Lynx web services for annotations and systems analysis of multi-gene disorders
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Lynx web services for annotations and systems analysis of multi-gene disorders. / Sulakhe, Dinanath; Taylor, Andrew; Balasubramanian, Sandhya; Feng, Bo; Xie, Bingqing; Börnigen, Daniela; Dave, Utpal J; Foster, Ian T; Gilliam, T Conrad; Maltsev, Natalia.
in: NUCLEIC ACIDS RES, Jahrgang 42, Nr. Web Server issue, 07.2014, S. W473-477.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Lynx web services for annotations and systems analysis of multi-gene disorders
AU - Sulakhe, Dinanath
AU - Taylor, Andrew
AU - Balasubramanian, Sandhya
AU - Feng, Bo
AU - Xie, Bingqing
AU - Börnigen, Daniela
AU - Dave, Utpal J
AU - Foster, Ian T
AU - Gilliam, T Conrad
AU - Maltsev, Natalia
N1 - © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.
PY - 2014/7
Y1 - 2014/7
N2 - Lynx is a web-based integrated systems biology platform that supports annotation and analysis of experimental data and generation of weighted hypotheses on molecular mechanisms contributing to human phenotypes and disorders of interest. Lynx has integrated multiple classes of biomedical data (genomic, proteomic, pathways, phenotypic, toxicogenomic, contextual and others) from various public databases as well as manually curated data from our group and collaborators (LynxKB). Lynx provides tools for gene list enrichment analysis using multiple functional annotations and network-based gene prioritization. Lynx provides access to the integrated database and the analytical tools via REST based Web Services (http://lynx.ci.uchicago.edu/webservices.html). This comprises data retrieval services for specific functional annotations, services to search across the complete LynxKB (powered by Lucene), and services to access the analytical tools built within the Lynx platform.
AB - Lynx is a web-based integrated systems biology platform that supports annotation and analysis of experimental data and generation of weighted hypotheses on molecular mechanisms contributing to human phenotypes and disorders of interest. Lynx has integrated multiple classes of biomedical data (genomic, proteomic, pathways, phenotypic, toxicogenomic, contextual and others) from various public databases as well as manually curated data from our group and collaborators (LynxKB). Lynx provides tools for gene list enrichment analysis using multiple functional annotations and network-based gene prioritization. Lynx provides access to the integrated database and the analytical tools via REST based Web Services (http://lynx.ci.uchicago.edu/webservices.html). This comprises data retrieval services for specific functional annotations, services to search across the complete LynxKB (powered by Lucene), and services to access the analytical tools built within the Lynx platform.
KW - Databases, Factual
KW - Genes
KW - Genetic Diseases, Inborn
KW - Humans
KW - Internet
KW - Knowledge Bases
KW - Software
KW - Systems Biology
KW - Journal Article
KW - Research Support, N.I.H., Extramural
KW - Research Support, Non-U.S. Gov't
U2 - 10.1093/nar/gku517
DO - 10.1093/nar/gku517
M3 - SCORING: Journal article
C2 - 24948611
VL - 42
SP - W473-477
JO - NUCLEIC ACIDS RES
JF - NUCLEIC ACIDS RES
SN - 0305-1048
IS - Web Server issue
ER -