Long-term survival of an infant with an atypical teratoid/rhabdoid tumor following subtotal resection and low-cumulative dose chemotherapy: a case report
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Long-term survival of an infant with an atypical teratoid/rhabdoid tumor following subtotal resection and low-cumulative dose chemotherapy: a case report. / Arnhold, Viktor; Oyen, Florian; Schneppenheim, Reinhard; Haberl, Hannes; Koch, Arend; Frühwald, Michael C; Hernáiz Driever, Pablo.
in: CHILD NERV SYST, Jahrgang 32, Nr. 6, 08.01.2016, S. 1157-61.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Long-term survival of an infant with an atypical teratoid/rhabdoid tumor following subtotal resection and low-cumulative dose chemotherapy: a case report
AU - Arnhold, Viktor
AU - Oyen, Florian
AU - Schneppenheim, Reinhard
AU - Haberl, Hannes
AU - Koch, Arend
AU - Frühwald, Michael C
AU - Hernáiz Driever, Pablo
PY - 2016/1/8
Y1 - 2016/1/8
N2 - INTRODUCTION: Atypical teratoid/rhabdoid tumor (AT/RT) is an aggressive embryonal tumor of the central nervous system with a generally dismal prognosis, especially in patients younger than 12 months.DISCUSSION: We here describe the unusual case of an infant with AT/RT with long-term survival despite low-cumulative dose chemotherapy after subtotal resection. Due to a poor neurological situation and an unfavorable oncological prognosis, therapy was halted after two partial surgical resections and four of the nine chemotherapy courses recommended by the European Rhabdoid Registry, without the patient receiving either radiotherapy or high-dose chemotherapy. The patient is alive without evidence of disease 52 months after diagnosis.CONCLUSION: This case report highlights that independent prognostic factors are urgently needed for optimizing treatment stratification and preventing overtreatment.
AB - INTRODUCTION: Atypical teratoid/rhabdoid tumor (AT/RT) is an aggressive embryonal tumor of the central nervous system with a generally dismal prognosis, especially in patients younger than 12 months.DISCUSSION: We here describe the unusual case of an infant with AT/RT with long-term survival despite low-cumulative dose chemotherapy after subtotal resection. Due to a poor neurological situation and an unfavorable oncological prognosis, therapy was halted after two partial surgical resections and four of the nine chemotherapy courses recommended by the European Rhabdoid Registry, without the patient receiving either radiotherapy or high-dose chemotherapy. The patient is alive without evidence of disease 52 months after diagnosis.CONCLUSION: This case report highlights that independent prognostic factors are urgently needed for optimizing treatment stratification and preventing overtreatment.
U2 - 10.1007/s00381-015-2999-5
DO - 10.1007/s00381-015-2999-5
M3 - SCORING: Journal article
C2 - 26747622
VL - 32
SP - 1157
EP - 1161
JO - CHILD NERV SYST
JF - CHILD NERV SYST
SN - 0256-7040
IS - 6
ER -