PortalPublikationenMannose 6 phosphorylation of lysosomal enzymes controls B ce...

Mannose 6 phosphorylation of lysosomal enzymes controls B cell functions

Standard

Mannose 6 phosphorylation of lysosomal enzymes controls B cell functions. / Otomo, Takanobu; Schweizer, Michaela; Kollmann, Katrin; Schumacher, Valéa; Muschol, Nicole; Tolosa, Eva; Mittrücker, Hans-Willi; Braulke, Thomas.

in: J CELL BIOL, Jahrgang 208, Nr. 2, 19.01.2015, S. 171-80.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Otomo, T, Schweizer, M, Kollmann, K, Schumacher, V, Muschol, N, Tolosa, E, Mittrücker, H-W & Braulke, T 2015, 'Mannose 6 phosphorylation of lysosomal enzymes controls B cell functions', J CELL BIOL, Jg. 208, Nr. 2, S. 171-80. https://doi.org/10.1083/jcb.201407077

APA

Otomo, T., Schweizer, M., Kollmann, K., Schumacher, V., Muschol, N., Tolosa, E., Mittrücker, H-W., & Braulke, T. (2015). Mannose 6 phosphorylation of lysosomal enzymes controls B cell functions. J CELL BIOL, 208(2), 171-80. https://doi.org/10.1083/jcb.201407077

Vancouver

Otomo T, Schweizer M, Kollmann K, Schumacher V, Muschol N, Tolosa E et al. Mannose 6 phosphorylation of lysosomal enzymes controls B cell functions. J CELL BIOL. 2015 Jan 19;208(2):171-80. https://doi.org/10.1083/jcb.201407077

Bibtex

@article{f43fb6fb6bdf47479e713457bd69ccea,
title = "Mannose 6 phosphorylation of lysosomal enzymes controls B cell functions",
abstract = "Antigen processing and presentation and cytotoxic targeting depend on the activities of several lysosomal enzymes that require mannose 6-phosphate (M6P) sorting signals for efficient intracellular transport and localization. In this paper, we show that mice deficient in the formation of M6P residues exhibit significant loss of cathepsin proteases in B cells, leading to lysosomal dysfunction with accumulation of storage material, impaired antigen processing and presentation, and subsequent defects in B cell maturation and antibody production. The targeting of lysosomal and granular enzymes lacking M6P residues is less affected in dendritic cells and T cells and sufficient for maintenance of degradative and lytic functions. M6P deficiency also impairs serum immunoglobulin levels and antibody responses to vaccination in patients. Our data demonstrate the critical role of M6P-dependent transport routes for B cell functions in vivo and humoral immunity in mice and human.",
author = "Takanobu Otomo and Michaela Schweizer and Katrin Kollmann and Val{\'e}a Schumacher and Nicole Muschol and Eva Tolosa and Hans-Willi Mittr{\"u}cker and Thomas Braulke",
note = "{\textcopyright} 2015 Otomo et al.",
year = "2015",
month = jan,
day = "19",
doi = "10.1083/jcb.201407077",
language = "English",
volume = "208",
pages = "171--80",
journal = "J CELL BIOL",
issn = "0021-9525",
publisher = "Rockefeller University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Mannose 6 phosphorylation of lysosomal enzymes controls B cell functions

AU - Otomo, Takanobu

AU - Schweizer, Michaela

AU - Kollmann, Katrin

AU - Schumacher, Valéa

AU - Muschol, Nicole

AU - Tolosa, Eva

AU - Mittrücker, Hans-Willi

AU - Braulke, Thomas

N1 - © 2015 Otomo et al.

PY - 2015/1/19

Y1 - 2015/1/19

N2 - Antigen processing and presentation and cytotoxic targeting depend on the activities of several lysosomal enzymes that require mannose 6-phosphate (M6P) sorting signals for efficient intracellular transport and localization. In this paper, we show that mice deficient in the formation of M6P residues exhibit significant loss of cathepsin proteases in B cells, leading to lysosomal dysfunction with accumulation of storage material, impaired antigen processing and presentation, and subsequent defects in B cell maturation and antibody production. The targeting of lysosomal and granular enzymes lacking M6P residues is less affected in dendritic cells and T cells and sufficient for maintenance of degradative and lytic functions. M6P deficiency also impairs serum immunoglobulin levels and antibody responses to vaccination in patients. Our data demonstrate the critical role of M6P-dependent transport routes for B cell functions in vivo and humoral immunity in mice and human.

AB - Antigen processing and presentation and cytotoxic targeting depend on the activities of several lysosomal enzymes that require mannose 6-phosphate (M6P) sorting signals for efficient intracellular transport and localization. In this paper, we show that mice deficient in the formation of M6P residues exhibit significant loss of cathepsin proteases in B cells, leading to lysosomal dysfunction with accumulation of storage material, impaired antigen processing and presentation, and subsequent defects in B cell maturation and antibody production. The targeting of lysosomal and granular enzymes lacking M6P residues is less affected in dendritic cells and T cells and sufficient for maintenance of degradative and lytic functions. M6P deficiency also impairs serum immunoglobulin levels and antibody responses to vaccination in patients. Our data demonstrate the critical role of M6P-dependent transport routes for B cell functions in vivo and humoral immunity in mice and human.

U2 - 10.1083/jcb.201407077

DO - 10.1083/jcb.201407077

M3 - SCORING: Journal article

C2 - 25601403

VL - 208

SP - 171

EP - 180

JO - J CELL BIOL

JF - J CELL BIOL

SN - 0021-9525

IS - 2

ER -