Initial results after implementation of a multimodal treatment for peritoneal malignancies
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Initial results after implementation of a multimodal treatment for peritoneal malignancies. / Raue, W; Tsilimparis, N; Langelotz, C; Rau, B; Schwenk, W; Hartmann, J.
in: ACTA CHIR BELG, Jahrgang 111, Nr. 2, 31.05.2011, S. 68-72.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Initial results after implementation of a multimodal treatment for peritoneal malignancies
AU - Raue, W
AU - Tsilimparis, N
AU - Langelotz, C
AU - Rau, B
AU - Schwenk, W
AU - Hartmann, J
PY - 2011/5/31
Y1 - 2011/5/31
N2 - INTRODUCTION: Peritoneal carcinomatosis represents a clinical condition with a limited perspective concerning long term survival. The combination of surgical cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC) represents a complex multimodal therapeutic management concept with promising results for prolongation of survival. For the identification of pitfalls during implementation of the HIPEC procedure into clinical practice an observational study was conducted.METHODS: Between 2005 and 2009 data from all patients treated with cytoreductive surgery and HIPEC for peritoneal carcinomatosis was prospectively collected and analysed.RESULTS: During the observational interval a total of 42 patients underwent surgical treatment for peritoneal carcinomatosis. In 34 patients the complete procedure with surgical cytoreduction and HIPEC was performed. Perioperative mortality (6%) and morbidity (35%) was similar to other reported series. Twenty-five patients (76%) survived the 18 months follow-up period after complete procedure.CONCLUSION: The multimodal therapeutic treatment concept of surgical cytoreduction and following HIPEC leads to promising results for patients suffering from peritoneal carcinomatosis. However this treatment concept is afflicted with a relevant risk of postoperative complications.
AB - INTRODUCTION: Peritoneal carcinomatosis represents a clinical condition with a limited perspective concerning long term survival. The combination of surgical cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC) represents a complex multimodal therapeutic management concept with promising results for prolongation of survival. For the identification of pitfalls during implementation of the HIPEC procedure into clinical practice an observational study was conducted.METHODS: Between 2005 and 2009 data from all patients treated with cytoreductive surgery and HIPEC for peritoneal carcinomatosis was prospectively collected and analysed.RESULTS: During the observational interval a total of 42 patients underwent surgical treatment for peritoneal carcinomatosis. In 34 patients the complete procedure with surgical cytoreduction and HIPEC was performed. Perioperative mortality (6%) and morbidity (35%) was similar to other reported series. Twenty-five patients (76%) survived the 18 months follow-up period after complete procedure.CONCLUSION: The multimodal therapeutic treatment concept of surgical cytoreduction and following HIPEC leads to promising results for patients suffering from peritoneal carcinomatosis. However this treatment concept is afflicted with a relevant risk of postoperative complications.
KW - Adult
KW - Aged
KW - Anastomosis, Surgical
KW - Antineoplastic Combined Chemotherapy Protocols/administration & dosage
KW - Combined Modality Therapy
KW - Female
KW - Humans
KW - Hyperthermia, Induced
KW - Injections, Intraperitoneal
KW - Male
KW - Middle Aged
KW - Ovarian Neoplasms/pathology
KW - Peritoneal Neoplasms/mortality
KW - Peritoneum/surgery
KW - Postoperative Complications/epidemiology
KW - Pseudomyxoma Peritonei/therapy
U2 - 10.1080/00015458.2011.11680709
DO - 10.1080/00015458.2011.11680709
M3 - SCORING: Journal article
C2 - 21618850
VL - 111
SP - 68
EP - 72
JO - ACTA CHIR BELG
JF - ACTA CHIR BELG
SN - 0001-5458
IS - 2
ER -