Interdisciplinary Screening, Diagnosis, Therapy and Follow-up of Breast Cancer. Guideline of the DGGG and the DKG (S3-Level, AWMF Registry Number 032/045OL, December 2017) - Part 2 with Recommendations for the Therapy of Primary, Recurrent and Advanced Breast Cancer

TY - JOUR

T1 - Interdisciplinary Screening, Diagnosis, Therapy and Follow-up of Breast Cancer. Guideline of the DGGG and the DKG (S3-Level, AWMF Registry Number 032/045OL, December 2017) - Part 2 with Recommendations for the Therapy of Primary, Recurrent and Advanced Breast Cancer

AU - Wöckel, Achim

AU - Festl, Jasmin

AU - Stüber, Tanja

AU - Brust, Katharina

AU - Krockenberger, Mathias

AU - Heuschmann, Peter U

AU - Jírů-Hillmann, Steffi

AU - Albert, Ute-Susann

AU - Budach, Wilfried

AU - Follmann, Markus

AU - Janni, Wolfgang

AU - Kopp, Ina

AU - Kreienberg, Rolf

AU - Kühn, Thorsten

AU - Langer, Thomas

AU - Nothacker, Monika

AU - Scharl, Anton

AU - Schreer, Ingrid

AU - Link, Hartmut

AU - Engel, Jutta

AU - Fehm, Tanja

AU - Weis, Joachim

AU - Welt, Anja

AU - Steckelberg, Anke

AU - Feyer, Petra

AU - König, Klaus

AU - Hahne, Andrea

AU - Baumgartner, Traudl

AU - Kreipe, Hans H

AU - Knoefel, Wolfram Trudo

AU - Denkinger, Michael

AU - Brucker, Sara

AU - Lüftner, Diana

AU - Kubisch, Christian

AU - Gerlach, Christina

AU - Lebeau, Annette

AU - Siedentopf, Friederike

AU - Petersen, Cordula

AU - Bartsch, Hans Helge

AU - Schulz-Wendtland, Rüdiger

AU - Hahn, Markus

AU - Hanf, Volker

AU - Müller-Schimpfle, Markus

AU - Henscher, Ulla

AU - Roncarati, Renza

AU - Katalinic, Alexander

AU - Heitmann, Christoph

AU - Honegger, Christoph

AU - Paradies, Kerstin

AU - Bjelic-Radisic, Vesna

AU - Degenhardt, Friedrich

AU - Wenz, Frederik

AU - Rick, Oliver

AU - Hölzel, Dieter

AU - Zaiss, Matthias

AU - Kemper, Gudrun

AU - Budach, Volker

AU - Denkert, Carsten

AU - Gerber, Bernd

AU - Tesch, Hans

AU - Hirsmüller, Susanne

AU - Sinn, Hans-Peter

AU - Dunst, Jürgen

AU - Münstedt, Karsten

AU - Bick, Ulrich

AU - Fallenberg, Eva

AU - Tholen, Reina

AU - Hung, Roswita

AU - Baumann, Freerk

AU - Beckmann, Matthias W

AU - Blohmer, Jens

AU - Fasching, Peter

AU - Lux, Michael P

AU - Harbeck, Nadia

AU - Hadji, Peyman

AU - Hauner, Hans

AU - Heywang-Köbrunner, Sylvia

AU - Huober, Jens

AU - Hübner, Jutta

AU - Jackisch, Christian

AU - Loibl, Sibylle

AU - Lück, Hans-Jürgen

AU - von Minckwitz, Gunter

AU - Möbus, Volker

AU - Müller, Volkmar

AU - Nöthlings, Ute

AU - Schmidt, Marcus

AU - Schmutzler, Rita

AU - Schneeweiss, Andreas

AU - Schütz, Florian

AU - Stickeler, Elmar

AU - Thomssen, Christoph

AU - Untch, Michael

AU - Wesselmann, Simone

AU - Bücker, Arno

AU - Buck, Andreas

AU - Stangl, Stephanie

N1 - Leitlinie

PY - 2018/11

Y1 - 2018/11

N2 - Purpose The aim of this official guideline coordinated and published by the German Society for Gynecology and Obstetrics (DGGG) and the German Cancer Society (DKG) was to optimize the screening, diagnosis, therapy and follow-up care of breast cancer. Method The process of updating the S3 guideline published in 2012 was based on the adaptation of identified source guidelines. They were combined with reviews of evidence compiled using PICO (Patients/Interventions/Control/Outcome) questions and with the results of a systematic search of literature databases followed by the selection and evaluation of the identified literature. The interdisciplinary working groups took the identified materials as their starting point and used them to develop suggestions for recommendations and statements, which were then modified and graded in a structured consensus process procedure. Recommendations Part 2 of this short version of the guideline presents recommendations for the therapy of primary, recurrent and metastatic breast cancer. Loco-regional therapies are de-escalated in the current guideline. In addition to reducing the safety margins for surgical procedures, the guideline also recommends reducing the radicality of axillary surgery. The choice and extent of systemic therapy depends on the respective tumor biology. New substances are becoming available, particularly to treat metastatic breast cancer.

AB - Purpose The aim of this official guideline coordinated and published by the German Society for Gynecology and Obstetrics (DGGG) and the German Cancer Society (DKG) was to optimize the screening, diagnosis, therapy and follow-up care of breast cancer. Method The process of updating the S3 guideline published in 2012 was based on the adaptation of identified source guidelines. They were combined with reviews of evidence compiled using PICO (Patients/Interventions/Control/Outcome) questions and with the results of a systematic search of literature databases followed by the selection and evaluation of the identified literature. The interdisciplinary working groups took the identified materials as their starting point and used them to develop suggestions for recommendations and statements, which were then modified and graded in a structured consensus process procedure. Recommendations Part 2 of this short version of the guideline presents recommendations for the therapy of primary, recurrent and metastatic breast cancer. Loco-regional therapies are de-escalated in the current guideline. In addition to reducing the safety margins for surgical procedures, the guideline also recommends reducing the radicality of axillary surgery. The choice and extent of systemic therapy depends on the respective tumor biology. New substances are becoming available, particularly to treat metastatic breast cancer.

KW - Journal Article

U2 - 10.1055/a-0646-4630

DO - 10.1055/a-0646-4630

M3 - Other (editorial matter etc.)

C2 - 30581198

VL - 78

SP - 1056

EP - 1088

JO - GEBURTSH FRAUENHEILK

JF - GEBURTSH FRAUENHEILK

SN - 0016-5751

IS - 11

ER -