fetal semi-allograft and mammalian embryogenesis. Therefore, galectins play important roles in fetal development and placentation contributing to maternal and fetal health. This review discusses the expression and role of galectins during the course of pregnancy, with an emphasis on maternal immune adaptions and galectin-glycan interactions uncovered in the recent years. In addition, we summarize the galectin fingerprints associated with pathological gestation with particular focus on preeclampsia.",

author = "Ellen Menkhorst and Than, {Nandor Gabor} and Udo Jeschke and Gabriela Barrientos and Laszlo Szereday and Gabriela Dveksler and Blois, {Sandra M}",

note = "Copyright {\textcopyright} 2021 Menkhorst, Than, Jeschke, Barrientos, Szereday, Dveksler and Blois.",

year = "2021",

doi = "10.3389/fimmu.2021.784473",

language = "English",

volume = "12",

journal = "FRONT IMMUNOL",

issn = "1664-3224",

publisher = "Lausanne : Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Medawar's PostEra: Galectins Emerged as Key Players During Fetal-Maternal Glycoimmune Adaptation

AU - Menkhorst, Ellen

AU - Than, Nandor Gabor

AU - Jeschke, Udo

AU - Barrientos, Gabriela

AU - Szereday, Laszlo

AU - Dveksler, Gabriela

AU - Blois, Sandra M

PY - 2021

Y1 - 2021

N2 - Lectin-glycan interactions, in particular those mediated by the galectin family, regulate many processes required for a successful pregnancy. Over the past decades, increasing evidence gathered from in vitro and in vivo experiments indicate that members of the galectin family specifically bind to both intracellular and membrane bound carbohydrate ligands regulating angiogenesis, immune-cell adaptations required to tolerate the fetal semi-allograft and mammalian embryogenesis. Therefore, galectins play important roles in fetal development and placentation contributing to maternal and fetal health. This review discusses the expression and role of galectins during the course of pregnancy, with an emphasis on maternal immune adaptions and galectin-glycan interactions uncovered in the recent years. In addition, we summarize the galectin fingerprints associated with pathological gestation with particular focus on preeclampsia.

AB - Lectin-glycan interactions, in particular those mediated by the galectin family, regulate many processes required for a successful pregnancy. Over the past decades, increasing evidence gathered from in vitro and in vivo experiments indicate that members of the galectin family specifically bind to both intracellular and membrane bound carbohydrate ligands regulating angiogenesis, immune-cell adaptations required to tolerate the fetal semi-allograft and mammalian embryogenesis. Therefore, galectins play important roles in fetal development and placentation contributing to maternal and fetal health. This review discusses the expression and role of galectins during the course of pregnancy, with an emphasis on maternal immune adaptions and galectin-glycan interactions uncovered in the recent years. In addition, we summarize the galectin fingerprints associated with pathological gestation with particular focus on preeclampsia.

U2 - 10.3389/fimmu.2021.784473

DO - 10.3389/fimmu.2021.784473

M3 - SCORING: Review article

C2 - 34975875

VL - 12

JO - FRONT IMMUNOL

JF - FRONT IMMUNOL

SN - 1664-3224

M1 - 784473

ER -