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Is the synchronization between pallidal and muscle activity in primary dystonia due to peripheral afferance or a motor drive?

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Is the synchronization between pallidal and muscle activity in primary dystonia due to peripheral afferance or a motor drive? / Sharott, Andrew; Grosse, Pascal; Kühn, Andrea A; Salih, Farid; Engel, Andreas K.; Kupsch, Andreas; Schneider, Gerd-Helge; Krauss, Joachim K; Brown, Peter.

in: BRAIN, Jahrgang 131, Nr. 2, 2, 2008, S. 473-484.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Sharott, A, Grosse, P, Kühn, AA, Salih, F, Engel, AK, Kupsch, A, Schneider, G-H, Krauss, JK & Brown, P 2008, 'Is the synchronization between pallidal and muscle activity in primary dystonia due to peripheral afferance or a motor drive?', BRAIN, Jg. 131, Nr. 2, 2, S. 473-484. <http://www.ncbi.nlm.nih.gov/pubmed/18178569?dopt=Citation>

APA

Sharott, A., Grosse, P., Kühn, A. A., Salih, F., Engel, A. K., Kupsch, A., Schneider, G-H., Krauss, J. K., & Brown, P. (2008). Is the synchronization between pallidal and muscle activity in primary dystonia due to peripheral afferance or a motor drive? BRAIN, 131(2), 473-484. [2]. http://www.ncbi.nlm.nih.gov/pubmed/18178569?dopt=Citation

Vancouver

Sharott A, Grosse P, Kühn AA, Salih F, Engel AK, Kupsch A et al. Is the synchronization between pallidal and muscle activity in primary dystonia due to peripheral afferance or a motor drive? BRAIN. 2008;131(2):473-484. 2.

Bibtex

@article{bf9875411c7e4afc8bd27b81b641c26a,
title = "Is the synchronization between pallidal and muscle activity in primary dystonia due to peripheral afferance or a motor drive?",
abstract = "The pathophysiological mechanisms of primary dystonia have largely remained obscure. Yet there is one undeniable observation: lesioning or high-frequency stimulation of the internal segment of the globus pallidus (GP) ameliorates dystonic symptoms. The latter observation implicates abnormal pallidal activity in the genesis of primary dystonia. Recently, excessive oscillatory pallidal activity in the 3-10 Hz frequency range, synchronized with dystonic EMG, has been related to the occurrence of involuntary muscle activity in these patients. However, it is unclear whether this pathological synchronization is driven by GP, caused by re-afference from dystonic muscle, or due to a combination of these two processes. Here we used the Directed Transfer Function as a spectral measure to identify the degree and direction of coupling across time between GP and muscle in seven patients with primary dystonia. We show that pallidal local field potential activity",
author = "Andrew Sharott and Pascal Grosse and K{\"u}hn, {Andrea A} and Farid Salih and Engel, {Andreas K.} and Andreas Kupsch and Gerd-Helge Schneider and Krauss, {Joachim K} and Peter Brown",
year = "2008",
language = "Deutsch",
volume = "131",
pages = "473--484",
journal = "BRAIN",
issn = "0006-8950",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Is the synchronization between pallidal and muscle activity in primary dystonia due to peripheral afferance or a motor drive?

AU - Sharott, Andrew

AU - Grosse, Pascal

AU - Kühn, Andrea A

AU - Salih, Farid

AU - Engel, Andreas K.

AU - Kupsch, Andreas

AU - Schneider, Gerd-Helge

AU - Krauss, Joachim K

AU - Brown, Peter

PY - 2008

Y1 - 2008

N2 - The pathophysiological mechanisms of primary dystonia have largely remained obscure. Yet there is one undeniable observation: lesioning or high-frequency stimulation of the internal segment of the globus pallidus (GP) ameliorates dystonic symptoms. The latter observation implicates abnormal pallidal activity in the genesis of primary dystonia. Recently, excessive oscillatory pallidal activity in the 3-10 Hz frequency range, synchronized with dystonic EMG, has been related to the occurrence of involuntary muscle activity in these patients. However, it is unclear whether this pathological synchronization is driven by GP, caused by re-afference from dystonic muscle, or due to a combination of these two processes. Here we used the Directed Transfer Function as a spectral measure to identify the degree and direction of coupling across time between GP and muscle in seven patients with primary dystonia. We show that pallidal local field potential activity

AB - The pathophysiological mechanisms of primary dystonia have largely remained obscure. Yet there is one undeniable observation: lesioning or high-frequency stimulation of the internal segment of the globus pallidus (GP) ameliorates dystonic symptoms. The latter observation implicates abnormal pallidal activity in the genesis of primary dystonia. Recently, excessive oscillatory pallidal activity in the 3-10 Hz frequency range, synchronized with dystonic EMG, has been related to the occurrence of involuntary muscle activity in these patients. However, it is unclear whether this pathological synchronization is driven by GP, caused by re-afference from dystonic muscle, or due to a combination of these two processes. Here we used the Directed Transfer Function as a spectral measure to identify the degree and direction of coupling across time between GP and muscle in seven patients with primary dystonia. We show that pallidal local field potential activity

M3 - SCORING: Zeitschriftenaufsatz

VL - 131

SP - 473

EP - 484

JO - BRAIN

JF - BRAIN

SN - 0006-8950

IS - 2

M1 - 2

ER -