Late recurrence of a pineal germinoma 14 years after radiation and chemotherapy: a case report and review of the literature
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Late recurrence of a pineal germinoma 14 years after radiation and chemotherapy: a case report and review of the literature. / Janjetovic, Snjezana; Bokemeyer, Carsten; Fiedler, Walter; Frenzel, Thorsten; Calaminus, Gabriele; Honecker, Friedemann.
In: ONKOLOGIE, Vol. 36, No. 6, 01.01.2013, p. 371-3.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Late recurrence of a pineal germinoma 14 years after radiation and chemotherapy: a case report and review of the literature
AU - Janjetovic, Snjezana
AU - Bokemeyer, Carsten
AU - Fiedler, Walter
AU - Frenzel, Thorsten
AU - Calaminus, Gabriele
AU - Honecker, Friedemann
N1 - © 2013 S. Karger GmbH, Freiburg.
PY - 2013/1/1
Y1 - 2013/1/1
N2 - BACKGROUND: Intracranial germinomas (IG) are rare and highly curable tumors. The incidence and optimal treatment of recurrences are not well defined.CASE REPORT: A 34-year-old male was diagnosed with a late recurrence of an IG 14 years after the initial diagnosis and treatment. The diagnosis was complicated by the absence of tumor markers and delayed histological sampling of the lesion. Upon histological confirmation, the patient received 2 cycles of conventional chemotherapy, followed by 2 cycles of highdose chemotherapy and peripheral blood stem cell transplantation. The patient achieved a complete remission on magnetic resonance imaging scan. Consolidating radiation of the involved field was performed after termination of the chemotherapy. Conclusion: Limited information on the optimal management of late relapses of IG call for individualized therapeutic approaches. Platinum-based chemotherapy, followed by high-dose chemotherapy and consolidative radiation, appears to be feasible and effective in this situation.
AB - BACKGROUND: Intracranial germinomas (IG) are rare and highly curable tumors. The incidence and optimal treatment of recurrences are not well defined.CASE REPORT: A 34-year-old male was diagnosed with a late recurrence of an IG 14 years after the initial diagnosis and treatment. The diagnosis was complicated by the absence of tumor markers and delayed histological sampling of the lesion. Upon histological confirmation, the patient received 2 cycles of conventional chemotherapy, followed by 2 cycles of highdose chemotherapy and peripheral blood stem cell transplantation. The patient achieved a complete remission on magnetic resonance imaging scan. Consolidating radiation of the involved field was performed after termination of the chemotherapy. Conclusion: Limited information on the optimal management of late relapses of IG call for individualized therapeutic approaches. Platinum-based chemotherapy, followed by high-dose chemotherapy and consolidative radiation, appears to be feasible and effective in this situation.
KW - Adult
KW - Antineoplastic Agents
KW - Brain Neoplasms
KW - Chemoradiotherapy
KW - Combined Modality Therapy
KW - Germinoma
KW - Humans
KW - Male
KW - Neoplasm Recurrence, Local
KW - Peripheral Blood Stem Cell Transplantation
KW - Pineal Gland
KW - Pinealoma
KW - Radiotherapy, Conformal
KW - Treatment Outcome
U2 - 10.1159/000351255
DO - 10.1159/000351255
M3 - SCORING: Journal article
C2 - 23774153
VL - 36
SP - 371
EP - 373
JO - ONKOLOGIE
JF - ONKOLOGIE
SN - 0378-584X
IS - 6
ER -