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Is there any relationship between gene expression of tumor antigens and CD4+ T cells in multiple myeloma?

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Is there any relationship between gene expression of tumor antigens and CD4+ T cells in multiple myeloma? / Braga, Walter Mt; da Silva, Bruna R; Alves, Veruska Lf; Bortoluzo, Adriana B; Atanackovic, Djordje; Colleoni, Gisele Wb.

in: IMMUNOTHERAPY-UK, Jahrgang 6, Nr. 5, 2014, S. 569-75.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Braga, WM, da Silva, BR, Alves, VL, Bortoluzo, AB, Atanackovic, D & Colleoni, GW 2014, 'Is there any relationship between gene expression of tumor antigens and CD4+ T cells in multiple myeloma?', IMMUNOTHERAPY-UK, Jg. 6, Nr. 5, S. 569-75. https://doi.org/10.2217/imt.14.24

APA

Braga, W. M., da Silva, B. R., Alves, V. L., Bortoluzo, A. B., Atanackovic, D., & Colleoni, G. W. (2014). Is there any relationship between gene expression of tumor antigens and CD4+ T cells in multiple myeloma? IMMUNOTHERAPY-UK, 6(5), 569-75. https://doi.org/10.2217/imt.14.24

Vancouver

Braga WM, da Silva BR, Alves VL, Bortoluzo AB, Atanackovic D, Colleoni GW. Is there any relationship between gene expression of tumor antigens and CD4+ T cells in multiple myeloma? IMMUNOTHERAPY-UK. 2014;6(5):569-75. https://doi.org/10.2217/imt.14.24

Bibtex

@article{f623299e6ad549afa27428045bd80537,
title = "Is there any relationship between gene expression of tumor antigens and CD4+ T cells in multiple myeloma?",
abstract = "AIM: The present study aimed at correlating the expression of cancer/testis antigens (CTAs) with the expression of genes related to tumor-infiltrating T cells.MATERIALS & METHODS: MAGE-C1/CT-7, MAGEA3/6, NY-ESO-1, LAGE-1 and GAGE expression were evaluated in 46 bone marrow multiple myeloma (MM) aspirates by RT-PCR. Expression of FOXP3/CTLA4 and RORyt, as markers for Tregs and Th17 cells, respectively, was investigated by quantitative PCR.RESULTS: MAGEC1/CT7 was expressed in 66% of MM samples. We did not find correlation between the presence of single CTA and expression of CTLA4 or RORyt neither expression of CD4(+) T-cell markers and the number of CTA simultaneously expressed in the tumor. However, we did observe a correlation between the percentage of plasma cells and the number of CTAs expressed in the patients' bone marrow.CONCLUSION: Although CTAs and immunomodulatory CD4(+) T cells represent potential targets for immunotherapy in MM, we did not find association among expression of such genes in MM.",
keywords = "Adult, Aged, Aged, 80 and over, Antigens, Neoplasm, Bone Marrow, CD4-Positive T-Lymphocytes, Female, Gene Expression Regulation, Neoplastic, Humans, Male, Middle Aged, Multiple Myeloma, Neoplasm Proteins, Plasma Cells, Tumor Markers, Biological",
author = "Braga, {Walter Mt} and {da Silva}, {Bruna R} and Alves, {Veruska Lf} and Bortoluzo, {Adriana B} and Djordje Atanackovic and Colleoni, {Gisele Wb}",
year = "2014",
doi = "10.2217/imt.14.24",
language = "English",
volume = "6",
pages = "569--75",
journal = "IMMUNOTHERAPY-UK",
issn = "1750-743X",
publisher = "Future Medicine Ltd",
number = "5",

}

RIS

TY - JOUR

T1 - Is there any relationship between gene expression of tumor antigens and CD4+ T cells in multiple myeloma?

AU - Braga, Walter Mt

AU - da Silva, Bruna R

AU - Alves, Veruska Lf

AU - Bortoluzo, Adriana B

AU - Atanackovic, Djordje

AU - Colleoni, Gisele Wb

PY - 2014

Y1 - 2014

N2 - AIM: The present study aimed at correlating the expression of cancer/testis antigens (CTAs) with the expression of genes related to tumor-infiltrating T cells.MATERIALS & METHODS: MAGE-C1/CT-7, MAGEA3/6, NY-ESO-1, LAGE-1 and GAGE expression were evaluated in 46 bone marrow multiple myeloma (MM) aspirates by RT-PCR. Expression of FOXP3/CTLA4 and RORyt, as markers for Tregs and Th17 cells, respectively, was investigated by quantitative PCR.RESULTS: MAGEC1/CT7 was expressed in 66% of MM samples. We did not find correlation between the presence of single CTA and expression of CTLA4 or RORyt neither expression of CD4(+) T-cell markers and the number of CTA simultaneously expressed in the tumor. However, we did observe a correlation between the percentage of plasma cells and the number of CTAs expressed in the patients' bone marrow.CONCLUSION: Although CTAs and immunomodulatory CD4(+) T cells represent potential targets for immunotherapy in MM, we did not find association among expression of such genes in MM.

AB - AIM: The present study aimed at correlating the expression of cancer/testis antigens (CTAs) with the expression of genes related to tumor-infiltrating T cells.MATERIALS & METHODS: MAGE-C1/CT-7, MAGEA3/6, NY-ESO-1, LAGE-1 and GAGE expression were evaluated in 46 bone marrow multiple myeloma (MM) aspirates by RT-PCR. Expression of FOXP3/CTLA4 and RORyt, as markers for Tregs and Th17 cells, respectively, was investigated by quantitative PCR.RESULTS: MAGEC1/CT7 was expressed in 66% of MM samples. We did not find correlation between the presence of single CTA and expression of CTLA4 or RORyt neither expression of CD4(+) T-cell markers and the number of CTA simultaneously expressed in the tumor. However, we did observe a correlation between the percentage of plasma cells and the number of CTAs expressed in the patients' bone marrow.CONCLUSION: Although CTAs and immunomodulatory CD4(+) T cells represent potential targets for immunotherapy in MM, we did not find association among expression of such genes in MM.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Antigens, Neoplasm

KW - Bone Marrow

KW - CD4-Positive T-Lymphocytes

KW - Female

KW - Gene Expression Regulation, Neoplastic

KW - Humans

KW - Male

KW - Middle Aged

KW - Multiple Myeloma

KW - Neoplasm Proteins

KW - Plasma Cells

KW - Tumor Markers, Biological

U2 - 10.2217/imt.14.24

DO - 10.2217/imt.14.24

M3 - SCORING: Journal article

C2 - 24896625

VL - 6

SP - 569

EP - 575

JO - IMMUNOTHERAPY-UK

JF - IMMUNOTHERAPY-UK

SN - 1750-743X

IS - 5

ER -