mecA is not involved in the sigmaB-dependent switch of the expression phenotype of methicillin resistance in Staphylococcus epidermidis
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mecA is not involved in the sigmaB-dependent switch of the expression phenotype of methicillin resistance in Staphylococcus epidermidis. / Knobloch, Johannes K-M; Jäger, Sebastian; Huck, Jörn; Horstkotte, Matthias A; Mack, Dietrich.
in: ANTIMICROB AGENTS CH, Jahrgang 49, Nr. 3, 03.2005, S. 1216-9.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - mecA is not involved in the sigmaB-dependent switch of the expression phenotype of methicillin resistance in Staphylococcus epidermidis
AU - Knobloch, Johannes K-M
AU - Jäger, Sebastian
AU - Huck, Jörn
AU - Horstkotte, Matthias A
AU - Mack, Dietrich
PY - 2005/3
Y1 - 2005/3
N2 - A lack of sigma(B) activity reduces methicillin resistance in heterogeneous Staphylococcus epidermidis 1057, whereas inactivation of the anti-sigma factor RsbW switched the phenotype to homogeneous expression of resistance. Oxacillin induction of mecA transcription is reduced in a sigma(B)-negative strain. However, mecA is not involved in the switch of expression phenotype.
AB - A lack of sigma(B) activity reduces methicillin resistance in heterogeneous Staphylococcus epidermidis 1057, whereas inactivation of the anti-sigma factor RsbW switched the phenotype to homogeneous expression of resistance. Oxacillin induction of mecA transcription is reduced in a sigma(B)-negative strain. However, mecA is not involved in the switch of expression phenotype.
KW - Bacterial Proteins/genetics
KW - Methicillin Resistance
KW - Oxacillin/pharmacology
KW - Phenotype
KW - Reverse Transcriptase Polymerase Chain Reaction
KW - Sigma Factor/physiology
KW - Staphylococcus epidermidis/drug effects
KW - Transcription, Genetic
U2 - 10.1128/AAC.49.3.1216-1219.2005
DO - 10.1128/AAC.49.3.1216-1219.2005
M3 - SCORING: Journal article
C2 - 15728932
VL - 49
SP - 1216
EP - 1219
JO - ANTIMICROB AGENTS CH
JF - ANTIMICROB AGENTS CH
SN - 0066-4804
IS - 3
ER -