Insights into human kidney function from the study of Drosophila

Sybille Koehler; Tobias B Huber

doi:10.1007/s00467-023-05996-w

Insights into human kidney function from the study of Drosophila

Standard

Insights into human kidney function from the study of Drosophila. / Koehler, Sybille ; Huber, Tobias B.

in: PEDIATR NEPHROL, Jahrgang 38, Nr. 12, 12.2023, S. 3875-3887.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Koehler, S & Huber, TB 2023, 'Insights into human kidney function from the study of Drosophila', PEDIATR NEPHROL, Jg. 38, Nr. 12, S. 3875-3887. https://doi.org/10.1007/s00467-023-05996-w

APA

Koehler, S., & Huber, T. B. (2023). Insights into human kidney function from the study of Drosophila. PEDIATR NEPHROL, 38(12), 3875-3887. https://doi.org/10.1007/s00467-023-05996-w

Vancouver

Koehler S , Huber TB. Insights into human kidney function from the study of Drosophila. PEDIATR NEPHROL. 2023 Dez;38(12):3875-3887. https://doi.org/10.1007/s00467-023-05996-w

Bibtex

@article{95a0fc1a2ad94e50a8997e16e369a6d0,

title = "Insights into human kidney function from the study of Drosophila",

abstract = "Biological and biomedical research using Drosophila melanogaster as a model organism has gained recognition through several Nobel prizes within the last 100 years. Drosophila exhibits several advantages when compared to other in vivo models such as mice and rats, as its life cycle is very short, animal maintenance is easy and inexpensive and a huge variety of transgenic strains and tools are publicly available. Moreover, more than 70% of human disease-causing genes are highly conserved in the fruit fly. Here, we explain the use of Drosophila in nephrology research and describe two kidney tissues, Malpighian tubules and the nephrocytes. The latter are the homologous cells to mammalian glomerular podocytes and helped to provide insights into a variety of signaling pathways due to the high morphological similarities and the conserved molecular make-up between nephrocytes and podocytes. In recent years, nephrocytes have also been used to study inter-organ communication as links between nephrocytes and the heart, the immune system and the muscles have been described. In addition, other tissues such as the eye and the reproductive system can be used to study the functional role of proteins being part of the kidney filtration barrier.",

keywords = "Humans, Animals, Rats, Mice, Drosophila/metabolism, Drosophila melanogaster/genetics, Drosophila Proteins/genetics, Kidney/metabolism, Animals, Genetically Modified, Podocytes/metabolism, Mammals/metabolism",

author = "Sybille Koehler and Huber, {Tobias B}",

note = "{\textcopyright} 2023. The Author(s).",

year = "2023",

month = dec,

doi = "10.1007/s00467-023-05996-w",

language = "English",

volume = "38",

pages = "3875--3887",

journal = "PEDIATR NEPHROL",

issn = "0931-041X",

publisher = "Springer",

number = "12",

}

RIS

TY - JOUR

T1 - Insights into human kidney function from the study of Drosophila

AU - Koehler, Sybille

AU - Huber, Tobias B

PY - 2023/12

Y1 - 2023/12

N2 - Biological and biomedical research using Drosophila melanogaster as a model organism has gained recognition through several Nobel prizes within the last 100 years. Drosophila exhibits several advantages when compared to other in vivo models such as mice and rats, as its life cycle is very short, animal maintenance is easy and inexpensive and a huge variety of transgenic strains and tools are publicly available. Moreover, more than 70% of human disease-causing genes are highly conserved in the fruit fly. Here, we explain the use of Drosophila in nephrology research and describe two kidney tissues, Malpighian tubules and the nephrocytes. The latter are the homologous cells to mammalian glomerular podocytes and helped to provide insights into a variety of signaling pathways due to the high morphological similarities and the conserved molecular make-up between nephrocytes and podocytes. In recent years, nephrocytes have also been used to study inter-organ communication as links between nephrocytes and the heart, the immune system and the muscles have been described. In addition, other tissues such as the eye and the reproductive system can be used to study the functional role of proteins being part of the kidney filtration barrier.

AB - Biological and biomedical research using Drosophila melanogaster as a model organism has gained recognition through several Nobel prizes within the last 100 years. Drosophila exhibits several advantages when compared to other in vivo models such as mice and rats, as its life cycle is very short, animal maintenance is easy and inexpensive and a huge variety of transgenic strains and tools are publicly available. Moreover, more than 70% of human disease-causing genes are highly conserved in the fruit fly. Here, we explain the use of Drosophila in nephrology research and describe two kidney tissues, Malpighian tubules and the nephrocytes. The latter are the homologous cells to mammalian glomerular podocytes and helped to provide insights into a variety of signaling pathways due to the high morphological similarities and the conserved molecular make-up between nephrocytes and podocytes. In recent years, nephrocytes have also been used to study inter-organ communication as links between nephrocytes and the heart, the immune system and the muscles have been described. In addition, other tissues such as the eye and the reproductive system can be used to study the functional role of proteins being part of the kidney filtration barrier.

KW - Humans

KW - Animals

KW - Rats

KW - Mice

KW - Drosophila/metabolism

KW - Drosophila melanogaster/genetics

KW - Drosophila Proteins/genetics

KW - Kidney/metabolism

KW - Animals, Genetically Modified

KW - Podocytes/metabolism

KW - Mammals/metabolism

U2 - 10.1007/s00467-023-05996-w

DO - 10.1007/s00467-023-05996-w

M3 - SCORING: Review article

C2 - 37171583

VL - 38

SP - 3875

EP - 3887

JO - PEDIATR NEPHROL

JF - PEDIATR NEPHROL

SN - 0931-041X

IS - 12

ER -