Inter-site Variability of the Human Osteocyte Lacunar Network: Implications for Bone Quality
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Inter-site Variability of the Human Osteocyte Lacunar Network: Implications for Bone Quality. / Milovanovic, Petar; Busse, Björn.
in: CURR OSTEOPOROS REP, Jahrgang 17, Nr. 3, 06.2019, S. 105-115.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Inter-site Variability of the Human Osteocyte Lacunar Network: Implications for Bone Quality
AU - Milovanovic, Petar
AU - Busse, Björn
PY - 2019/6
Y1 - 2019/6
N2 - PURPOSE OF REVIEW: This article provides a review on the variability of the osteocyte lacunar network in the human skeleton. It highlights characteristics of the osteocyte lacunar network in relation to different skeletal sites and fracture susceptibility.RECENT FINDINGS: Application of 2D analyses (quantitative backscattered electron microscopy, histology, confocal laser scanning microscopy) and 3D reconstructions (microcomputed tomography and synchrotron radiation microcomputed tomography) provides extended high-resolution information on osteocyte lacunar properties in individuals of various age (fetal, children's growth, elderly), sex, and disease states with increased fracture risk. Recent findings on the distribution of osteocytes in the human skeleton are reviewed. Quantitative data highlighting the variability of the osteocyte lacunar network is presented with special emphasis on site specificity and maintenance of bone health. The causes and consequences of heterogeneous distribution of osteocyte lacunae both within specific regions of interest and on the skeletal level are reviewed and linked to differential bone quality factors and fracture susceptibility.
AB - PURPOSE OF REVIEW: This article provides a review on the variability of the osteocyte lacunar network in the human skeleton. It highlights characteristics of the osteocyte lacunar network in relation to different skeletal sites and fracture susceptibility.RECENT FINDINGS: Application of 2D analyses (quantitative backscattered electron microscopy, histology, confocal laser scanning microscopy) and 3D reconstructions (microcomputed tomography and synchrotron radiation microcomputed tomography) provides extended high-resolution information on osteocyte lacunar properties in individuals of various age (fetal, children's growth, elderly), sex, and disease states with increased fracture risk. Recent findings on the distribution of osteocytes in the human skeleton are reviewed. Quantitative data highlighting the variability of the osteocyte lacunar network is presented with special emphasis on site specificity and maintenance of bone health. The causes and consequences of heterogeneous distribution of osteocyte lacunae both within specific regions of interest and on the skeletal level are reviewed and linked to differential bone quality factors and fracture susceptibility.
U2 - 10.1007/s11914-019-00508-y
DO - 10.1007/s11914-019-00508-y
M3 - SCORING: Review article
C2 - 30980284
VL - 17
SP - 105
EP - 115
JO - CURR OSTEOPOROS REP
JF - CURR OSTEOPOROS REP
SN - 1544-1873
IS - 3
ER -