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Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation

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Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation. / Fischer, Alexander W; Jaeckstein, Michelle Y; Gottschling, Kristina; Heine, Markus; Sass, Frederike; Mangels, Nils; Schlein, Christian; Worthmann, Anna; Bruns, Oliver T; Yuan, Yucheng; Zhu, Hua; Chen, Ou; Ittrich, Harald; Nilsson, Stefan K; Stefanicka, Patrik; Ukropec, Jozef; Balaz, Miroslav; Dong, Hua; Sun, Wenfei; Reimer, Rudolf; Scheja, Ludger; Heeren, Joerg.

in: CELL METAB, Jahrgang 33, Nr. 3, 02.03.2021, S. 547-564.e7.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Fischer, AW, Jaeckstein, MY, Gottschling, K, Heine, M, Sass, F, Mangels, N, Schlein, C, Worthmann, A, Bruns, OT, Yuan, Y, Zhu, H, Chen, O, Ittrich, H, Nilsson, SK, Stefanicka, P, Ukropec, J, Balaz, M, Dong, H, Sun, W, Reimer, R, Scheja, L & Heeren, J 2021, 'Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation', CELL METAB, Jg. 33, Nr. 3, S. 547-564.e7. https://doi.org/10.1016/j.cmet.2020.12.001

APA

Fischer, A. W., Jaeckstein, M. Y., Gottschling, K., Heine, M., Sass, F., Mangels, N., Schlein, C., Worthmann, A., Bruns, O. T., Yuan, Y., Zhu, H., Chen, O., Ittrich, H., Nilsson, S. K., Stefanicka, P., Ukropec, J., Balaz, M., Dong, H., Sun, W., ... Heeren, J. (2021). Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation. CELL METAB, 33(3), 547-564.e7. https://doi.org/10.1016/j.cmet.2020.12.001

Vancouver

Fischer AW, Jaeckstein MY, Gottschling K, Heine M, Sass F, Mangels N et al. Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation. CELL METAB. 2021 Mär 2;33(3):547-564.e7. https://doi.org/10.1016/j.cmet.2020.12.001

Bibtex

@article{b08693b0b7534f3fa3951dad36a43e56,
title = "Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation",
abstract = "In response to cold exposure, thermogenic adipocytes internalize large amounts of fatty acids after lipoprotein lipase-mediated hydrolysis of triglyceride-rich lipoproteins (TRL) in the capillary lumen of brown adipose tissue (BAT) and white adipose tissue (WAT). Here, we show that in cold-exposed mice, vascular endothelial cells in adipose tissues endocytose substantial amounts of entire TRL particles. These lipoproteins subsequently follow the endosomal-lysosomal pathway, where they undergo lysosomal acid lipase (LAL)-mediated processing. Endothelial cell-specific LAL deficiency results in impaired thermogenic capacity as a consequence of reduced recruitment of brown and brite/beige adipocytes. Mechanistically, TRL processing by LAL induces proliferation of endothelial cells and adipocyte precursors via beta-oxidation-dependent production of reactive oxygen species, which in turn stimulates hypoxia-inducible factor-1α-dependent proliferative responses. In conclusion, this study demonstrates a physiological role for TRL particle uptake into BAT and WAT and establishes endothelial lipoprotein processing as an important determinant of adipose tissue remodeling during thermogenic adaptation.",
author = "Fischer, {Alexander W} and Jaeckstein, {Michelle Y} and Kristina Gottschling and Markus Heine and Frederike Sass and Nils Mangels and Christian Schlein and Anna Worthmann and Bruns, {Oliver T} and Yucheng Yuan and Hua Zhu and Ou Chen and Harald Ittrich and Nilsson, {Stefan K} and Patrik Stefanicka and Jozef Ukropec and Miroslav Balaz and Hua Dong and Wenfei Sun and Rudolf Reimer and Ludger Scheja and Joerg Heeren",
note = "Copyright {\textcopyright} 2020 Elsevier Inc. All rights reserved.",
year = "2021",
month = mar,
day = "2",
doi = "10.1016/j.cmet.2020.12.001",
language = "English",
volume = "33",
pages = "547--564.e7",
journal = "CELL METAB",
issn = "1550-4131",
publisher = "Cell Press",
number = "3",

}

RIS

TY - JOUR

T1 - Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation

AU - Fischer, Alexander W

AU - Jaeckstein, Michelle Y

AU - Gottschling, Kristina

AU - Heine, Markus

AU - Sass, Frederike

AU - Mangels, Nils

AU - Schlein, Christian

AU - Worthmann, Anna

AU - Bruns, Oliver T

AU - Yuan, Yucheng

AU - Zhu, Hua

AU - Chen, Ou

AU - Ittrich, Harald

AU - Nilsson, Stefan K

AU - Stefanicka, Patrik

AU - Ukropec, Jozef

AU - Balaz, Miroslav

AU - Dong, Hua

AU - Sun, Wenfei

AU - Reimer, Rudolf

AU - Scheja, Ludger

AU - Heeren, Joerg

N1 - Copyright © 2020 Elsevier Inc. All rights reserved.

PY - 2021/3/2

Y1 - 2021/3/2

N2 - In response to cold exposure, thermogenic adipocytes internalize large amounts of fatty acids after lipoprotein lipase-mediated hydrolysis of triglyceride-rich lipoproteins (TRL) in the capillary lumen of brown adipose tissue (BAT) and white adipose tissue (WAT). Here, we show that in cold-exposed mice, vascular endothelial cells in adipose tissues endocytose substantial amounts of entire TRL particles. These lipoproteins subsequently follow the endosomal-lysosomal pathway, where they undergo lysosomal acid lipase (LAL)-mediated processing. Endothelial cell-specific LAL deficiency results in impaired thermogenic capacity as a consequence of reduced recruitment of brown and brite/beige adipocytes. Mechanistically, TRL processing by LAL induces proliferation of endothelial cells and adipocyte precursors via beta-oxidation-dependent production of reactive oxygen species, which in turn stimulates hypoxia-inducible factor-1α-dependent proliferative responses. In conclusion, this study demonstrates a physiological role for TRL particle uptake into BAT and WAT and establishes endothelial lipoprotein processing as an important determinant of adipose tissue remodeling during thermogenic adaptation.

AB - In response to cold exposure, thermogenic adipocytes internalize large amounts of fatty acids after lipoprotein lipase-mediated hydrolysis of triglyceride-rich lipoproteins (TRL) in the capillary lumen of brown adipose tissue (BAT) and white adipose tissue (WAT). Here, we show that in cold-exposed mice, vascular endothelial cells in adipose tissues endocytose substantial amounts of entire TRL particles. These lipoproteins subsequently follow the endosomal-lysosomal pathway, where they undergo lysosomal acid lipase (LAL)-mediated processing. Endothelial cell-specific LAL deficiency results in impaired thermogenic capacity as a consequence of reduced recruitment of brown and brite/beige adipocytes. Mechanistically, TRL processing by LAL induces proliferation of endothelial cells and adipocyte precursors via beta-oxidation-dependent production of reactive oxygen species, which in turn stimulates hypoxia-inducible factor-1α-dependent proliferative responses. In conclusion, this study demonstrates a physiological role for TRL particle uptake into BAT and WAT and establishes endothelial lipoprotein processing as an important determinant of adipose tissue remodeling during thermogenic adaptation.

U2 - 10.1016/j.cmet.2020.12.001

DO - 10.1016/j.cmet.2020.12.001

M3 - SCORING: Journal article

C2 - 33357458

VL - 33

SP - 547-564.e7

JO - CELL METAB

JF - CELL METAB

SN - 1550-4131

IS - 3

ER -