Intravital Imaging of Thrombosis Models in Mice
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Intravital Imaging of Thrombosis Models in Mice. / Kiouptsi, Klytaimnistra; Casari, Martina; Mandel, Jonathan; Gao, Zhenling; Deppermann, Carsten.
in: HAMOSTASEOLOGIE, Jahrgang 43, Nr. 5, 10.2023, S. 348-359.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Intravital Imaging of Thrombosis Models in Mice
AU - Kiouptsi, Klytaimnistra
AU - Casari, Martina
AU - Mandel, Jonathan
AU - Gao, Zhenling
AU - Deppermann, Carsten
N1 - Thieme. All rights reserved.
PY - 2023/10
Y1 - 2023/10
N2 - Intravital microscopy is a powerful tool to study thrombosis in real time. The kinetics of thrombus formation and progression in vivo is studied after inflicting damage to the endothelium through mechanical, chemical, or laser injury. Mouse models of atherosclerosis are also used to induce thrombus formation. Vessels of different sizes and from different vascular beds such as carotid artery or vena cava, mesenteric or cremaster arterioles, can be targeted. Using fluorescent dyes, antibodies, or reporter mouse strains allows to visualize key cells and factors mediating the thrombotic processes. Here, we review the latest literature on using intravital microscopy to study thrombosis as well as thromboinflammation following transient middle cerebral artery occlusion, infection-induced immunothrombosis, and liver ischemia reperfusion.
AB - Intravital microscopy is a powerful tool to study thrombosis in real time. The kinetics of thrombus formation and progression in vivo is studied after inflicting damage to the endothelium through mechanical, chemical, or laser injury. Mouse models of atherosclerosis are also used to induce thrombus formation. Vessels of different sizes and from different vascular beds such as carotid artery or vena cava, mesenteric or cremaster arterioles, can be targeted. Using fluorescent dyes, antibodies, or reporter mouse strains allows to visualize key cells and factors mediating the thrombotic processes. Here, we review the latest literature on using intravital microscopy to study thrombosis as well as thromboinflammation following transient middle cerebral artery occlusion, infection-induced immunothrombosis, and liver ischemia reperfusion.
KW - Animals
KW - Mice
KW - Thrombosis
KW - Inflammation
KW - Disease Models, Animal
KW - Intravital Microscopy
KW - Endothelium
U2 - 10.1055/a-2118-2932
DO - 10.1055/a-2118-2932
M3 - SCORING: Review article
C2 - 37857297
VL - 43
SP - 348
EP - 359
JO - HAMOSTASEOLOGIE
JF - HAMOSTASEOLOGIE
SN - 0720-9355
IS - 5
ER -