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Liver fibrosis in recessive multicystic kidney diseases: transient elastography for early detection.

Standard

Liver fibrosis in recessive multicystic kidney diseases: transient elastography for early detection. / Kummer, Sebastian; Sagir, Abdurrahman; Pandey, Simone; Feldkötter, Markus; Habbig, Sandra; Körber, Friederike; Ney, Dietrich; Hoppe, Bernd; Häussinger, Dieter; Mayatepek, Ertan; Oh, Jun.

in: PEDIATR NEPHROL, Jahrgang 26, Nr. 5, 5, 05.2011, S. 725-731.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kummer, S, Sagir, A, Pandey, S, Feldkötter, M, Habbig, S, Körber, F, Ney, D, Hoppe, B, Häussinger, D, Mayatepek, E & Oh, J 2011, 'Liver fibrosis in recessive multicystic kidney diseases: transient elastography for early detection.', PEDIATR NEPHROL, Jg. 26, Nr. 5, 5, S. 725-731. https://doi.org/10.1007/s00467-011-1771-7

APA

Kummer, S., Sagir, A., Pandey, S., Feldkötter, M., Habbig, S., Körber, F., Ney, D., Hoppe, B., Häussinger, D., Mayatepek, E., & Oh, J. (2011). Liver fibrosis in recessive multicystic kidney diseases: transient elastography for early detection. PEDIATR NEPHROL, 26(5), 725-731. [5]. https://doi.org/10.1007/s00467-011-1771-7

Vancouver

Kummer S, Sagir A, Pandey S, Feldkötter M, Habbig S, Körber F et al. Liver fibrosis in recessive multicystic kidney diseases: transient elastography for early detection. PEDIATR NEPHROL. 2011 Mai;26(5):725-731. 5. https://doi.org/10.1007/s00467-011-1771-7

Bibtex

@article{a83f0e5badf9467ba54813dcb7a12b0a,
title = "Liver fibrosis in recessive multicystic kidney diseases: transient elastography for early detection.",
abstract = "Cystic renal diseases are characterized by intrarenal cysts of different size and number. Further important diagnostic criteria include, e.g., liver fibrosis. The latter represents a significant cause of morbidity and mortality in autosomal-recessive polycystic kidney disease (ARPKD), whereas patients with autosomal-dominant polycystic kidney disease (ADPKD) can develop hepatic cysts without fibrosis. We report the use of transient elastography [FibroScan{\textregistered}, (FS)] for early and noninvasive detection of increased liver stiffness as marker of liver fibrosis. Compared with matched healthy controls, ADPKD patients (n = 7) showed no significant difference in liver stiffness (5.3 kPa vs. 4.5 kPa; ns). ARPKD patients (n = 7) had significantly increased median liver stiffness compared with controls (12.0 kPa vs. 4.5 kPa, p = 0.002) and ADPKD patients (12.0 kPa vs. 5.3 kPa, p = 0.002). Conventional ultrasound revealed evidence of liver fibrosis in only four of seven ARPKD patients (57%) compared with 100% detection by FS. Additional laboratory examinations showed no pathologic liver parameters. In conclusion, our data found FS to be a valuable, sensitive, and noninvasive new tool for early evaluation of liver fibrosis in cystic kidney diseases. This could facilitate diagnosis, monitoring, and management of liver involvement in ARPKD or any other cystic kidney disease.",
keywords = "Humans, Male, Female, Adolescent, Young Adult, Child, Child, Preschool, Infant, Early Diagnosis, Elasticity Imaging Techniques/*methods, Liver Cirrhosis/*ultrasonography, Polycystic Kidney Diseases/*ultrasonography, Humans, Male, Female, Adolescent, Young Adult, Child, Child, Preschool, Infant, Early Diagnosis, Elasticity Imaging Techniques/*methods, Liver Cirrhosis/*ultrasonography, Polycystic Kidney Diseases/*ultrasonography",
author = "Sebastian Kummer and Abdurrahman Sagir and Simone Pandey and Markus Feldk{\"o}tter and Sandra Habbig and Friederike K{\"o}rber and Dietrich Ney and Bernd Hoppe and Dieter H{\"a}ussinger and Ertan Mayatepek and Jun Oh",
year = "2011",
month = may,
doi = "10.1007/s00467-011-1771-7",
language = "English",
volume = "26",
pages = "725--731",
journal = "PEDIATR NEPHROL",
issn = "0931-041X",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Liver fibrosis in recessive multicystic kidney diseases: transient elastography for early detection.

AU - Kummer, Sebastian

AU - Sagir, Abdurrahman

AU - Pandey, Simone

AU - Feldkötter, Markus

AU - Habbig, Sandra

AU - Körber, Friederike

AU - Ney, Dietrich

AU - Hoppe, Bernd

AU - Häussinger, Dieter

AU - Mayatepek, Ertan

AU - Oh, Jun

PY - 2011/5

Y1 - 2011/5

N2 - Cystic renal diseases are characterized by intrarenal cysts of different size and number. Further important diagnostic criteria include, e.g., liver fibrosis. The latter represents a significant cause of morbidity and mortality in autosomal-recessive polycystic kidney disease (ARPKD), whereas patients with autosomal-dominant polycystic kidney disease (ADPKD) can develop hepatic cysts without fibrosis. We report the use of transient elastography [FibroScan®, (FS)] for early and noninvasive detection of increased liver stiffness as marker of liver fibrosis. Compared with matched healthy controls, ADPKD patients (n = 7) showed no significant difference in liver stiffness (5.3 kPa vs. 4.5 kPa; ns). ARPKD patients (n = 7) had significantly increased median liver stiffness compared with controls (12.0 kPa vs. 4.5 kPa, p = 0.002) and ADPKD patients (12.0 kPa vs. 5.3 kPa, p = 0.002). Conventional ultrasound revealed evidence of liver fibrosis in only four of seven ARPKD patients (57%) compared with 100% detection by FS. Additional laboratory examinations showed no pathologic liver parameters. In conclusion, our data found FS to be a valuable, sensitive, and noninvasive new tool for early evaluation of liver fibrosis in cystic kidney diseases. This could facilitate diagnosis, monitoring, and management of liver involvement in ARPKD or any other cystic kidney disease.

AB - Cystic renal diseases are characterized by intrarenal cysts of different size and number. Further important diagnostic criteria include, e.g., liver fibrosis. The latter represents a significant cause of morbidity and mortality in autosomal-recessive polycystic kidney disease (ARPKD), whereas patients with autosomal-dominant polycystic kidney disease (ADPKD) can develop hepatic cysts without fibrosis. We report the use of transient elastography [FibroScan®, (FS)] for early and noninvasive detection of increased liver stiffness as marker of liver fibrosis. Compared with matched healthy controls, ADPKD patients (n = 7) showed no significant difference in liver stiffness (5.3 kPa vs. 4.5 kPa; ns). ARPKD patients (n = 7) had significantly increased median liver stiffness compared with controls (12.0 kPa vs. 4.5 kPa, p = 0.002) and ADPKD patients (12.0 kPa vs. 5.3 kPa, p = 0.002). Conventional ultrasound revealed evidence of liver fibrosis in only four of seven ARPKD patients (57%) compared with 100% detection by FS. Additional laboratory examinations showed no pathologic liver parameters. In conclusion, our data found FS to be a valuable, sensitive, and noninvasive new tool for early evaluation of liver fibrosis in cystic kidney diseases. This could facilitate diagnosis, monitoring, and management of liver involvement in ARPKD or any other cystic kidney disease.

KW - Humans

KW - Male

KW - Female

KW - Adolescent

KW - Young Adult

KW - Child

KW - Child, Preschool

KW - Infant

KW - Early Diagnosis

KW - Elasticity Imaging Techniques/methods

KW - Liver Cirrhosis/ultrasonography

KW - Polycystic Kidney Diseases/ultrasonography

KW - Humans

KW - Male

KW - Female

KW - Adolescent

KW - Young Adult

KW - Child

KW - Child, Preschool

KW - Infant

KW - Early Diagnosis

KW - Elasticity Imaging Techniques/methods

KW - Liver Cirrhosis/ultrasonography

KW - Polycystic Kidney Diseases/ultrasonography

U2 - 10.1007/s00467-011-1771-7

DO - 10.1007/s00467-011-1771-7

M3 - SCORING: Journal article

C2 - 21279811

VL - 26

SP - 725

EP - 731

JO - PEDIATR NEPHROL

JF - PEDIATR NEPHROL

SN - 0931-041X

IS - 5

M1 - 5

ER -