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Late recurrence of a pineal germinoma 14 years after radiation and chemotherapy: a case report and review of the literature

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Late recurrence of a pineal germinoma 14 years after radiation and chemotherapy: a case report and review of the literature. / Janjetovic, Snjezana; Bokemeyer, Carsten; Fiedler, Walter; Frenzel, Thorsten; Calaminus, Gabriele; Honecker, Friedemann.

in: ONKOLOGIE, Jahrgang 36, Nr. 6, 01.01.2013, S. 371-3.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Janjetovic, S, Bokemeyer, C, Fiedler, W, Frenzel, T, Calaminus, G & Honecker, F 2013, 'Late recurrence of a pineal germinoma 14 years after radiation and chemotherapy: a case report and review of the literature', ONKOLOGIE, Jg. 36, Nr. 6, S. 371-3. https://doi.org/10.1159/000351255

APA

Janjetovic, S., Bokemeyer, C., Fiedler, W., Frenzel, T., Calaminus, G., & Honecker, F. (2013). Late recurrence of a pineal germinoma 14 years after radiation and chemotherapy: a case report and review of the literature. ONKOLOGIE, 36(6), 371-3. https://doi.org/10.1159/000351255

Vancouver

Janjetovic S, Bokemeyer C, Fiedler W, Frenzel T, Calaminus G, Honecker F. Late recurrence of a pineal germinoma 14 years after radiation and chemotherapy: a case report and review of the literature. ONKOLOGIE. 2013 Jan 1;36(6):371-3. https://doi.org/10.1159/000351255

Bibtex

@article{f8b8fd1eebf74fa1b08ebb04be5f7035,
title = "Late recurrence of a pineal germinoma 14 years after radiation and chemotherapy: a case report and review of the literature",
abstract = "BACKGROUND: Intracranial germinomas (IG) are rare and highly curable tumors. The incidence and optimal treatment of recurrences are not well defined.CASE REPORT: A 34-year-old male was diagnosed with a late recurrence of an IG 14 years after the initial diagnosis and treatment. The diagnosis was complicated by the absence of tumor markers and delayed histological sampling of the lesion. Upon histological confirmation, the patient received 2 cycles of conventional chemotherapy, followed by 2 cycles of highdose chemotherapy and peripheral blood stem cell transplantation. The patient achieved a complete remission on magnetic resonance imaging scan. Consolidating radiation of the involved field was performed after termination of the chemotherapy. Conclusion: Limited information on the optimal management of late relapses of IG call for individualized therapeutic approaches. Platinum-based chemotherapy, followed by high-dose chemotherapy and consolidative radiation, appears to be feasible and effective in this situation.",
keywords = "Adult, Antineoplastic Agents, Brain Neoplasms, Chemoradiotherapy, Combined Modality Therapy, Germinoma, Humans, Male, Neoplasm Recurrence, Local, Peripheral Blood Stem Cell Transplantation, Pineal Gland, Pinealoma, Radiotherapy, Conformal, Treatment Outcome",
author = "Snjezana Janjetovic and Carsten Bokemeyer and Walter Fiedler and Thorsten Frenzel and Gabriele Calaminus and Friedemann Honecker",
note = "{\textcopyright} 2013 S. Karger GmbH, Freiburg.",
year = "2013",
month = jan,
day = "1",
doi = "10.1159/000351255",
language = "English",
volume = "36",
pages = "371--3",
journal = "ONKOLOGIE",
issn = "0378-584X",
publisher = "S. Karger AG",
number = "6",

}

RIS

TY - JOUR

T1 - Late recurrence of a pineal germinoma 14 years after radiation and chemotherapy: a case report and review of the literature

AU - Janjetovic, Snjezana

AU - Bokemeyer, Carsten

AU - Fiedler, Walter

AU - Frenzel, Thorsten

AU - Calaminus, Gabriele

AU - Honecker, Friedemann

N1 - © 2013 S. Karger GmbH, Freiburg.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - BACKGROUND: Intracranial germinomas (IG) are rare and highly curable tumors. The incidence and optimal treatment of recurrences are not well defined.CASE REPORT: A 34-year-old male was diagnosed with a late recurrence of an IG 14 years after the initial diagnosis and treatment. The diagnosis was complicated by the absence of tumor markers and delayed histological sampling of the lesion. Upon histological confirmation, the patient received 2 cycles of conventional chemotherapy, followed by 2 cycles of highdose chemotherapy and peripheral blood stem cell transplantation. The patient achieved a complete remission on magnetic resonance imaging scan. Consolidating radiation of the involved field was performed after termination of the chemotherapy. Conclusion: Limited information on the optimal management of late relapses of IG call for individualized therapeutic approaches. Platinum-based chemotherapy, followed by high-dose chemotherapy and consolidative radiation, appears to be feasible and effective in this situation.

AB - BACKGROUND: Intracranial germinomas (IG) are rare and highly curable tumors. The incidence and optimal treatment of recurrences are not well defined.CASE REPORT: A 34-year-old male was diagnosed with a late recurrence of an IG 14 years after the initial diagnosis and treatment. The diagnosis was complicated by the absence of tumor markers and delayed histological sampling of the lesion. Upon histological confirmation, the patient received 2 cycles of conventional chemotherapy, followed by 2 cycles of highdose chemotherapy and peripheral blood stem cell transplantation. The patient achieved a complete remission on magnetic resonance imaging scan. Consolidating radiation of the involved field was performed after termination of the chemotherapy. Conclusion: Limited information on the optimal management of late relapses of IG call for individualized therapeutic approaches. Platinum-based chemotherapy, followed by high-dose chemotherapy and consolidative radiation, appears to be feasible and effective in this situation.

KW - Adult

KW - Antineoplastic Agents

KW - Brain Neoplasms

KW - Chemoradiotherapy

KW - Combined Modality Therapy

KW - Germinoma

KW - Humans

KW - Male

KW - Neoplasm Recurrence, Local

KW - Peripheral Blood Stem Cell Transplantation

KW - Pineal Gland

KW - Pinealoma

KW - Radiotherapy, Conformal

KW - Treatment Outcome

U2 - 10.1159/000351255

DO - 10.1159/000351255

M3 - SCORING: Journal article

C2 - 23774153

VL - 36

SP - 371

EP - 373

JO - ONKOLOGIE

JF - ONKOLOGIE

SN - 0378-584X

IS - 6

ER -