Maternal interpersonal affiliation is associated with adolescents' brain structure and reward processing.
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Maternal interpersonal affiliation is associated with adolescents' brain structure and reward processing. / Schneider, Sophia; Brassen, Stefanie; Bromberg, Uli; Banaschewski, T; Conrod, P; Flor, H; Gallinat, J; Garavan, Hugh; Heinz, A; Martinot, J-L; Nees, F; Rietschel, M; Smolka, M N; Ströhle, A; Struve, M; Schumann, G; Büchel, Christian; Consortium, IMAGEN.
in: TRANSL PSYCHIAT, Jahrgang 2, 2012, S. 182.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Maternal interpersonal affiliation is associated with adolescents' brain structure and reward processing.
AU - Schneider, Sophia
AU - Brassen, Stefanie
AU - Bromberg, Uli
AU - Banaschewski, T
AU - Conrod, P
AU - Flor, H
AU - Gallinat, J
AU - Garavan, Hugh
AU - Heinz, A
AU - Martinot, J-L
AU - Nees, F
AU - Rietschel, M
AU - Smolka, M N
AU - Ströhle, A
AU - Struve, M
AU - Schumann, G
AU - Büchel, Christian
AU - Consortium, IMAGEN
PY - 2012
Y1 - 2012
N2 - Considerable animal and human research has been dedicated to the effects of parenting on structural brain development, focusing on hippocampal and prefrontal areas. Conversely, although functional imaging studies suggest that the neural reward circuitry is involved in parental affection, little is known about mothers' interpersonal qualities in relation to their children's brain structure and function. Moreover, gender differences concerning the effect of maternal qualities have rarely been investigated systematically. In 63 adolescents, we assessed structural and functional magnetic resonance imaging as well as interpersonal affiliation in their mothers. This allowed us to associate maternal affiliation with gray matter density and neural responses during different phases of the well-established Monetary Incentive Delay task. Maternal affiliation was positively associated with hippocampal and orbitofrontal gray matter density. Moreover, in the feedback of reward hit as compared with reward miss, an association with caudate activation was found. Although no significant gender effects were observed in these associations, during reward feedback as compared with baseline, maternal affiliation was significantly associated with ventral striatal and caudate activation only in females. Our findings demonstrate that maternal interpersonal affiliation is related to alterations in both the brain structure and reward-related activation in healthy adolescents. Importantly, the pattern is in line with typical findings in depression and post-traumatic stress disorder, suggesting that a lack of maternal affiliation might have a role in the genesis of mental disorders.
AB - Considerable animal and human research has been dedicated to the effects of parenting on structural brain development, focusing on hippocampal and prefrontal areas. Conversely, although functional imaging studies suggest that the neural reward circuitry is involved in parental affection, little is known about mothers' interpersonal qualities in relation to their children's brain structure and function. Moreover, gender differences concerning the effect of maternal qualities have rarely been investigated systematically. In 63 adolescents, we assessed structural and functional magnetic resonance imaging as well as interpersonal affiliation in their mothers. This allowed us to associate maternal affiliation with gray matter density and neural responses during different phases of the well-established Monetary Incentive Delay task. Maternal affiliation was positively associated with hippocampal and orbitofrontal gray matter density. Moreover, in the feedback of reward hit as compared with reward miss, an association with caudate activation was found. Although no significant gender effects were observed in these associations, during reward feedback as compared with baseline, maternal affiliation was significantly associated with ventral striatal and caudate activation only in females. Our findings demonstrate that maternal interpersonal affiliation is related to alterations in both the brain structure and reward-related activation in healthy adolescents. Importantly, the pattern is in line with typical findings in depression and post-traumatic stress disorder, suggesting that a lack of maternal affiliation might have a role in the genesis of mental disorders.
KW - Humans
KW - Male
KW - Female
KW - Adolescent
KW - Magnetic Resonance Imaging
KW - Organ Size
KW - Functional Neuroimaging
KW - Reward
KW - Brain/anatomy & histology/physiology
KW - Caudate Nucleus/anatomy & histology/physiology
KW - Hippocampus/anatomy & histology/physiology
KW - Mother-Child Relations
KW - Nerve Fibers, Unmyelinated/physiology
KW - Prefrontal Cortex/anatomy & histology/physiology
KW - Humans
KW - Male
KW - Female
KW - Adolescent
KW - Magnetic Resonance Imaging
KW - Organ Size
KW - Functional Neuroimaging
KW - Reward
KW - Brain/anatomy & histology/physiology
KW - Caudate Nucleus/anatomy & histology/physiology
KW - Hippocampus/anatomy & histology/physiology
KW - Mother-Child Relations
KW - Nerve Fibers, Unmyelinated/physiology
KW - Prefrontal Cortex/anatomy & histology/physiology
U2 - 10.1038/tp.2012.113
DO - 10.1038/tp.2012.113
M3 - SCORING: Journal article
VL - 2
SP - 182
JO - TRANSL PSYCHIAT
JF - TRANSL PSYCHIAT
SN - 2158-3188
ER -
