Mandibular condyle morphology among patients with mucopolysaccharidosis: an observational study of panoramic radiographs
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Mandibular condyle morphology among patients with mucopolysaccharidosis: an observational study of panoramic radiographs. / Schmid-Herrmann, Carmen Ulrike; Muschol, Nicole; Fuhrmann, Vera; Koehn, Anja Friederike; Lezius, Susanne; Kahl-Nieke, Bärbel; Koehne, Till.
in: INT J PAEDIATR DENT, Jahrgang 32, Nr. 5, 09.2022, S. 737-744.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Mandibular condyle morphology among patients with mucopolysaccharidosis: an observational study of panoramic radiographs
AU - Schmid-Herrmann, Carmen Ulrike
AU - Muschol, Nicole
AU - Fuhrmann, Vera
AU - Koehn, Anja Friederike
AU - Lezius, Susanne
AU - Kahl-Nieke, Bärbel
AU - Koehne, Till
N1 - This article is protected by copyright. All rights reserved.
PY - 2022/9
Y1 - 2022/9
N2 - BACKGROUND: Mucopolysaccharidoses (MPS) are a group of rare metabolic diseases characterized by a wide spectrum of symptoms including progressive condylar resorption.AIM: The aim of this study was to quantify the severity of condylar involvement in MPS I individuals in comparison with a group of non-MPS individuals and to describe how condylar changes may vary among the different types of MPS.DESIGN: Fifty panoramic radiographs of MPS patients (13.4 ± 6.2 years) with MPS I (n = 14), MPS II (n = 2), MPS IV (n = 8) and MPS VI (n = 2) were compared with forty panoramic radiographs of non-MPS individuals. The severity of condylar resorption was evaluated using a qualitative score (grades 0-3) and using the ratio of condylar height to ramus height (CH: RH).RESULTS: All MPS I and VI individuals showed pronounced bilateral degenerative condylar resorption. In contrast, individuals with MPS II and IV exhibited heterogeneous findings. The quantification of condylar height to ramus height revealed that CH: RH was significantly decreased in MPS I as compared to that of non-MPS individuals (P < .001). In contrast, the CH: RH ratios of MPS II and IV showed great variability.CONCLUSION: Mucopolysaccharidoses subtypes differ with regard to the severity of condylar resorption.
AB - BACKGROUND: Mucopolysaccharidoses (MPS) are a group of rare metabolic diseases characterized by a wide spectrum of symptoms including progressive condylar resorption.AIM: The aim of this study was to quantify the severity of condylar involvement in MPS I individuals in comparison with a group of non-MPS individuals and to describe how condylar changes may vary among the different types of MPS.DESIGN: Fifty panoramic radiographs of MPS patients (13.4 ± 6.2 years) with MPS I (n = 14), MPS II (n = 2), MPS IV (n = 8) and MPS VI (n = 2) were compared with forty panoramic radiographs of non-MPS individuals. The severity of condylar resorption was evaluated using a qualitative score (grades 0-3) and using the ratio of condylar height to ramus height (CH: RH).RESULTS: All MPS I and VI individuals showed pronounced bilateral degenerative condylar resorption. In contrast, individuals with MPS II and IV exhibited heterogeneous findings. The quantification of condylar height to ramus height revealed that CH: RH was significantly decreased in MPS I as compared to that of non-MPS individuals (P < .001). In contrast, the CH: RH ratios of MPS II and IV showed great variability.CONCLUSION: Mucopolysaccharidoses subtypes differ with regard to the severity of condylar resorption.
U2 - 10.1111/ipd.12952
DO - 10.1111/ipd.12952
M3 - SCORING: Journal article
C2 - 34967064
VL - 32
SP - 737
EP - 744
JO - INT J PAEDIATR DENT
JF - INT J PAEDIATR DENT
SN - 0960-7439
IS - 5
ER -
