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Interleukin 1 and tumor necrosis factor stimulate cGMP formation in rat renal mesangial cells

Standard

Interleukin 1 and tumor necrosis factor stimulate cGMP formation in rat renal mesangial cells. / Pfeilschifter, J; Schwarzenbach, H.

in: FEBS LETT, Jahrgang 273, Nr. 1-2, 29.10.1990, S. 185-7.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Pfeilschifter, J & Schwarzenbach, H 1990, 'Interleukin 1 and tumor necrosis factor stimulate cGMP formation in rat renal mesangial cells', FEBS LETT, Jg. 273, Nr. 1-2, S. 185-7.

APA

Pfeilschifter, J., & Schwarzenbach, H. (1990). Interleukin 1 and tumor necrosis factor stimulate cGMP formation in rat renal mesangial cells. FEBS LETT, 273(1-2), 185-7.

Vancouver

Pfeilschifter J, Schwarzenbach H. Interleukin 1 and tumor necrosis factor stimulate cGMP formation in rat renal mesangial cells. FEBS LETT. 1990 Okt 29;273(1-2):185-7.

Bibtex

@article{345fac142c864751b6f9c80f220017e8,
title = "Interleukin 1 and tumor necrosis factor stimulate cGMP formation in rat renal mesangial cells",
abstract = "Treatment of mesangial cells with recombinant human interleukin 1 beta (IL-1 beta) or recombinant human tumor necrosis factor alpha (TNF alpha) dose-dependently increased cGMP formation. Both IL-1 beta and TNF alpha-stimulated formation of cGMP occurred after a initial lag period of 4 to 8 hours. Treatment of cells with actinomycin D, cycloheximide or dexamethason completely abolished cytokine-induced cGMP formation. Furthermore, the guanylate cyclase inhibitor Methylene blue completely blocked IL-1 beta- and TNF alpha-stimulated cGMP generation. NG-mono-methyl-L-arginine attenuated IL-1 beta- and TNF alpha-induced cGMP production, an effect that was reversed by L-arginine.",
keywords = "Animals, Cells, Cultured, Cyclic GMP, Glomerular Mesangium, Interleukin-1, Kinetics, Rats, Recombinant Proteins, Tumor Necrosis Factor-alpha",
author = "J Pfeilschifter and H Schwarzenbach",
year = "1990",
month = oct,
day = "29",
language = "English",
volume = "273",
pages = "185--7",
journal = "FEBS LETT",
issn = "0014-5793",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Interleukin 1 and tumor necrosis factor stimulate cGMP formation in rat renal mesangial cells

AU - Pfeilschifter, J

AU - Schwarzenbach, H

PY - 1990/10/29

Y1 - 1990/10/29

N2 - Treatment of mesangial cells with recombinant human interleukin 1 beta (IL-1 beta) or recombinant human tumor necrosis factor alpha (TNF alpha) dose-dependently increased cGMP formation. Both IL-1 beta and TNF alpha-stimulated formation of cGMP occurred after a initial lag period of 4 to 8 hours. Treatment of cells with actinomycin D, cycloheximide or dexamethason completely abolished cytokine-induced cGMP formation. Furthermore, the guanylate cyclase inhibitor Methylene blue completely blocked IL-1 beta- and TNF alpha-stimulated cGMP generation. NG-mono-methyl-L-arginine attenuated IL-1 beta- and TNF alpha-induced cGMP production, an effect that was reversed by L-arginine.

AB - Treatment of mesangial cells with recombinant human interleukin 1 beta (IL-1 beta) or recombinant human tumor necrosis factor alpha (TNF alpha) dose-dependently increased cGMP formation. Both IL-1 beta and TNF alpha-stimulated formation of cGMP occurred after a initial lag period of 4 to 8 hours. Treatment of cells with actinomycin D, cycloheximide or dexamethason completely abolished cytokine-induced cGMP formation. Furthermore, the guanylate cyclase inhibitor Methylene blue completely blocked IL-1 beta- and TNF alpha-stimulated cGMP generation. NG-mono-methyl-L-arginine attenuated IL-1 beta- and TNF alpha-induced cGMP production, an effect that was reversed by L-arginine.

KW - Animals

KW - Cells, Cultured

KW - Cyclic GMP

KW - Glomerular Mesangium

KW - Interleukin-1

KW - Kinetics

KW - Rats

KW - Recombinant Proteins

KW - Tumor Necrosis Factor-alpha

M3 - SCORING: Journal article

C2 - 2172027

VL - 273

SP - 185

EP - 187

JO - FEBS LETT

JF - FEBS LETT

SN - 0014-5793

IS - 1-2

ER -